PMID- 28380482
OWN - NLM
STAT- MEDLINE
DCOM- 20170829
LR  - 20170829
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 172
IP  - 3
DP  - 2017
TI  - Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features.
PG  - 150-160
LID - 10.1159/000458151 [doi]
AB  - BACKGROUND: Identification of asthma phenotypes enables a better understanding 
      and management of this heterogeneous disease. Studies have reported associations 
      between human leukocyte antigens (HLA) and asthma in different populations, but 
      the results have been inconclusive and they have rarely considered the distinct 
      disease phenotypes. Our objective was to characterize allergic and nonallergic 
      asthma phenotypes and evaluate possible associations with the HLA system. 
      METHODS: A total of 109 patients with asthma were prospectively followed during 2 
      years. They were divided into 2 groups, i.e., allergic and nonallergic asthma, 
      according to their clinical history and skin prick test and serum-specific 
      immunoglobulin E (IgE) results. The control group comprised 297 deceased donors 
      of solid organs. Patients' features and HLA class I and II genotypes were 
      assessed and compared. RESULTS: This study showed different features between 
      asthma phenotypes. Nonallergic patients were older at the onset of asthma 
      symptoms and had a higher rate of intolerance to nonsteroidal anti-inflammatory 
      drugs. Allergic patients had higher total serum IgE levels, reported atopic 
      dermatitis and rhinoconjunctivitis more frequently, and, unexpectedly, had a 
      greater disease severity. New associations between the HLA genotypes and allergic 
      and nonallergic asthma were identified. The HLA-B*42, HLA-C*17, HLA-DPA1*03, and 
      HLA-DPB1*105 genotypes were associated with allergic asthma and the HLA-B*48 
      genotype with the nonallergic phenotype. The presence of the haplotype 
      HLA-DPA1*03 DQA*05 was associated with allergic asthma, and the presence of 
      HLA-DPA1*03 and the absence of HLA-DQA*05 with nonallergic asthma. CONCLUSIONS: 
      Allergic and nonallergic asthma have distinct phenotypic and genotypic features. 
      New associations between asthma phenotypes and HLA class I and II were 
      identified.
CI  - (c) 2017 S. Karger AG, Basel.
FAU - Takejima, Priscila
AU  - Takejima P
AD  - Clinical Immunology and Allergy Division, University of Sao Paulo School of 
      Medicine, Sao Paulo, Brazil.
FAU - Agondi, Rosana Camara
AU  - Agondi RC
FAU - Rodrigues, Helcio
AU  - Rodrigues H
FAU - Aun, Marcelo Vivolo
AU  - Aun MV
FAU - Kalil, Jorge
AU  - Kalil J
FAU - Giavina-Bianchi, Pedro
AU  - Giavina-Bianchi P
LA  - eng
PT  - Journal Article
DEP - 20170406
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (HLA Antigens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Anti-Inflammatory Agents, Non-Steroidal/adverse effects
MH  - Asthma/blood/*genetics/immunology
MH  - Brazil
MH  - Cohort Studies
MH  - Female
MH  - Genotype
MH  - HLA Antigens/*genetics/immunology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Middle Aged
MH  - Phenotype
OTO - NOTNLM
OT  - Allergic asthma
OT  - Asthma
OT  - Human leukocyte antigens
OT  - Nonatopic
EDAT- 2017/04/06 06:00
MHDA- 2017/08/30 06:00
CRDT- 2017/04/06 06:00
PHST- 2016/08/04 00:00 [received]
PHST- 2017/01/26 00:00 [accepted]
PHST- 2017/04/06 06:00 [pubmed]
PHST- 2017/08/30 06:00 [medline]
PHST- 2017/04/06 06:00 [entrez]
AID - 000458151 [pii]
AID - 10.1159/000458151 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2017;172(3):150-160. doi: 10.1159/000458151. Epub 2017 
      Apr 6.