PMID- 28376540
OWN - NLM
STAT- MEDLINE
DCOM- 20180320
LR  - 20180320
IS  - 1439-7803 (Electronic)
IS  - 0044-2771 (Linking)
VI  - 55
IP  - 6
DP  - 2017 Jun
TI  - Update on cholangiocarcinoma: potential impact of genomic studies on clinical 
      management.
PG  - 575-581
LID - 10.1055/s-0043-102581 [doi]
AB  - The term cholangiocarcinoma (CCA) comprises neoplasms of the intrahepatic, 
      perihilar, and distal bile duct. Five-year survival rates of patients with CCA 
      are below 20 %, and no targeted therapy could prove a benefit in comparison to 
      the standard treatment of cisplatinum and gemcitabine. In recent years, next 
      generation sequencing studies revealed a profound genomic heterogeneity of CCA 
      subtypes potentially affecting the design of future therapy trials. This review 
      provides a concise update on current clinical management of CCA including data of 
      recent genomic studies and differences between CCA subtypes.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Walter, Dirk
AU  - Walter D
AD  - Department of Internal Medicine I, Johann Wolfgang Goethe-University Hospital, 
      Frankfurt, Germany.
FAU - Hartmann, Sylvia
AU  - Hartmann S
AD  - Johann Wolfgang Goethe-University Hospital, Dr. Senckenberg Institute of 
      Pathology, Frankfurt, Germany.
FAU - Waidmann, Oliver
AU  - Waidmann O
AD  - Department of Internal Medicine I, Johann Wolfgang Goethe-University Hospital, 
      Frankfurt, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
TT  - Update zum Cholangiokarzinom: potentieller Einfluss genomischer Studien auf das 
      klinische Management.
DEP - 20170404
PL  - Germany
TA  - Z Gastroenterol
JT  - Zeitschrift fur Gastroenterologie
JID - 0033370
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Bile Duct Neoplasms/diagnosis/*genetics/*therapy
MH  - Biomarkers, Tumor/*genetics
MH  - Cholangiocarcinoma/diagnosis/*genetics/*therapy
MH  - Early Detection of Cancer/*methods
MH  - Evidence-Based Medicine
MH  - Genetic Markers/genetics
MH  - Genetic Predisposition to Disease/genetics
MH  - Genetic Testing/*methods
MH  - Genomics/trends
MH  - Humans
MH  - Treatment Outcome
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2017/04/05 06:00
MHDA- 2018/03/21 06:00
CRDT- 2017/04/05 06:00
PHST- 2017/04/05 06:00 [pubmed]
PHST- 2018/03/21 06:00 [medline]
PHST- 2017/04/05 06:00 [entrez]
AID - 10.1055/s-0043-102581 [doi]
PST - ppublish
SO  - Z Gastroenterol. 2017 Jun;55(6):575-581. doi: 10.1055/s-0043-102581. Epub 2017 
      Apr 4.