PMID- 28375680
OWN - NLM
STAT- MEDLINE
DCOM- 20170818
LR  - 20180608
IS  - 1938-5404 (Electronic)
IS  - 0033-7587 (Linking)
VI  - 187
IP  - 6
DP  - 2017 Jun
TI  - Electroacupuncture Improves Cognitive Function and Hippocampal Neurogenesis after 
      Brain Irradiation.
PG  - 672-681
LID - 10.1667/RR14561.1 [doi]
AB  - Cognitive impairments after brain irradiation seriously affect quality of life 
      for patients, and there is currently no effective treatment. In this study using 
      an irradiated rat model, the role of electroacupuncture was investigated for 
      treatment of radiation-induced brain injury. Animals received 10 Gy exposure to 
      the entire brain, and electroacupuncture was administered 3 days before 
      irradiation as well as up to 2 weeks postirradiation. Behavioral tests were 
      performed one month postirradiation, and rats were then sacrificed for histology 
      or molecular studies. Electroacupuncture markedly improved animal performance in 
      the novel place recognition test. In the emotion test, electroacupuncture reduced 
      defecation during the open-field test, and latency to consumption of food in the 
      novelty suppressed feeding test. Brain irradiation inhibited the generation of 
      immature neurons, but did not cause neural stem cell loss. Electroacupuncture 
      partially restored hippocampal neurogenesis. Electroacupuncture decreased the 
      amount of activated microglia and increased resting microglia in the hippocampus 
      after irradiation. In addition, electroacupuncture promoted mRNA and protein 
      expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. In 
      conclusion, electroacupuncture could improve cognitive function and hippocampal 
      neurogenesis after irradiation, and the protective effect of electroacupuncture 
      was associated with the modulation of microglia and upregulation of BDNF in the 
      hippocampus.
FAU - Fan, Xing-Wen
AU  - Fan XW
AD  - a   Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 
      Shanghai, China, 200032; Departments of.
AD  - b   Oncology and.
FAU - Liu, Huan-Huan
AU  - Liu HH
AD  - d   Department of Radiology, Xinhua Hospital, Shanghai Jiaotong University School 
      of Medicine, Shanghai, China 200092.
FAU - Wang, Hong-Bing
AU  - Wang HB
AD  - a   Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 
      Shanghai, China, 200032; Departments of.
AD  - b   Oncology and.
FAU - Chen, Fu
AU  - Chen F
AD  - c   Integrative Medicine and Neurobiology, State Key Laboratory of Medical 
      Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China, 
      200032; and.
FAU - Yang, Yu
AU  - Yang Y
AD  - a   Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 
      Shanghai, China, 200032; Departments of.
FAU - Chen, Yan
AU  - Chen Y
AD  - c   Integrative Medicine and Neurobiology, State Key Laboratory of Medical 
      Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China, 
      200032; and.
FAU - Guan, Shi-Kuo
AU  - Guan SK
AD  - a   Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 
      Shanghai, China, 200032; Departments of.
FAU - Wu, Kai-Liang
AU  - Wu KL
AD  - a   Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 
      Shanghai, China, 200032; Departments of.
AD  - b   Oncology and.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170404
PL  - United States
TA  - Radiat Res
JT  - Radiation research
JID - 0401245
SB  - IM
MH  - Animals
MH  - Cognition/*radiation effects
MH  - Cognition Disorders/etiology/*physiopathology/*therapy
MH  - Cranial Irradiation/adverse effects
MH  - Electroacupuncture/*methods
MH  - Electromagnetic Fields
MH  - Hippocampus/*physiopathology/radiation effects
MH  - Male
MH  - Neurogenesis/*radiation effects
MH  - Radiation Injuries/etiology/physiopathology/*therapy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Treatment Outcome
EDAT- 2017/04/05 06:00
MHDA- 2017/08/19 06:00
CRDT- 2017/04/05 06:00
PHST- 2017/04/05 06:00 [pubmed]
PHST- 2017/08/19 06:00 [medline]
PHST- 2017/04/05 06:00 [entrez]
AID - 10.1667/RR14561.1 [doi]
PST - ppublish
SO  - Radiat Res. 2017 Jun;187(6):672-681. doi: 10.1667/RR14561.1. Epub 2017 Apr 4.