PMID- 28373090
OWN - NLM
STAT- MEDLINE
DCOM- 20180319
LR  - 20180905
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 650
DP  - 2017 May 22
TI  - Interleukin-18 and its receptor are expressed in gonadotropin-releasing hormone 
      neurons of mouse and rat forebrain.
PG  - 33-37
LID - S0304-3940(17)30281-1 [pii]
LID - 10.1016/j.neulet.2017.03.051 [doi]
AB  - Interleukin-18 (IL-18) is a pro-inflammatory cytokine and an important mediator 
      of peripheral inflammation and host immune response. IL-18 functions through its 
      binding with the IL-18 receptor (IL-18R), which consists of two chains, an 
      IL-18-binding alpha chain (IL-18Ralpha) and a signaling beta chain. IL-18 and IL-18R are 
      expressed in the brain; however, limited information is available on IL-18R 
      expression and the role of IL-18 in neurosecretory cells. In the present study, 
      we used immunohistochemical techniques to investigate the distribution of IL-18Ralpha 
      and IL-18 in the hypothalamus of male mice and rats. IL-18Ralpha-positive and 
      IL-18-positive perikarya and fibers were found scattered throughout the medial 
      septal nucleus, the nuclei of the vertical and horizontal limbs of the diagonal 
      band, the organum vasculosum of the laminae terminalis, the preoptic area, and 
      the anterior hypothalamic area. It is well known that gonadotropin-releasing 
      hormone (GnRH) neuronal somata and/or fibers are found in these regions. 
      Therefore, we performed double-label immunofluorescence for IL-18Ralpha/IL-18 and 
      GnRH. IL-18Ralpha was expressed in approximately 60% of GnRH-immunopositive 
      perikarya, and IL-18 was distributed in all GnRH-immunopositive perikarya. These 
      observations suggest that IL-18 exerts direct effects upon the GnRH neuron via 
      IL-18Ralpha and acts on GnRH neurons through an autocrine or paracrine pathway.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Kuwahara-Otani, Sachi
AU  - Kuwahara-Otani S
AD  - Department of Anatomy and Cell Biology, Hyogo College of Medicine, Hyogo 
      663-8501, Japan. Electronic address: sachik@hyo-med.ac.jp.
FAU - Maeda, Seishi
AU  - Maeda S
AD  - Department of Anatomy and Cell Biology, Hyogo College of Medicine, Hyogo 
      663-8501, Japan.
FAU - Kobayashi, Kimiko
AU  - Kobayashi K
AD  - Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 
      663-8501, Japan.
FAU - Minato, Yusuke
AU  - Minato Y
AD  - Department of Anatomy and Cell Biology, Hyogo College of Medicine, Hyogo 
      663-8501, Japan.
FAU - Tanaka, Koichi
AU  - Tanaka K
AD  - Department of Anatomy and Cell Biology, Hyogo College of Medicine, Hyogo 
      663-8501, Japan.
FAU - Yamanishi, Kyosuke
AU  - Yamanishi K
AD  - Department of Neuropsychiatry, Hyogo College of Medicine, Hyogo 663-8501, Japan.
FAU - Hata, Masaki
AU  - Hata M
AD  - Laboratory of Tumor Immunology and Cell Therapy, Hyogo College of Medicine, Hyogo 
      663-8501, Japan.
FAU - Li, Wen
AU  - Li W
AD  - Laboratory of Tumor Immunology and Cell Therapy, Hyogo College of Medicine, Hyogo 
      663-8501, Japan.
FAU - Hayakawa, Tetsu
AU  - Hayakawa T
AD  - Laboratory of Tumor Immunology and Cell Therapy, Hyogo College of Medicine, Hyogo 
      663-8501, Japan.
FAU - Noguchi, Koichi
AU  - Noguchi K
AD  - Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 
      663-8501, Japan.
FAU - Okamura, Haruki
AU  - Okamura H
AD  - Laboratory of Tumor Immunology and Cell Therapy, Hyogo College of Medicine, Hyogo 
      663-8501, Japan.
FAU - Yagi, Hideshi
AU  - Yagi H
AD  - Department of Anatomy and Cell Biology, Hyogo College of Medicine, Hyogo 
      663-8501, Japan. Electronic address: h-yagi@hyo-med.ac.jp.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170401
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Interleukin-18)
RN  - 0 (Receptors, Interleukin-18)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation/physiology
MH  - Gonadotropin-Releasing Hormone/*metabolism
MH  - Hypothalamus/*metabolism
MH  - Interleukin-18/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neurons/cytology/*metabolism
MH  - Organ Specificity/physiology
MH  - Prosencephalon/cytology/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Interleukin-18/*metabolism
MH  - Species Specificity
MH  - Tissue Distribution
OTO - NOTNLM
OT  - GnRH neuron
OT  - Hypothalamus
OT  - IL-18
OT  - IL-18Ralpha
EDAT- 2017/04/05 06:00
MHDA- 2018/03/20 06:00
CRDT- 2017/04/05 06:00
PHST- 2017/01/30 00:00 [received]
PHST- 2017/03/20 00:00 [revised]
PHST- 2017/03/31 00:00 [accepted]
PHST- 2017/04/05 06:00 [pubmed]
PHST- 2018/03/20 06:00 [medline]
PHST- 2017/04/05 06:00 [entrez]
AID - S0304-3940(17)30281-1 [pii]
AID - 10.1016/j.neulet.2017.03.051 [doi]
PST - ppublish
SO  - Neurosci Lett. 2017 May 22;650:33-37. doi: 10.1016/j.neulet.2017.03.051. Epub 
      2017 Apr 1.