PMID- 28377693
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 1662-5099 (Print)
IS  - 1662-5099 (Electronic)
IS  - 1662-5099 (Linking)
VI  - 10
DP  - 2017
TI  - Inhibition of Mammalian Target of Rapamycin (mTOR) Signaling in the Insular 
      Cortex Alleviates Neuropathic Pain after Peripheral Nerve Injury.
PG  - 79
LID - 10.3389/fnmol.2017.00079 [doi]
LID - 79
AB  - Injury of peripheral nerves can trigger neuropathic pain, producing allodynia and 
      hyperalgesia via peripheral and central sensitization. Recent studies have 
      focused on the role of the insular cortex (IC) in neuropathic pain. Because the 
      IC is thought to store pain-related memories, translational regulation in this 
      structure may reveal novel targets for controlling chronic pain. Signaling via 
      mammalian target of rapamycin (mTOR), which is known to control mRNA translation 
      and influence synaptic plasticity, has been studied at the spinal level in 
      neuropathic pain, but its role in the IC under these conditions remains elusive. 
      Therefore, this study was conducted to determine the role of mTOR signaling in 
      neuropathic pain and to assess the potential therapeutic effects of rapamycin, an 
      inhibitor of mTORC1, in the IC of rats with neuropathic pain. Mechanical 
      allodynia was assessed in adult male Sprague-Dawley rats after neuropathic 
      surgery and following microinjections of rapamycin into the IC on postoperative 
      days (PODs) 3 and 7. Optical recording was conducted to observe the neural 
      responses of the IC to peripheral stimulation. Rapamycin reduced mechanical 
      allodynia and downregulated the expression of postsynaptic density protein 95 
      (PSD95), decreased neural excitability in the IC, thereby inhibiting neuropathic 
      pain-induced synaptic plasticity. These findings suggest that mTOR signaling in 
      the IC may be a critical molecular mechanism modulating neuropathic pain.
FAU - Kwon, Minjee
AU  - Kwon M
AD  - Department of Physiology, Yonsei University College of MedicineSeoul, South 
      Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College 
      of MedicineSeoul, South Korea.
FAU - Han, Jeongsoo
AU  - Han J
AD  - Department of Physiology, Yonsei University College of MedicineSeoul, South 
      Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College 
      of MedicineSeoul, South Korea.
FAU - Kim, Un Jeng
AU  - Kim UJ
AD  - Department of Physiology, Yonsei University College of Medicine Seoul, South 
      Korea.
FAU - Cha, Myeounghoon
AU  - Cha M
AD  - Department of Physiology, Yonsei University College of Medicine Seoul, South 
      Korea.
FAU - Um, Sun Woo
AU  - Um SW
AD  - Department of Physiology, Yonsei University College of MedicineSeoul, South 
      Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College 
      of MedicineSeoul, South Korea.
FAU - Bai, Sun Joon
AU  - Bai SJ
AD  - Department of Anesthesiology and Pain Medicine, Yonsei University College of 
      Medicine Seoul, South Korea.
FAU - Hong, Seong-Karp
AU  - Hong SK
AD  - Division of Bio and Health Sciences, Mokwon University Daejeon, South Korea.
FAU - Lee, Bae Hwan
AU  - Lee BH
AD  - Department of Physiology, Yonsei University College of MedicineSeoul, South 
      Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College 
      of MedicineSeoul, South Korea; Brain Research Institute and Epilepsy Research 
      Institute, Yonsei University College of MedicineSeoul, South Korea.
LA  - eng
PT  - Journal Article
DEP - 20170321
PL  - Switzerland
TA  - Front Mol Neurosci
JT  - Frontiers in molecular neuroscience
JID - 101477914
PMC - PMC5359287
OTO - NOTNLM
OT  - insular cortex
OT  - mTOR
OT  - neuropathic pain
OT  - rapamycin
OT  - synaptic plasticity
EDAT- 2017/04/06 06:00
MHDA- 2017/04/06 06:01
PMCR- 2017/01/01
CRDT- 2017/04/06 06:00
PHST- 2016/12/09 00:00 [received]
PHST- 2017/03/06 00:00 [accepted]
PHST- 2017/04/06 06:00 [entrez]
PHST- 2017/04/06 06:00 [pubmed]
PHST- 2017/04/06 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fnmol.2017.00079 [doi]
PST - epublish
SO  - Front Mol Neurosci. 2017 Mar 21;10:79. doi: 10.3389/fnmol.2017.00079. eCollection 
      2017.