PMID- 28376120
OWN - NLM
STAT- MEDLINE
DCOM- 20170828
LR  - 20220331
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 4
DP  - 2017
TI  - Acupuncture for benign prostatic hyperplasia: A systematic review and 
      meta-analysis.
PG  - e0174586
LID - 10.1371/journal.pone.0174586 [doi]
LID - e0174586
AB  - PURPOSE: This systematic review and meta-analysis aims to assess the therapeutic 
      and adverse effects of acupuncture for benign prostatic hyperplasia (BPH) in 
      randomized controlled trials (RCTs). METHODS: We searched the Cochrane Central 
      Register of Controlled Trials (CENTRAL) in The Cochrane Library, MEDLINE, EMBASE, 
      the Chinese Biomedical Database, the China National Knowledge Infrastructure, the 
      VIP Database and the Wanfang Database. Parallel-group RCTs of acupuncture for men 
      with symptomatic BPH were included. Data from the included trials were extracted 
      by two independent reviewers and were analyzed with The Cochrane Collaboration 
      Review Manager software (RevMan 5.3.5) after risk of bias judgments. The primary 
      outcome measure of this review was a change in urological symptoms. RESULTS: 
      Eight RCTs, which involved 661 men with BPH, were included. Follow-up varied from 
      4 weeks to 18 months. Pooling of the data from three trials that compared 
      acupuncture with sham-acupuncture revealed that in the short term (4-6 weeks), 
      acupuncture can significantly improve IPSS (MD -1.90, 95% CI -3.58 to -0.21). A 
      sensitivity analysis of the short-term endpoint showed the same result (MD -3.01, 
      95% CI -5.19 to -0.84) with a borderline minimal clinical important difference 
      (MCID). Qmax of the short-term endpoint indicated statistically positive 
      beneficial effects of acupuncture (MD -1.78, 95%CI -3.43, -0.14). A meta-analysis 
      after medium-term follow-up (12-18 weeks) indicated no significant effect on IPSS 
      when the data from two trials were combined (MD -2.04, 95% CI -4.19, 0.10). 
      CONCLUSION: Statistically significant changes were observed in favor of 
      acupuncture in moderate to severe BPH with respect to short-term follow-up 
      endpoints. The clinical significance of these changes needs to be tested by 
      further studies with rigorous designs and longer follow-up times. TRIAL 
      REGISTRATION NUMBER: PROSPERO CRD42014013645.
FAU - Zhang, Wei
AU  - Zhang W
AUID- ORCID: 0000-0001-8541-8788
AD  - Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, China.
FAU - Ma, Liyan
AU  - Ma L
AD  - Clinical Laboratory Center. Beijing Friendship Hospital, Capital Medical 
      University, Beijing, China.
FAU - Bauer, Brent A
AU  - Bauer BA
AD  - Department of Medicine. Mayo Clinic, Rochester, Minnesota, United States of 
      America.
FAU - Liu, Zhishun
AU  - Liu Z
AD  - Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, China.
FAU - Lu, Yao
AU  - Lu Y
AD  - Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20170404
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - *Acupuncture Therapy/adverse effects/methods
MH  - Humans
MH  - Male
MH  - Prostatic Hyperplasia/physiopathology/*therapy
MH  - Randomized Controlled Trials as Topic
MH  - Treatment Outcome
PMC - PMC5380320
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/04/05 06:00
MHDA- 2017/08/29 06:00
PMCR- 2017/04/04
CRDT- 2017/04/05 06:00
PHST- 2017/01/04 00:00 [received]
PHST- 2017/03/09 00:00 [accepted]
PHST- 2017/04/05 06:00 [entrez]
PHST- 2017/04/05 06:00 [pubmed]
PHST- 2017/08/29 06:00 [medline]
PHST- 2017/04/04 00:00 [pmc-release]
AID - PONE-D-17-00425 [pii]
AID - 10.1371/journal.pone.0174586 [doi]
PST - epublish
SO  - PLoS One. 2017 Apr 4;12(4):e0174586. doi: 10.1371/journal.pone.0174586. 
      eCollection 2017.