PMID- 28373890
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2017
DP  - 2017
TI  - Restructuring Reward Mechanisms in Nicotine Addiction: A Pilot fMRI Study of 
      Mindfulness-Oriented Recovery Enhancement for Cigarette Smokers.
PG  - 7018014
LID - 10.1155/2017/7018014 [doi]
LID - 7018014
AB  - The primary goal of this pilot feasibility study was to examine the effects of 
      Mindfulness-Oriented Recovery Enhancement (MORE), a behavioral treatment grounded 
      in dual-process models derived from cognitive science, on frontostriatal reward 
      processes among cigarette smokers. Healthy adult (N = 13; mean (SD) age 49 +/- 
      12.2) smokers provided informed consent to participate in a 10-week study testing 
      MORE versus a comparison group (CG). All participants underwent two fMRI scans: 
      pre-tx and after 8-weeks of MORE. Emotion regulation (ER), smoking cue reactivity 
      (CR), and resting-state functional connectivity (rsFC) were assessed at each fMRI 
      visit; smoking and mood were assessed throughout. As compared to the CG, MORE 
      significantly reduced smoking (d = 2.06) and increased positive affect (d = 
      2.02). MORE participants evidenced decreased CR-BOLD response in ventral striatum 
      (VS; d = 1.57) and ventral prefrontal cortex (vPFC; d = 1.7) and increased 
      positive ER-BOLD in VS (d(VS) = 2.13) and vPFC (d(vmPFC) = 2.66). Importantly, ER 
      was correlated with smoking reduction (r's = .68 to .91) and increased positive 
      affect (r's = .52 to .61). These findings provide preliminary evidence that MORE 
      may facilitate the restructuring of reward processes and play a role in treating 
      the pathophysiology of nicotine addiction.
FAU - Froeliger, B
AU  - Froeliger B
AUID- ORCID: 0000-0002-4357-1626
AD  - Department of Neuroscience, Medical University of South Carolina, Charleston, SC, 
      USA; Department of Psychiatry, Medical University of South Carolina, Charleston, 
      SC, USA; Hollings Cancer Center, Medical University of South Carolina, 
      Charleston, SC, USA; Center for Biomedical Imaging, Medical University of South 
      Carolina, Charleston, SC, USA.
FAU - Mathew, A R
AU  - Mathew AR
AD  - Department of Preventive Medicine, Northwestern University Feinberg School of 
      Medicine, Chicago, IL, USA.
FAU - McConnell, P A
AU  - McConnell PA
AD  - Department of Neuroscience, Medical University of South Carolina, Charleston, SC, 
      USA.
FAU - Eichberg, C
AU  - Eichberg C
AD  - Department of Neuroscience, Medical University of South Carolina, Charleston, SC, 
      USA.
FAU - Saladin, M E
AU  - Saladin ME
AD  - Department of Health Sciences and Research, Medical University of South Carolina, 
      Charleston, SC, USA.
FAU - Carpenter, M J
AU  - Carpenter MJ
AD  - Department of Psychiatry, Medical University of South Carolina, Charleston, SC, 
      USA; Hollings Cancer Center, Medical University of South Carolina, Charleston, 
      SC, USA.
FAU - Garland, E L
AU  - Garland EL
AD  - College of Social Work, University of Utah, Salt Lake City, UT, USA; Huntsman 
      Cancer Institute, University of Utah, Salt Lake City, UT, USA.
LA  - eng
GR  - T32 DA007288/DA/NIDA NIH HHS/United States
GR  - R34 DA037005/DA/NIDA NIH HHS/United States
GR  - P30 CA138313/CA/NCI NIH HHS/United States
GR  - R01 DA033459/DA/NIDA NIH HHS/United States
GR  - F32 DA036947/DA/NIDA NIH HHS/United States
GR  - R01 DA038700/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20170308
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC5360937
COIS- There are no competing interests declared.
EDAT- 2017/04/05 06:00
MHDA- 2017/04/05 06:01
PMCR- 2017/03/08
CRDT- 2017/04/05 06:00
PHST- 2016/08/23 00:00 [received]
PHST- 2017/01/29 00:00 [accepted]
PHST- 2017/04/05 06:00 [entrez]
PHST- 2017/04/05 06:00 [pubmed]
PHST- 2017/04/05 06:01 [medline]
PHST- 2017/03/08 00:00 [pmc-release]
AID - 10.1155/2017/7018014 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2017;2017:7018014. doi: 10.1155/2017/7018014. 
      Epub 2017 Mar 8.