PMID- 28373773
OWN - NLM
STAT- MEDLINE
DCOM- 20170914
LR  - 20181113
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 23
IP  - 11
DP  - 2017 Mar 21
TI  - Factors associated with residual gastroesophageal reflux disease symptoms in 
      patients receiving proton pump inhibitor maintenance therapy.
PG  - 2060-2067
LID - 10.3748/wjg.v23.i11.2060 [doi]
AB  - AIM: To elucidate the factors associated with residual gastroesophageal reflux 
      disease (GERD) symptoms in patients receiving proton pump inhibitor (PPI) 
      maintenance therapy in clinical practice. METHODS: The study included 39 GERD 
      patients receiving maintenance PPI therapy. Residual symptoms were assessed using 
      the Frequency Scale for Symptoms of GERD (FSSG) questionnaire and the 
      Gastrointestinal Symptom Rating Scale (GSRS). The relationships between the FSSG 
      score and patient background factors, including the CYP2C19 genotype, were 
      analyzed. RESULTS: The FSSG scores ranged from 1 to 28 points (median score: 7.5 
      points), and 19 patients (48.7%) had a score of 8 points or more. The patients' 
      GSRS scores were significantly correlated with their FSSG scores (correlation 
      coefficient = 0.47, P < 0.005). In erosive esophagitis patients, the FSSG scores 
      of the CYP2C19 rapid metabolizers (RMs) were significantly higher than the scores 
      of the poor metabolizers and intermediate metabolizers (total scores: 16.7 +/- 8.6 
      vs 7.8 +/- 5.4, P < 0.05; acid reflux-related symptom scores: 12 +/- 1.9 vs 2.5 +/- 
      0.8, P < 0.005). In contrast, the FSSG scores of the CYP2C19 RMs in the 
      non-erosive reflux disease patients were significantly lower than those of the 
      other patients (total scores: 5.5 +/- 1.0 vs 11.8 +/- 6.3, P < 0.05; dysmotility 
      symptom-related scores: 1.0 +/- 0.4 vs 6.0 +/- 0.8, P < 0.01). CONCLUSION: 
      Approximately half of the GERD patients receiving maintenance PPI therapy had 
      residual symptoms associated with a lower quality of life, and the CYP2C19 
      genotype appeared to be associated with these residual symptoms.
FAU - Kawara, Fumiaki
AU  - Kawara F
AD  - Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsuhiro Masuda, Masaya Saito, 
      Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, 
      Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, 
      Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
FAU - Fujita, Tsuyoshi
AU  - Fujita T
AD  - Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsuhiro Masuda, Masaya Saito, 
      Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, 
      Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, 
      Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
FAU - Morita, Yoshinori
AU  - Morita Y
AD  - Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsuhiro Masuda, Masaya Saito, 
      Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, 
      Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, 
      Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
FAU - Uda, Atsushi
AU  - Uda A
AD  - Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsuhiro Masuda, Masaya Saito, 
      Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, 
      Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, 
      Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
FAU - Masuda, Atsuhiro
AU  - Masuda A
AD  - Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsuhiro Masuda, Masaya Saito, 
      Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, 
      Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, 
      Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
FAU - Saito, Masaya
AU  - Saito M
AD  - Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsuhiro Masuda, Masaya Saito, 
      Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, 
      Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, 
      Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
FAU - Ooi, Makoto
AU  - Ooi M
AD  - Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsuhiro Masuda, Masaya Saito, 
      Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, 
      Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, 
      Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
FAU - Ishida, Tsukasa
AU  - Ishida T
AD  - Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsuhiro Masuda, Masaya Saito, 
      Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, 
      Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, 
      Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
FAU - Kondo, Yasuyuki
AU  - Kondo Y
AD  - Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsuhiro Masuda, Masaya Saito, 
      Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, 
      Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, 
      Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
FAU - Yoshida, Shiei
AU  - Yoshida S
AD  - Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsuhiro Masuda, Masaya Saito, 
      Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, 
      Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, 
      Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
FAU - Okuno, Tatsuya
AU  - Okuno T
AD  - Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsuhiro Masuda, Masaya Saito, 
      Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, 
      Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, 
      Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
FAU - Yano, Yoshihiko
AU  - Yano Y
AD  - Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsuhiro Masuda, Masaya Saito, 
      Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, 
      Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, 
      Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
FAU - Yoshida, Masaru
AU  - Yoshida M
AD  - Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsuhiro Masuda, Masaya Saito, 
      Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, 
      Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, 
      Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
FAU - Kutsumi, Hiromu
AU  - Kutsumi H
AD  - Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsuhiro Masuda, Masaya Saito, 
      Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, 
      Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, 
      Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
FAU - Hayakumo, Takanobu
AU  - Hayakumo T
AD  - Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsuhiro Masuda, Masaya Saito, 
      Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, 
      Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, 
      Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
FAU - Yamashita, Kazuhiko
AU  - Yamashita K
AD  - Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsuhiro Masuda, Masaya Saito, 
      Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, 
      Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, 
      Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
FAU - Hirano, Takeshi
AU  - Hirano T
AD  - Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsuhiro Masuda, Masaya Saito, 
      Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, 
      Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, 
      Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
FAU - Hirai, Midori
AU  - Hirai M
AD  - Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsuhiro Masuda, Masaya Saito, 
      Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, 
      Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, 
      Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
FAU - Azuma, Takeshi
AU  - Azuma T
AD  - Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsuhiro Masuda, Masaya Saito, 
      Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, 
      Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, 
      Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Proton Pump Inhibitors)
RN  - EC 1.14.14.1 (CYP2C19 protein, human)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP2C19)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Amplified Fragment Length Polymorphism Analysis
MH  - Cytochrome P-450 CYP2C19/*genetics/metabolism
MH  - Esophagitis, Peptic/diagnosis/*drug therapy/genetics
MH  - Female
MH  - Gastroesophageal Reflux/diagnosis/*drug therapy/genetics
MH  - Humans
MH  - Maintenance Chemotherapy
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Restriction Fragment Length
MH  - Proton Pump Inhibitors/metabolism/*therapeutic use
MH  - Quality of Life
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
PMC - PMC5360648
OTO - NOTNLM
OT  - CYP2C19
OT  - FSSG
OT  - Gastroesophageal reflux disease
OT  - Proton pump inhibitor
OT  - Residual symptoms
COIS- Conflict-of-interest statement: The authors declare that they have no conflicts 
      of interest.
EDAT- 2017/04/05 06:00
MHDA- 2017/09/15 06:00
PMCR- 2017/03/21
CRDT- 2017/04/05 06:00
PHST- 2016/12/11 00:00 [received]
PHST- 2017/01/24 00:00 [revised]
PHST- 2017/02/17 00:00 [accepted]
PHST- 2017/04/05 06:00 [entrez]
PHST- 2017/04/05 06:00 [pubmed]
PHST- 2017/09/15 06:00 [medline]
PHST- 2017/03/21 00:00 [pmc-release]
AID - 10.3748/wjg.v23.i11.2060 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2017 Mar 21;23(11):2060-2067. doi: 
      10.3748/wjg.v23.i11.2060.