PMID- 28372280
OWN - NLM
STAT- MEDLINE
DCOM- 20170717
LR  - 20181202
IS  - 1878-3619 (Electronic)
IS  - 0959-2989 (Linking)
VI  - 28
IP  - s1
DP  - 2017
TI  - Evaluation of the pro-angiogenic effect of nanoscale extracellular vesicles 
      derived from human umbilical cord mesenchymal stem cells.
PG  - S75-S79
LID - 10.3233/BME-171626 [doi]
AB  - Mesenchymal stem cells (MSCs) are a common tool in regenerative medicine. The 
      nanoscale extracellular vesicles (nEVs) secreted by these cells were recently 
      brought up to light thanks to their therapeutic potential. In this study, we 
      assessed the in vitro behaviour of human umbilical vein endothelial cells 
      (HUVECs) exposed to nEVs derived from human umbilical cord mesenchymal stem cells 
      (hUC-MSCs). Nanoscale extracellular vesicles were isolated and characterized by 
      NanoSight(R) and flow cytometry. HUVECs were stimulated with various concentrations 
      of nEVs. To assess nEV interactions with HUVECs, confocal microscopy and 
      angiogenesis assay were performed. The use of nEVs derived from hUC-MSCs was able 
      to produce positive outcomes on HUVECs by acting on their angiogenic potential.
FAU - Dostert, G
AU  - Dostert G
AD  - UMR 7365 CNRS-Universite de Lorraine IMoPA, Vandoeuvre-les-Nancy, France.
FAU - Willemin, A-S
AU  - Willemin AS
AD  - UMR 7365 CNRS-Universite de Lorraine IMoPA, Vandoeuvre-les-Nancy, France.
FAU - Jouan-Hureaux, V
AU  - Jouan-Hureaux V
AD  - UMR 7039 CNRS-Universite de Lorraine CRAN, Vandoeuvre-les-Nancy, France.
FAU - Louis, H
AU  - Louis H
AD  - FR BMCT 3209, CNRS-INSERM-UL-CHRU de Nancy, Vandoeuvre-les-Nancy, France.
AD  - INSERM U1116, Vandoeuvre-les-Nancy, France.
FAU - Hupont, S
AU  - Hupont S
AD  - FR BMCT 3209, CNRS-INSERM-UL-CHRU de Nancy, Vandoeuvre-les-Nancy, France.
FAU - Gillet, P
AU  - Gillet P
AD  - UMR 7365 CNRS-Universite de Lorraine IMoPA, Vandoeuvre-les-Nancy, France.
AD  - CHRU de Nancy, Vandoeuvre-les-Nancy, France.
FAU - Menu, P
AU  - Menu P
AD  - UMR 7365 CNRS-Universite de Lorraine IMoPA, Vandoeuvre-les-Nancy, France.
AD  - Faculte de Pharmacie, Nancy, France.
FAU - Decot, V
AU  - Decot V
AD  - UMR 7365 CNRS-Universite de Lorraine IMoPA, Vandoeuvre-les-Nancy, France.
AD  - CHRU de Nancy, Vandoeuvre-les-Nancy, France.
FAU - Moby, V
AU  - Moby V
AD  - UMR 7365 CNRS-Universite de Lorraine IMoPA, Vandoeuvre-les-Nancy, France.
AD  - CHRU de Nancy, Vandoeuvre-les-Nancy, France.
FAU - Velot, E
AU  - Velot E
AD  - UMR 7365 CNRS-Universite de Lorraine IMoPA, Vandoeuvre-les-Nancy, France.
AD  - Faculte de Pharmacie, Nancy, France.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Biomed Mater Eng
JT  - Bio-medical materials and engineering
JID - 9104021
RN  - 0 (Angiogenesis Inducing Agents)
SB  - IM
MH  - Angiogenesis Inducing Agents/*metabolism
MH  - Cell Culture Techniques
MH  - Cells, Cultured
MH  - Extracellular Vesicles/*metabolism/ultrastructure
MH  - Human Umbilical Vein Endothelial Cells
MH  - Humans
MH  - Mesenchymal Stem Cells/*cytology/metabolism
MH  - *Neovascularization, Physiologic
MH  - Particle Size
MH  - Umbilical Cord/*cytology
OTO - NOTNLM
OT  - HUVECs
OT  - Nanoscale extracellular vesicles
OT  - angiogenesis
OT  - human umbilical cord MSCs
EDAT- 2017/04/05 06:00
MHDA- 2017/07/18 06:00
CRDT- 2017/04/05 06:00
PHST- 2017/04/05 06:00 [entrez]
PHST- 2017/04/05 06:00 [pubmed]
PHST- 2017/07/18 06:00 [medline]
AID - BME1626 [pii]
AID - 10.3233/BME-171626 [doi]
PST - ppublish
SO  - Biomed Mater Eng. 2017;28(s1):S75-S79. doi: 10.3233/BME-171626.