PMID- 28379390
OWN - NLM
STAT- MEDLINE
DCOM- 20170505
LR  - 20201209
IS  - 1460-2377 (Electronic)
IS  - 0953-8178 (Linking)
VI  - 29
IP  - 2
DP  - 2017 Feb 1
TI  - Arid5a-deficient mice are highly resistant to bleomycin-induced lung injury.
PG  - 79-85
LID - 10.1093/intimm/dxx004 [doi]
AB  - Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are among 
      the major causes of death worldwide due to acute inflammation in the lung. 
      AT-rich interactive domain-containing 5a (Arid5a) is an RNA-binding protein 
      involved in inflammatory autoimmune disease through post-transcriptional control 
      of Il6, Stat3 and Tbx21 gene expression. We found that Arid5a-deficient mice were 
      highly refractory to bleomycin (BLM)-induced lethality. Arid5a deficiency 
      suppressed lung pathology, cytokine production (especially, IL-6), and clinical 
      symptoms in BLM-treated mice. Production of reactive oxygen species (ROS) in 
      response to BLM-induced cellular damage was inhibited in Arid5a-deficient mice, 
      potentially affecting the level of oxidized 
      1-palmitoyl-2-arachidonoyl-phosphaticylcholine (OxPAPC) production. OxPAPC, which 
      is supposed to be a TLR4/TLR2 ligand, stimulated expression of the Arid5a and Il6 
      genes. Thus, reduction of ROS production in Arid5a-deficient mice could mitigate 
      OxPAPC production, which in turn decreases IL-6 production in vivo due to 
      dysregulated post-transcriptional regulation by loss of Arid5a. Therefore, the 
      control of Arid5a expression represents a potential therapeutic target for 
      treatment of ALI and ARDS.
CI  - (c) The Japanese Society for Immunology. 2017. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Dubey, Praveen Kumar
AU  - Dubey PK
AD  - Laboratory of Immune Regulation, World Premier International-Immunology Frontier 
      Research Center, Osaka University, 3-1 Yamadaoka, Suita-City, Osaka 565-0871, 
      Japan.
FAU - Masuda, Kazuya
AU  - Masuda K
AD  - Laboratory of Immune Regulation, World Premier International-Immunology Frontier 
      Research Center, Osaka University, 3-1 Yamadaoka, Suita-City, Osaka 565-0871, 
      Japan.
FAU - Nyati, Kishan Kumar
AU  - Nyati KK
AD  - Laboratory of Immune Regulation, World Premier International-Immunology Frontier 
      Research Center, Osaka University, 3-1 Yamadaoka, Suita-City, Osaka 565-0871, 
      Japan.
FAU - -Uz Zaman, Mohammad Mahabub
AU  - -Uz Zaman MM
AD  - Laboratory of Immune Regulation, World Premier International-Immunology Frontier 
      Research Center, Osaka University, 3-1 Yamadaoka, Suita-City, Osaka 565-0871, 
      Japan.
FAU - Chalise, Jaya Prakash
AU  - Chalise JP
AD  - Laboratory of Immune Regulation, World Premier International-Immunology Frontier 
      Research Center, Osaka University, 3-1 Yamadaoka, Suita-City, Osaka 565-0871, 
      Japan.
FAU - Millrine, David
AU  - Millrine D
AD  - Laboratory of Immune Regulation, World Premier International-Immunology Frontier 
      Research Center, Osaka University, 3-1 Yamadaoka, Suita-City, Osaka 565-0871, 
      Japan.
FAU - Kai, Wang
AU  - Kai W
AD  - Laboratory of Immune Regulation, World Premier International-Immunology Frontier 
      Research Center, Osaka University, 3-1 Yamadaoka, Suita-City, Osaka 565-0871, 
      Japan.
FAU - Ripley, Barry
AU  - Ripley B
AD  - Laboratory of Immune Regulation, World Premier International-Immunology Frontier 
      Research Center, Osaka University, 3-1 Yamadaoka, Suita-City, Osaka 565-0871, 
      Japan.
FAU - Kishimoto, Tadamitsu
AU  - Kishimoto T
AD  - Laboratory of Immune Regulation, World Premier International-Immunology Frontier 
      Research Center, Osaka University, 3-1 Yamadaoka, Suita-City, Osaka 565-0871, 
      Japan.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int Immunol
JT  - International immunology
JID - 8916182
RN  - 0 (Arid5a protein, mouse)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Interleukin-6)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Transcription Factors)
RN  - 11056-06-7 (Bleomycin)
SB  - IM
MH  - Acute Lung Injury/chemically induced/*immunology
MH  - Animals
MH  - Bleomycin/administration & dosage
MH  - DNA-Binding Proteins/*genetics
MH  - Humans
MH  - Interleukin-6/metabolism
MH  - Lung/*pathology/physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Pneumonia/*immunology/therapy
MH  - Reactive Oxygen Species/metabolism
MH  - Respiratory Distress Syndrome/*immunology/therapy
MH  - Transcription Factors/*genetics
OTO - NOTNLM
OT  - IL-6
OT  - OxPAPC
OT  - ROS
OT  - acute lung injury
OT  - acute respiratory distress syndrome
EDAT- 2017/04/06 06:00
MHDA- 2017/05/06 06:00
CRDT- 2017/04/06 06:00
PHST- 2016/09/13 00:00 [received]
PHST- 2017/03/23 00:00 [accepted]
PHST- 2017/04/06 06:00 [pubmed]
PHST- 2017/05/06 06:00 [medline]
PHST- 2017/04/06 06:00 [entrez]
AID - 3098295 [pii]
AID - 10.1093/intimm/dxx004 [doi]
PST - ppublish
SO  - Int Immunol. 2017 Feb 1;29(2):79-85. doi: 10.1093/intimm/dxx004.