PMID- 28374186
OWN - NLM
STAT- MEDLINE
DCOM- 20180112
LR  - 20181113
IS  - 1573-5168 (Electronic)
IS  - 0920-1742 (Linking)
VI  - 43
IP  - 4
DP  - 2017 Aug
TI  - Vitamin D(3) affects innate immune status of European sea bass (Dicentrarchus 
      labrax L.).
PG  - 1161-1174
LID - 10.1007/s10695-017-0362-3 [doi]
AB  - The effects of vitamin D(3) dietary administration on certain innate immune 
      parameters on the expression of immune-related genes in head-kidney (HK) and gut 
      were investigated in European sea bass Dicentrarchus labrax. Vitamin D(3) (vD(3)) 
      was orally administered to fish in a commercial pellet food supplemented with 0 
      (control); 3750; 18,750; or 37,500 U kg(-1). Furthermore, gut histology was 
      considered. This study showed a modulation in the activities examined in fish fed 
      with the addition of vD(3). After just 2 weeks of administration, diet 
      supplementation with the vitamin resulted in increased phagocytic ability, while 
      serum peroxidase content was increased in fish fed with all experimental diets 
      after 4 weeks, no significant differences were observed in protease, 
      anti-protease, natural haemolytic complement activities and total IgM level. At 
      gene level, fbl and rbl transcripts were up-regulated in HK in fish fed with the 
      highest concentration of vD(3)-supplemented diets after 4 weeks, while in the 
      gut, an up-regulation of hep gene was observed in fish fed with the different 
      doses of vD(3). These results suggest that vD(3) may be of great interest for 
      immunostimulatory purposes in fish farms.
FAU - Dioguardi, M
AU  - Dioguardi M
AD  - Biological Chemical Pharmaceutical Sciences and Technologies, University of 
      Palermo, via Archirafi 18, Conisma, Palermo, Italy.
FAU - Guardiola, F A
AU  - Guardiola FA
AD  - Fish Nutrition & Immunobiology Group, Centro Interdisciplinar de Investigacao 
      Marinha e Ambiental (CIIMAR), Terminal de Cruzeiros do Porto de Leixoes Av. 
      General Norton de Matos s/n, 4450-208, Porto, Portugal.
FAU - Vazzana, M
AU  - Vazzana M
AD  - Biological Chemical Pharmaceutical Sciences and Technologies, University of 
      Palermo, via Archirafi 18, Conisma, Palermo, Italy.
FAU - Cuesta, A
AU  - Cuesta A
AD  - Fish Innate Immune System Group, Department of Cell Biology and Histology, 
      Faculty of Biology, Campus Regional de Excelencia Internacional "Campus Mare 
      Nostrum", University of Murcia, 30100, Murcia, Spain.
FAU - Esteban, M A
AU  - Esteban MA
AD  - Fish Innate Immune System Group, Department of Cell Biology and Histology, 
      Faculty of Biology, Campus Regional de Excelencia Internacional "Campus Mare 
      Nostrum", University of Murcia, 30100, Murcia, Spain.
FAU - Cammarata, M
AU  - Cammarata M
AD  - Biological Chemical Pharmaceutical Sciences and Technologies, University of 
      Palermo, via Archirafi 18, Conisma, Palermo, Italy. matteo.cammarata@unipa.it.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170403
PL  - Netherlands
TA  - Fish Physiol Biochem
JT  - Fish physiology and biochemistry
JID - 100955049
RN  - 0 (Vitamins)
RN  - 1C6V77QF41 (Cholecalciferol)
SB  - IM
MH  - Animal Feed/*analysis
MH  - Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Bass/*immunology
MH  - Cholecalciferol/administration & dosage/*pharmacology
MH  - Diet/*veterinary
MH  - Immunity, Innate/*drug effects
MH  - Vitamins/administration & dosage/pharmacology
OTO - NOTNLM
OT  - Cholecalciferol (vitamin D3)
OT  - European sea bass (Dicentrarchus labrax L.)
OT  - Innate immunity
OT  - Teleost
EDAT- 2017/04/05 06:00
MHDA- 2018/01/13 06:00
CRDT- 2017/04/05 06:00
PHST- 2016/09/12 00:00 [received]
PHST- 2017/03/09 00:00 [accepted]
PHST- 2017/04/05 06:00 [pubmed]
PHST- 2018/01/13 06:00 [medline]
PHST- 2017/04/05 06:00 [entrez]
AID - 10.1007/s10695-017-0362-3 [pii]
AID - 10.1007/s10695-017-0362-3 [doi]
PST - ppublish
SO  - Fish Physiol Biochem. 2017 Aug;43(4):1161-1174. doi: 10.1007/s10695-017-0362-3. 
      Epub 2017 Apr 3.