PMID- 28373889
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2017
DP  - 2017
TI  - The Effects of Modified Simiao Decoction in the Treatment of Gouty Arthritis: A 
      Systematic Review and Meta-Analysis.
PG  - 6037037
LID - 10.1155/2017/6037037 [doi]
LID - 6037037
AB  - The modified Simiao decoctions (MSD) have been wildly applied in the treatment of 
      gouty arthritis in China. However, the evidence needs to be evaluated by a 
      systematic review and meta-analysis. After filtering, twenty-four randomised, 
      controlled trials (RCTs) comparing the effects of MSD and anti-inflammation 
      medications and/or urate-lowering therapies in patients with gouty arthritis were 
      included. In comparison with anti-inflammation medications, urate-lowering 
      therapies, or coadministration of anti-inflammation medications and 
      urate-lowering therapies, MSD monotherapy significantly lowered serum uric acid 
      (p < 0.00001, mean difference = -90.62, and 95% CI [-128.38, -52.86]; p < 
      0.00001, mean difference = -91.43, and 95% CI [-122.38, -60.49]; p = 0.02, mean 
      difference = -40.30, and 95% CI [-74.24, -6.36], resp.). Compared with 
      anti-inflammation medications and/or urate-lowering therapies, MSD monotherapy 
      significantly decreased ESR (p < 0.00001; mean difference = -8.11; 95% CI 
      [-12.53, -3.69]) and CRP (p = 0.03; mean difference = -3.21; 95% CI [-6.07, 
      -0.36]). Additionally, the adverse effects (AEs) of MSD were fewer (p < 0.00001; 
      OR = 0.08; 95% CI [0.05, 0.16]). MSD are effective in the treatment of gouty 
      arthritis through anti-inflammation and lowering urate. However, the efficacy of 
      MSD should be estimated with more RCTs.
FAU - Liu, Ya-Fei
AU  - Liu YF
AUID- ORCID: 0000-0002-4141-5259
AD  - Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, 
      1 Jianshe East Road, Zhengzhou, Henan 450052, China.
FAU - Huang, Ying
AU  - Huang Y
AD  - Institute of Integrated Traditional Chinese and Western Medicine, Tongji 
      Hospital, Tongji Medical College, Huazhong University of Science and Technology, 
      1095 Jiefang Avenue, Wuhan, Hubei 430030, China.
FAU - Wen, Cai-Yu-Zhu
AU  - Wen CY
AD  - Hubei University of Chinese Medicine, 1 Huangjiahu West Road, Wuhan, Hubei 
      430065, China.
FAU - Zhang, Jun-Jun
AU  - Zhang JJ
AD  - Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, 
      1 Jianshe East Road, Zhengzhou, Henan 450052, China.
FAU - Xing, Guo-Lan
AU  - Xing GL
AD  - Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, 
      1 Jianshe East Road, Zhengzhou, Henan 450052, China.
FAU - Tu, Sheng-Hao
AU  - Tu SH
AUID- ORCID: 0000-0001-8530-270X
AD  - Institute of Integrated Traditional Chinese and Western Medicine, Tongji 
      Hospital, Tongji Medical College, Huazhong University of Science and Technology, 
      1095 Jiefang Avenue, Wuhan, Hubei 430030, China.
FAU - Chen, Zhe
AU  - Chen Z
AD  - Institute of Integrated Traditional Chinese and Western Medicine, Tongji 
      Hospital, Tongji Medical College, Huazhong University of Science and Technology, 
      1095 Jiefang Avenue, Wuhan, Hubei 430030, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170308
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC5360963
COIS- The authors declare no conflict of interests.
EDAT- 2017/04/05 06:00
MHDA- 2017/04/05 06:01
PMCR- 2017/03/08
CRDT- 2017/04/05 06:00
PHST- 2016/10/23 00:00 [received]
PHST- 2017/01/31 00:00 [revised]
PHST- 2017/02/02 00:00 [accepted]
PHST- 2017/04/05 06:00 [entrez]
PHST- 2017/04/05 06:00 [pubmed]
PHST- 2017/04/05 06:01 [medline]
PHST- 2017/03/08 00:00 [pmc-release]
AID - 10.1155/2017/6037037 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2017;2017:6037037. doi: 10.1155/2017/6037037. 
      Epub 2017 Mar 8.