PMID- 28376368
OWN - NLM
STAT- MEDLINE
DCOM- 20180110
LR  - 20181202
IS  - 1872-6976 (Electronic)
IS  - 0167-4943 (Linking)
VI  - 71
DP  - 2017 Jul
TI  - Brain-derived neurotrophic factor plasma levels are increased in older women 
      after an acute episode of low back pain.
PG  - 75-82
LID - S0167-4943(17)30201-7 [pii]
LID - 10.1016/j.archger.2017.03.005 [doi]
AB  - BACKGROUND: Low back pain (LBP) is a growing public health problem in old age, 
      and it is associated with disabling pain and depressive disorders. We compared 
      brain-derived neurotrophic factor (BDNF) plasma levels, a key neurotrophin in 
      pain modulation, between older women after an acute episode of LBP and 
      age-matched pain-free controls, and investigated potential differences in BDNF 
      levels between controls and LBP subgroups based on pain severity, presence of 
      depressive symptoms and use of analgesic and antidepressant drugs. METHODS: A 
      total of 221 participants (154 with LBP and 67 pain-free) were studied. A 
      comprehensive assessment of sociodemographic and clinical variables was conducted 
      including pain severity (11-point NRS), depressive symptoms (GDS-15), age, body 
      mass index, physical activity and total number of comorbidities and medications 
      in use. RESULTS: BDNF levels in LBP group were significantly higher than controls 
      (7515.9+/-3021.2; Md=7116.0 vs 6331.8+/-3364.0; Md=5897.5pg/mL, P=0.005). LBP 
      subgroups exhibited higher BDNF levels than controls, regardless of pain 
      severity, presence of depressive symptoms and use of analgesic drugs. BDNF levels 
      were significantly higher in LBP subgroup without use of antidepressant drugs 
      compared to both controls and LBP subgroup with use of antidepressant drugs. 
      DISCUSSION: This study provides evidence that older women with acute low back 
      pain exhibit higher BDNF plasma levels compared to pain-free controls. Subgroup 
      comparisons suggest that use of pain-relief drugs may influence BDNF levels. The 
      study results offer a novel target for research on mechanisms of back pain in 
      older adults.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Diz, Juliano Bergamaschine Mata
AU  - Diz JBM
AD  - Department of Physical Therapy, Postgraduate Program in Rehabilitation Sciences, 
      Universidade Federal de Minas Gerais, 6627 Antonio Carlos Avenue, 31270-901, Belo 
      Horizonte, Minas Gerais, Brazil. Electronic address: julianodiz@gmail.com.
FAU - de Souza Moreira, Bruno
AU  - de Souza Moreira B
AD  - Department of Physical Therapy, Postgraduate Program in Rehabilitation Sciences, 
      Universidade Federal de Minas Gerais, 6627 Antonio Carlos Avenue, 31270-901, Belo 
      Horizonte, Minas Gerais, Brazil. Electronic address: brunosouzamoreira@gmail.com.
FAU - Felicio, Diogo Carvalho
AU  - Felicio DC
AD  - Department of Physical Therapy, Universidade Federal de Juiz de Fora, s/n Eugenio 
      do Nascimento Avenue, 36038-330, Juiz de Fora, Minas Gerais, Brazil. Electronic 
      address: diogofelicio@yahoo.com.br.
FAU - Teixeira, Luiza Faria
AU  - Teixeira LF
AD  - Department of Physical Therapy, Universidade do Vale do Sapucai, 320 Coronel 
      Alfredo Custodio de Paula Avenue, 37550-000, Pouso Alegre, Minas Gerais, Brazil. 
      Electronic address: luizaft@yahoo.com.br.
FAU - de Jesus-Moraleida, Fabianna Resende
AU  - de Jesus-Moraleida FR
AD  - Department of Physical Therapy, Faculty of Medicine, Universidade Federal do 
      Ceara, 949 Alexandre Baruna Street, 60430-160, Fortaleza, Ceara, Brazil. 
      Electronic address: fabiannamoraleida@gmail.com.
FAU - de Queiroz, Barbara Zille
AU  - de Queiroz BZ
AD  - Department of Physical Therapy, Postgraduate Program in Rehabilitation Sciences, 
      Universidade Federal de Minas Gerais, 6627 Antonio Carlos Avenue, 31270-901, Belo 
      Horizonte, Minas Gerais, Brazil. Electronic address: babzille@gmail.com.
FAU - Pereira, Daniele Sirineu
AU  - Pereira DS
AD  - Department of Physical Therapy, Universidade Federal de Alfenas, 2600 Jovino 
      Fernandes Sales Avenue, 31270-901, Alfenas, Minas Gerais, Brazil. Electronic 
      address: daniele.sirineu@gmail.com.
FAU - Pereira, Leani Souza Maximo
AU  - Pereira LSM
AD  - Department of Physical Therapy, Postgraduate Program in Rehabilitation Sciences, 
      Universidade Federal de Minas Gerais, 6627 Antonio Carlos Avenue, 31270-901, Belo 
      Horizonte, Minas Gerais, Brazil. Electronic address: leanismp.bh@terra.com.br.
LA  - eng
PT  - Journal Article
DEP - 20170322
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Antidepressive Agents/therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cross-Sectional Studies
MH  - Depression/blood
MH  - Female
MH  - Humans
MH  - Low Back Pain/*blood
MH  - Middle Aged
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Depressive symptoms
OT  - Low back pain
OT  - Older adults
OT  - Pain modulation
EDAT- 2017/04/05 06:00
MHDA- 2018/01/11 06:00
CRDT- 2017/04/05 06:00
PHST- 2016/10/03 00:00 [received]
PHST- 2017/03/08 00:00 [revised]
PHST- 2017/03/17 00:00 [accepted]
PHST- 2017/04/05 06:00 [pubmed]
PHST- 2018/01/11 06:00 [medline]
PHST- 2017/04/05 06:00 [entrez]
AID - S0167-4943(17)30201-7 [pii]
AID - 10.1016/j.archger.2017.03.005 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2017 Jul;71:75-82. doi: 10.1016/j.archger.2017.03.005. 
      Epub 2017 Mar 22.