PMID- 28380135 OWN - NLM STAT- MEDLINE DCOM- 20170905 LR - 20181113 IS - 1678-4170 (Electronic) IS - 0066-782X (Print) IS - 0066-782X (Linking) VI - 108 IP - 4 DP - 2017 Apr TI - MCP-1 Levels are Associated with Cardiac Remodeling but not with Resistant Hypertension. PG - 331-338 LID - 10.5935/abc.20170033 [doi] AB - BACKGROUND: Hypertension is a chronic, low-grade inflammation process associated with the release of cytokines and development of target organ damage. Deregulated monocyte chemoattractant protein-1 (MCP-1) levels have been associated with high blood pressure and cardiovascular complications; however, the mechanisms involved are complex and not fully understood. OBJECTIVE: This study aimed to compare the levels of MCP-1 in patients with resistant (RH) versus mild-to-moderate (HTN) hypertension and their association with the presence or absence of left ventricular hypertrophy (LVH) in all hypertensive subjects. METHODS: We enrolled 256 hypertensive subjects: 120 RH and 136 HTN, investigating the relationship between circulating MCP-1 levels and blood pressure, biochemical data, hematologic profile, and cardiac damage within the RH and HTN groups. Plasma MCP-1 levels were measured by ELISA and LVH was assessed by echocardiography. RESULTS: We found no difference in MCP-1 levels between RH and HTN subjects. On the other hand, we encountered lower MCP-1 levels in patients with LVH (105 pg/mL [100 - 260 pg/mL] versus 136 pg/mL (100 - 200 pg/mL), p = 0.005, respectively] compared with those without LVH. A logistic regression model adjusted for body mass index (BMI), age, race, aldosterone levels, and presence of diabetes and RH demonstrated that median levels of MCP-1 (2.55 pg/mL [1.22 - 5.2 pg/mL], p = 0.01) were independently associated with LVH in the entire hypertensive population. CONCLUSION: Since MCP-1 levels were similar in both RH and HTN subjects and decreased in hypertensive patients with existing LVH, our study suggests a possible downregulation in MCP-1 levels in hypertensive individuals with LVH, regardless of hypertension strata. FAU - Ritter, Alessandra Mileni Versuti AU - Ritter AMV AD - Universidade Estadual de Campinas (UNICAMP), Campinas, SP - Brazil. FAU - Faria, Ana Paula Cabral de AU - Faria APC AD - Universidade Estadual de Campinas (UNICAMP), Campinas, SP - Brazil. FAU - Sabbatini, Andrea AU - Sabbatini A AD - Universidade Estadual de Campinas (UNICAMP), Campinas, SP - Brazil. FAU - Correa, Nathalia Batista AU - Correa NB AD - Universidade Estadual de Campinas (UNICAMP), Campinas, SP - Brazil. FAU - Brunelli, Veridiana AU - Brunelli V AD - Universidade Estadual de Campinas (UNICAMP), Campinas, SP - Brazil. FAU - Modolo, Rodrigo AU - Modolo R AD - Universidade Estadual de Campinas (UNICAMP), Campinas, SP - Brazil. FAU - Moreno, Heitor AU - Moreno H AD - Universidade Estadual de Campinas (UNICAMP), Campinas, SP - Brazil. LA - eng LA - por PT - Journal Article PT - Observational Study DEP - 20170330 PL - Brazil TA - Arq Bras Cardiol JT - Arquivos brasileiros de cardiologia JID - 0421031 RN - 0 (Chemokine CCL2) SB - IM MH - Aged MH - Blood Pressure Monitoring, Ambulatory MH - Chemokine CCL2/*analysis MH - Cross-Sectional Studies MH - Female MH - Humans MH - Hypertension/*physiopathology MH - Hypertrophy, Left Ventricular/*physiopathology MH - Male MH - Middle Aged MH - Severity of Illness Index MH - Ventricular Remodeling/*physiology PMC - PMC5421472 COIS- Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. EDAT- 2017/04/06 06:00 MHDA- 2017/09/07 06:00 PMCR- 2017/04/01 CRDT- 2017/04/06 06:00 PHST- 2016/08/24 00:00 [received] PHST- 2016/12/13 00:00 [accepted] PHST- 2017/04/06 06:00 [pubmed] PHST- 2017/09/07 06:00 [medline] PHST- 2017/04/06 06:00 [entrez] PHST- 2017/04/01 00:00 [pmc-release] AID - S0066-782X2017005005104 [pii] AID - 10.5935/abc.20170033 [doi] PST - ppublish SO - Arq Bras Cardiol. 2017 Apr;108(4):331-338. doi: 10.5935/abc.20170033. Epub 2017 Mar 30.