PMID- 28371657 OWN - NLM STAT- MEDLINE DCOM- 20171213 LR - 20240319 IS - 1872-7506 (Electronic) IS - 0165-1781 (Print) IS - 0925-4927 (Linking) VI - 263 DP - 2017 May 30 TI - Brain-derived neurotrophic factor Val66Met genotype modulates amygdala habituation. PG - 85-92 LID - S0925-4927(16)30226-8 [pii] LID - 10.1016/j.pscychresns.2017.03.008 [doi] AB - A deficit in amygdala habituation to repeated emotional stimuli may be an endophenotype of disorders characterized by emotion dysregulation, such as borderline personality disorder (BPD). Amygdala reactivity to emotional stimuli is genetically modulated by brain-derived neurotrophic factor (BDNF) variants. Whether amygdala habituation itself is also modulated by BDNF genotypes remains unknown. We used imaging-genetics to examine the effect of BDNF Val66Met genotypes on amygdala habituation to repeated emotional stimuli. We used functional magnetic resonance imaging (fMRI) in 57 subjects (19 BPD patients, 18 patients with schizotypal personality disorder [SPD] and 20 healthy controls [HC]) during a task involving viewing of unpleasant, neutral, and pleasant pictures, each presented twice to measure habituation. Amygdala responses across genotypes (Val66Met SNP Met allele-carriers vs. Non-Met carriers) and diagnoses (HC, BPD, SPD) were examined with ANOVA. The BDNF 66Met allele was significantly associated with a deficit in amygdala habituation, particularly for emotional pictures. The association of the 66Met allele with a deficit in habituation to unpleasant emotional pictures remained significant in the subsample of BPD patients. Using imaging-genetics, we found preliminary evidence that deficient amygdala habituation may be modulated by BDNF genotype. CI - Copyright (c) 2017. Published by Elsevier B.V. FAU - Perez-Rodriguez, M Mercedes AU - Perez-Rodriguez MM AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Mental Illness Research Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA; CIBERSAM, Autonoma University, Fundacion Jimenez Diaz and Ramon y Cajal Hospital, Madrid, Spain. Electronic address: mercedes.perez@mssm.edu. FAU - New, Antonia S AU - New AS AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Mental Illness Research Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA. FAU - Goldstein, Kim E AU - Goldstein KE AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - Rosell, Daniel AU - Rosell D AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Mental Illness Research Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA. FAU - Yuan, Qiaoping AU - Yuan Q AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9412, USA. FAU - Zhou, Zhifeng AU - Zhou Z AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9412, USA. FAU - Hodgkinson, Colin AU - Hodgkinson C AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9412, USA. FAU - Goldman, David AU - Goldman D AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9412, USA. FAU - Siever, Larry J AU - Siever LJ AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Mental Illness Research Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA. FAU - Hazlett, Erin A AU - Hazlett EA AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Mental Illness Research Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA. LA - eng GR - KL2 TR001435/TR/NCATS NIH HHS/United States GR - R01 MH073911/MH/NIMH NIH HHS/United States GR - UL1 RR029887/RR/NCRR NIH HHS/United States PT - Journal Article DEP - 20170324 PL - Netherlands TA - Psychiatry Res Neuroimaging JT - Psychiatry research. Neuroimaging JID - 101723001 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) RN - AE28F7PNPL (Methionine) RN - HG18B9YRS7 (Valine) SB - IM MH - Adult MH - Alleles MH - Amygdala/*diagnostic imaging MH - Brain-Derived Neurotrophic Factor/*genetics MH - Emotions/physiology MH - Female MH - *Genotype MH - Habituation, Psychophysiologic/*genetics MH - Humans MH - Magnetic Resonance Imaging/methods MH - Male MH - Methionine/*genetics MH - Middle Aged MH - Photic Stimulation/methods MH - Schizotypal Personality Disorder/diagnostic imaging/genetics/psychology MH - Valine/*genetics PMC - PMC5856456 MID - NIHMS949115 OTO - NOTNLM OT - Amygdala OT - BDNF OT - Borderline personality disorder OT - Emotion regulation OT - Extinction OT - Habituation COIS- Declarations of interest The authors report no biomedical financial interests or other potential conflicts of interest. EDAT- 2017/04/04 06:00 MHDA- 2017/12/14 06:00 PMCR- 2018/05/30 CRDT- 2017/04/04 06:00 PHST- 2016/08/08 00:00 [received] PHST- 2017/02/04 00:00 [revised] PHST- 2017/03/20 00:00 [accepted] PHST- 2017/04/04 06:00 [pubmed] PHST- 2017/12/14 06:00 [medline] PHST- 2017/04/04 06:00 [entrez] PHST- 2018/05/30 00:00 [pmc-release] AID - S0925-4927(16)30226-8 [pii] AID - 10.1016/j.pscychresns.2017.03.008 [doi] PST - ppublish SO - Psychiatry Res Neuroimaging. 2017 May 30;263:85-92. doi: 10.1016/j.pscychresns.2017.03.008. Epub 2017 Mar 24.