PMID- 28377310
OWN - NLM
STAT- MEDLINE
DCOM- 20180521
LR  - 20180521
IS  - 1469-0691 (Electronic)
IS  - 1198-743X (Linking)
VI  - 23
IP  - 12
DP  - 2017 Dec
TI  - Risk factors for extended-spectrum beta-lactamase-producing Escherichia coli urinary 
      tract infection in the community in Denmark: a case-control study.
PG  - 952-960
LID - S1198-743X(17)30196-9 [pii]
LID - 10.1016/j.cmi.2017.03.026 [doi]
AB  - OBJECTIVE: To verify the role of proton pump inhibitors (PPI) and nitrofurantoin, 
      which have appeared as novel risk factors for carriage of extended-spectrum 
      beta-lactamase (ESBL) -producing Escherichia coli, as risk factors for ESBL E. coli 
      urinary tract infection (UTI). We included known risk factors to ascertain 
      whether our findings are comparable with those of previous studies. METHODS: 
      Population-based case-control study including 339 cases with community-onset ESBL 
      E. coli UTI in 2007-2012, 3390 non-ESBL E. coli UTI controls and 3390 population 
      controls. We investigated potential risk factors by estimating ORs and 95% CIs 
      adjusting for sex, age and co-morbidity. RESULTS: Comparing cases with non-ESBL 
      E. coli UTI, PPI use yielded an OR of 1.6 (95% CI 1.2-2.0) and antibiotic 
      exposure gave an OR of 1.4 (95% CI 1.1-1.8); these were driven by nitrofurantoin 
      (OR 1.8; 95% CI 1.3-2.6) and macrolides (OR 1.7; 95% CI 1.2-2.3). Other risk 
      factors included previous hospitalization with one or two and more than two 
      hospitalizations versus none yielding ORs of 1.9 (95% CI 1.4-2.5) and 4.6 (95% CI 
      3.2-6.8), recent surgery (OR 2.0; 95% CI 1.5-2.8), renal disease (OR 2.2; 95% CI 
      1.4-3.4), chronic pulmonary disease (OR 1.4; 95% CI 1.0-2.0) and cancer (OR 1.5; 
      95% CI 1.1-2.1). Comparing cases with population controls, we found that most 
      risk factors were also risk factors for non-ESBL UTI. CONCLUSIONS: ESBL E. coli 
      UTI were associated with previous hospitalization and surgery. Nitrofurantoin and 
      macrolides augmented the risk. PPIs had a moderate effect but may be important 
      facilitators of ESBL carriage due to their widespread use.
CI  - Copyright (c) 2017 European Society of Clinical Microbiology and Infectious 
      Diseases. Published by Elsevier Ltd. All rights reserved.
FAU - Sogaard, M
AU  - Sogaard M
AD  - Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark. 
      Electronic address: mette.soegaard@rn.au.dk.
FAU - Heide-Jorgensen, U
AU  - Heide-Jorgensen U
AD  - Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
FAU - Vandenbroucke, J P
AU  - Vandenbroucke JP
AD  - Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 
      Department of Clinical Epidemiology, Leiden University, Utrecht, The Netherlands.
FAU - Schonheyder, H C
AU  - Schonheyder HC
AD  - Department of Clinical Microbiology, Aalborg University Hospital, Aalborg, 
      Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
FAU - Vandenbroucke-Grauls, C M J E
AU  - Vandenbroucke-Grauls CMJE
AD  - Department of Medical Microbiology & Infection Control, VU University Medical 
      Centre, Amsterdam, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20170401
PL  - England
TA  - Clin Microbiol Infect
JT  - Clinical microbiology and infection : the official publication of the European 
      Society of Clinical Microbiology and Infectious Diseases
JID - 9516420
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Case-Control Studies
MH  - Community-Acquired Infections/drug therapy/epidemiology/etiology/microbiology
MH  - Denmark/epidemiology
MH  - Escherichia coli Infections/drug therapy/epidemiology/*etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Urinary Tract Infections/drug therapy/epidemiology/*etiology/microbiology
MH  - Young Adult
MH  - beta-Lactam Resistance
OTO - NOTNLM
OT  - Community-onset
OT  - Extended-spectrum beta-lactamase
OT  - Hospitalization
OT  - Risk factors
OT  - Urinary tract infection
EDAT- 2017/04/06 06:00
MHDA- 2018/05/22 06:00
CRDT- 2017/04/06 06:00
PHST- 2016/12/21 00:00 [received]
PHST- 2017/03/28 00:00 [revised]
PHST- 2017/03/29 00:00 [accepted]
PHST- 2017/04/06 06:00 [pubmed]
PHST- 2018/05/22 06:00 [medline]
PHST- 2017/04/06 06:00 [entrez]
AID - S1198-743X(17)30196-9 [pii]
AID - 10.1016/j.cmi.2017.03.026 [doi]
PST - ppublish
SO  - Clin Microbiol Infect. 2017 Dec;23(12):952-960. doi: 10.1016/j.cmi.2017.03.026. 
      Epub 2017 Apr 1.