PMID- 28378554 OWN - NLM STAT- MEDLINE DCOM- 20170908 LR - 20221207 IS - 1598-6357 (Electronic) IS - 1011-8934 (Print) IS - 1011-8934 (Linking) VI - 32 IP - 5 DP - 2017 May TI - Reference Values and Utility of Serum Total Immunoglobulin E for Predicting Atopy and Allergic Diseases in Korean Schoolchildren. PG - 803-809 LID - 10.3346/jkms.2017.32.5.803 [doi] AB - The present study aimed to investigate the distribution of total serum immunoglobulin E (IgE) levels in Korean schoolchildren and to evaluate its utility in the prediction of atopy and allergic diseases. A nationwide, cross-sectional survey was conducted in first grade students from randomly selected elementary and middle schools. Total IgE levels were measured by ImmunoCAP. Skin prick tests were performed for 18 common inhalant allergens to determine the presence of atopy. Children aged 12-13 years and parents of children aged 6-7 years were asked to complete questionnaire assessing allergic diseases. The cut-off levels of total IgE were determined by analyzing receiver operating characteristic curves. The median total IgE level was 86.7 kU/L (range: 1.5-4,523.1) in 3,753 children aged 6-7 years and 94.7 kU/L (range: 1.5-3,000.0) in 3,930 children aged 12-13 years. Total IgE concentrations were higher in children with atopy or allergic diseases than in those without (all P < 0.001). At the cut-off value of 127.7 kU/L, sensitivity, specificity, and positive and negative predictive values (PPV and NPV) were 67.1%, 75.4%, 65.4%, and 76.7%, respectively, in elementary schoolchildren. At the cut-off value of 63.0 kU/L, sensitivity, specificity, PPV, and NPV were 81.9%, 66.6%, 75.0%, and 75.1%, respectively, in middle schoolchildren. PPV and NPV were >/= 70% when cut-offs of 258.8 kU/L and 38.4 kU/L were used for the diagnosis of atopy in 6-7 year-olds and 12-13 year-olds, respectively. This nationwide population-based study provided the first normal reference ranges of total IgE in Korean schoolchildren. CI - (c) 2017 The Korean Academy of Medical Sciences. FAU - Kim, Hye Young AU - Kim HY AUID- ORCID: 0000-0001-7125-8840 AD - Department of Pediatrics, Medical Research Institute of Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea. FAU - Choi, Jaehee AU - Choi J AUID- ORCID: 0000-0002-6651-4480 AD - Department of Pediatrics, Samyook Medical Center, Seoul, Korea. FAU - Ahn, Kangmo AU - Ahn K AUID- ORCID: 0000-0001-7751-9829 AD - Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. AD - Environmental Health Center for Atopic Diseases, Samsung Medical Center, Seoul, Korea. FAU - Hahm, Myung Il AU - Hahm MI AUID- ORCID: 0000-0002-4790-3739 AD - Department of Health Administration and Management, Soonchunhyang University College of Medical Science, Asan, Korea. FAU - Lee, So Yeon AU - Lee SY AUID- ORCID: 0000-0002-2499-0702 AD - Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea. FAU - Kim, Woo Kyung AU - Kim WK AUID- ORCID: 0000-0001-8730-010X AD - Department of Pediatrics, Inje University College of Medicine, Seoul, Korea. FAU - Chae, Yoomi AU - Chae Y AUID- ORCID: 0000-0003-1071-6099 AD - Department of Occupational and Environmental Medicine, College of Medicine, Dankook University, Cheonan, Korea. FAU - Park, Yong Mean AU - Park YM AUID- ORCID: 0000-0002-2586-584X AD - Department of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea. FAU - Han, Man Yong AU - Han MY AUID- ORCID: 0000-0002-9077-5779 AD - Department of Pediatrics, CHA University School of Medicine, Seongnam, Korea. FAU - Lee, Kee Jae AU - Lee KJ AUID- ORCID: 0000-0002-9499-5971 AD - Department of Information and Statistics, Korea National Open University, Seoul, Korea. FAU - Kwon, Ho Jang AU - Kwon HJ AUID- ORCID: 0000-0003-3029-5674 AD - Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, Korea. FAU - Kim, Seonwoo AU - Kim S AUID- ORCID: 0000-0002-9236-560X AD - Biostatistics and Clinical Epidemiology Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea. FAU - Yoo, Heejin AU - Yoo H AUID- ORCID: 0000-0003-4341-6906 AD - Biostatistics and Clinical Epidemiology Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea. FAU - Kim, Jihyun AU - Kim J AUID- ORCID: 0000-0001-8493-2881 AD - Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. AD - Environmental Health Center for Atopic Diseases, Samsung Medical Center, Seoul, Korea. jhlovechild@gmail.com. LA - eng PT - Journal Article PL - Korea (South) TA - J Korean Med Sci JT - Journal of Korean medical science JID - 8703518 RN - 0 (Allergens) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Adolescent MH - Allergens/analysis/immunology MH - Area Under Curve MH - Asian People MH - Child MH - Cross-Sectional Studies MH - Dermatitis, Atopic/*diagnosis/epidemiology MH - Female MH - Humans MH - Immunoglobulin E/*blood MH - Inhalation MH - Male MH - Prevalence MH - ROC Curve MH - Republic of Korea/epidemiology MH - Rhinitis, Allergic/*diagnosis/epidemiology MH - Sensitivity and Specificity MH - Skin Tests PMC - PMC5383613 OTO - NOTNLM OT - Allergy OT - Atopy OT - Immunoglobulin E OT - Korea OT - Schoolchildren COIS- The authors have no potential conflicts of interest to disclose. EDAT- 2017/04/06 06:00 MHDA- 2017/09/09 06:00 PMCR- 2017/05/01 CRDT- 2017/04/06 06:00 PHST- 2016/09/09 00:00 [received] PHST- 2017/01/27 00:00 [accepted] PHST- 2017/04/06 06:00 [entrez] PHST- 2017/04/06 06:00 [pubmed] PHST- 2017/09/09 06:00 [medline] PHST- 2017/05/01 00:00 [pmc-release] AID - 32.803 [pii] AID - 10.3346/jkms.2017.32.5.803 [doi] PST - ppublish SO - J Korean Med Sci. 2017 May;32(5):803-809. doi: 10.3346/jkms.2017.32.5.803.