PMID- 28379599
OWN - NLM
STAT- MEDLINE
DCOM- 20170726
LR  - 20180320
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 21
IP  - 1 Suppl
DP  - 2017 Mar
TI  - Hepatotoxicity associated with illicit use of anabolic androgenic steroids in 
      doping.
PG  - 7-16
LID - 12427 [pii]
AB  - Anabolic Androgenic Steroids (AAS) abuse and misuse is nowadays a harmful habit 
      involving both professional or recreational athletes, as well as general 
      population. AAS are also frequently present in over-the-counter dietary 
      supplements without being declared in the list of ingredients, leaving consumers 
      unaware of the risks of adverse effects. Indeed, health risks of AAS consumption 
      in pharmaceutical preparations or dietary complements seem still underestimated 
      and under-reported. The variety of complications due to AAS misuse involves 
      cardiovascular, central nervous, musculoskeletal and genitourinary systems of 
      both males and females; psychiatric and behavioral effects, damages to metabolic 
      system, skin and mainly liver. For instance, relevant concern has been raised by 
      the AAS hepatotoxicity including adenoma, hepatocellular carcinoma, cholestasis, 
      and peliosis hepatis. The present review reports the information available on the 
      hepatotoxic effects of AAS use in professional and amateur athletes.
FAU - Solimini, R
AU  - Solimini R
AD  - Department of Therapeutic Research and Medicines Evaluation, Drug Abuse and 
      Doping Unit, Istituto Superiore di Sanita, Rome, Italy. renata.solimini@iss.it.
FAU - Rotolo, M C
AU  - Rotolo MC
FAU - Mastrobattista, L
AU  - Mastrobattista L
FAU - Mortali, C
AU  - Mortali C
FAU - Minutillo, A
AU  - Minutillo A
FAU - Pichini, S
AU  - Pichini S
FAU - Pacifici, R
AU  - Pacifici R
FAU - Palmi, I
AU  - Palmi I
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Anabolic Agents)
RN  - 0 (Steroids)
SB  - IM
MH  - Anabolic Agents/*adverse effects
MH  - Athletes
MH  - Carcinoma, Hepatocellular/*chemically induced
MH  - *Chemical and Drug Induced Liver Injury
MH  - *Doping in Sports
MH  - Humans
MH  - Liver Neoplasms
MH  - Steroids
EDAT- 2017/04/06 06:00
MHDA- 2017/07/27 06:00
CRDT- 2017/04/06 06:00
PHST- 2017/04/06 06:00 [entrez]
PHST- 2017/04/06 06:00 [pubmed]
PHST- 2017/07/27 06:00 [medline]
AID - 12427 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2017 Mar;21(1 Suppl):7-16.