PMID- 28376036
OWN - NLM
STAT- MEDLINE
DCOM- 20171010
LR  - 20180215
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 101
IP  - 9
DP  - 2017 Sep
TI  - Evaluation of Skeletal Muscle Function in Lung Transplant Candidates.
PG  - 2183-2191
LID - 10.1097/TP.0000000000001754 [doi]
AB  - BACKGROUND: Lung transplantation (LTx) is offered to older and more complex 
      patients who may be at higher risk of skeletal muscle dysfunction, but the 
      clinical implications of this remain uncertain. The study aims were to 
      characterize deficits in skeletal muscle mass, strength and physical performance, 
      and examine the associations of these deficits with clinical outcomes. METHODS: 
      Fifty LTx candidates (58% men; age, 59 +/- 9 years) were prospectively evaluated 
      for skeletal muscle deficits: muscle mass using bioelectrical impedance, 
      quadriceps, respiratory muscle and handgrip strength, and physical performance 
      with the Short Physical Performance Battery. Comparisons between number of muscle 
      deficits (low muscle mass, quadriceps strength and physical performance) and 
      6-minute walk distance (6MWD), London Chest Activity of Daily Living 
      Questionnaire, and quality of life were assessed using one-way analysis of 
      variance. Associations with pretransplant and posttransplant delisting/mortality, 
      hospital duration, and 3-month posttransplant 6MWD were evaluated using Fisher 
      exact test and Spearman correlation. RESULTS: Deficits in quadriceps strength (n 
      = 27) and physical performance (n = 24) were more common than muscle mass (n = 
      8). LTx candidates with 2 or 3 muscle deficits (42%) compared with those without 
      any deficits (26%) had worse 6MWD = -109 m (95% confidence interval [CI], -175 to 
      -43), London Chest Activity of Daily Living Questionnaire = 18 (95% CI, 7-30), 
      and St. George's Activity Domain = 12 (95% CI, 2-21). Number of muscle deficits 
      was associated with posttransplant hospital stay (r = 0.34, P = 0.04), but not 
      with delisting/mortality or posttransplant 6MWD. CONCLUSIONS: Deficits in 
      quadriceps muscle strength and physical performance are common in LTx candidates 
      and further research is needed to assess whether modifying muscle function 
      pretransplant can lead to improved clinical outcomes.
FAU - Rozenberg, Dmitry
AU  - Rozenberg D
AD  - 1 Department of Medicine, Respirology, University of Toronto, Toronto, ON, 
      Canada. 2 Lung Transplant Program, University Health Network, Toronto, ON, 
      Canada. 3 Critical Care, University Health Network, Toronto, ON, Canada. 4 
      Respirology, West Park Health Care Center, Toronto, ON, Canada. 5 Department of 
      Physical Therapy, University of Toronto, Toronto, ON, Canada.
FAU - Singer, Lianne G
AU  - Singer LG
FAU - Herridge, Margaret
AU  - Herridge M
FAU - Goldstein, Roger
AU  - Goldstein R
FAU - Wickerson, Lisa
AU  - Wickerson L
FAU - Chowdhury, Noori A
AU  - Chowdhury NA
FAU - Mathur, Sunita
AU  - Mathur S
LA  - eng
GR  - CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
SB  - IM
CIN - Transplantation. 2017 Sep;101(9):1967-1968. PMID: 29633979
MH  - Activities of Daily Living
MH  - Aged
MH  - Exercise Tolerance
MH  - Female
MH  - Hand Strength
MH  - Humans
MH  - Lung Diseases/diagnosis/*physiopathology/psychology/*surgery
MH  - *Lung Transplantation
MH  - Male
MH  - Middle Aged
MH  - *Muscle Contraction
MH  - *Muscle Strength
MH  - Organ Size
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Quadriceps Muscle/pathology/*physiopathology
MH  - Quality of Life
MH  - Respiratory Muscles/pathology/*physiopathology
MH  - Surveys and Questionnaires
MH  - Walk Test
EDAT- 2017/04/05 06:00
MHDA- 2017/10/11 06:00
CRDT- 2017/04/05 06:00
PHST- 2017/04/05 06:00 [pubmed]
PHST- 2017/10/11 06:00 [medline]
PHST- 2017/04/05 06:00 [entrez]
AID - 10.1097/TP.0000000000001754 [doi]
PST - ppublish
SO  - Transplantation. 2017 Sep;101(9):2183-2191. doi: 10.1097/TP.0000000000001754.