PMID- 28381508
OWN - NLM
STAT- MEDLINE
DCOM- 20170526
LR  - 20220419
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 88
IP  - 18
DP  - 2017 May 2
TI  - Clinical manifestations of the anti-IgLON5 disease.
PG  - 1736-1743
LID - 10.1212/WNL.0000000000003887 [doi]
AB  - OBJECTIVE: To report the presentation, main syndromes, human leukocyte antigen 
      (HLA) association, and immunoglobulin G (IgG) subclass in the anti-IgLON5 
      disease: a disorder with parasomnias, sleep apnea, and IgLON5 antibodies. 
      METHODS: This was a retrospective clinical analysis of 22 patients. The IgG 
      subclass was determined using reported techniques. RESULTS: Patients' median age 
      was 64 years (range 46-83). Symptoms that led to initial consultation included 
      sleep problems (8 patients; 36%), gait abnormalities (8; 36%), bulbar dysfunction 
      (3; 14%), chorea (2; 9%), and cognitive decline (1; 5%). By the time of diagnosis 
      of the disorder, 4 syndromes were identified: (1) a sleep disorder with 
      parasomnia and sleep breathing difficulty in 8 (36%) patients; (2) a bulbar 
      syndrome including dysphagia, sialorrhea, stridor, or acute respiratory 
      insufficiency in 6 (27%); (3) a syndrome resembling progressive supranuclear 
      palsy (PSP-like) in 5 (23%); and (4) cognitive decline with or without chorea in 
      3 (14%). All patients eventually developed parasomnia, sleep apnea, insomnia, or 
      excessive daytime sleepiness. HLA-DRB1*10:01 and HLA-DQB1*05:01 were positive in 
      13/15 (87%) patients; the DRB1*10:01 allele was 36 times more prevalent than in 
      the general population. Among 16 patients with paired serum and CSF samples, 14 
      had IgLON5 antibodies in both, and 2 only in serum (both had a PSP-like 
      syndrome). Twenty of 21 patients had IgG1 and IgG4 antibodies; the latter 
      predominated in 16. CONCLUSIONS: Patients with IgLON5 antibodies develop a 
      characteristic sleep disorder preceded or accompanied by bulbar symptoms, gait 
      abnormalities, oculomotor problems, and, less frequently, cognitive decline. IgG4 
      subclass antibodies predominate over IgG1; we confirm a strong association with 
      the HLA-DRB1*10:01 allele.
CI  - (c) 2017 American Academy of Neurology.
FAU - Gaig, Carles
AU  - Gaig C
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Graus, Francesc
AU  - Graus F
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain. fgraus@clinic.ub.es.
FAU - Compta, Yarko
AU  - Compta Y
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Hogl, Birgit
AU  - Hogl B
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Bataller, Luis
AU  - Bataller L
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Bruggemann, Norbert
AU  - Bruggemann N
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Giordana, Caroline
AU  - Giordana C
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Heidbreder, Anna
AU  - Heidbreder A
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Kotschet, Katya
AU  - Kotschet K
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Lewerenz, Jan
AU  - Lewerenz J
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Macher, Stefan
AU  - Macher S
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Marti, Maria J
AU  - Marti MJ
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Montojo, Teresa
AU  - Montojo T
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Perez-Perez, Jesus
AU  - Perez-Perez J
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Puertas, Inmaculada
AU  - Puertas I
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Seitz, Caspar
AU  - Seitz C
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Simabukuro, Mateus
AU  - Simabukuro M
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Tellez, Nieves
AU  - Tellez N
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Wandinger, Klaus-Peter
AU  - Wandinger KP
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Iranzo, Alex
AU  - Iranzo A
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Ercilla, Guadalupe
AU  - Ercilla G
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Sabater, Lidia
AU  - Sabater L
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Santamaria, Joan
AU  - Santamaria J
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
FAU - Dalmau, Josep
AU  - Dalmau J
AD  - From the Neuroimmunology Program (C. Gaig, F.G., A.I., L.S., J.S., J.D.), 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS); Department of 
      Neurology (C. Gaig, F.G., Y.C., M.J.M., A.I., J.S.), Multidisciplinary Sleep 
      Disorders Unit (C. Gaig, A.I., J.S.), Parkinson's Disease & Movement Disorders 
      Unit (Y.C., M.J.M.), and Department of Immunology (G.E.), Hospital Clinic, 
      Barcelona, Spain; Department of Neurology (B.H.), Medical University of 
      Innsbruck, Austria; Department of Neurology (L.B.), Hospital Universitari i 
      Politecnic La Fe; Centro de Investigacion Biomedica en Red de Enfermedades Raras 
      (CIBERER) (L.B., L.S., J.D.), Valencia, Spain; Department of Neurology and 
      Institute of Neurogenetics (N.P., K.-P.W.), University of Lubeck, Germany; 
      Department of Movement Disorders and Neurology (C. Giordana), Centre Hospitalier 
      Universitaire Nice, France; Department of Neurology (A.H.), Division of Sleep 
      Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany; 
      Clinical Neurosciences (K.K.), St Vincent's Hospital, Melbourne, Australia; 
      Department of Neurology (J.L.), Ulm University, Germany; Department of Neurology 
      (S.M.), Medical University of Vienna, Austria; Department of Neurology (T.M.), 
      Centre Hospitalier de Luxembourg; Department of Neurology (J.P.-P.), Hospital de 
      la Santa Creu i Sant Pau, Barcelona; Department of Neurology (I.P.), Hospital La 
      Paz, Madrid, Spain; Department of Neurology (C.S.), University Medical Center of 
      the Johannes Gutenberg University Mainz, Germany; Neurology Division (M.S.), 
      Hospital das Clinicas, Sao Paulo University, Brazil; Department of Neurology 
      (N.T.), Hospital Clinico Universitario, Valladolid, Spain; Institute of Clinical 
      Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Lubeck, Germany; 
      Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; and 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA) (J.D.), Barcelona, 
      Spain.
LA  - eng
GR  - R01 NS077851/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20170405
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cell Adhesion Molecules, Neuronal)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (IgLON5 protein, human)
RN  - 0 (Immunoglobulin G)
RN  - 0 (prolactin-binding protein)
SB  - IM
CIN - Neurology. 2017 May 2;88(18):1688-1690. PMID: 28381512
MH  - Aged
MH  - Aged, 80 and over
MH  - Autoantibodies/metabolism
MH  - Autoimmune Diseases/*diagnosis/*physiopathology/therapy
MH  - Biomarkers/blood/cerebrospinal fluid
MH  - Brain/diagnostic imaging
MH  - Carrier Proteins/metabolism
MH  - Cell Adhesion Molecules, Neuronal/*immunology
MH  - HLA-DRB1 Chains/metabolism
MH  - Humans
MH  - Immunoglobulin G/metabolism
MH  - Immunotherapy
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Sleep Wake Disorders/*diagnosis/*physiopathology/therapy
PMC - PMC5409845
EDAT- 2017/04/07 06:00
MHDA- 2017/05/27 06:00
PMCR- 2018/05/02
CRDT- 2017/04/07 06:00
PHST- 2016/08/12 00:00 [received]
PHST- 2017/01/17 00:00 [accepted]
PHST- 2017/04/07 06:00 [pubmed]
PHST- 2017/05/27 06:00 [medline]
PHST- 2017/04/07 06:00 [entrez]
PHST- 2018/05/02 00:00 [pmc-release]
AID - WNL.0000000000003887 [pii]
AID - NEUROLOGY2016763748 [pii]
AID - 10.1212/WNL.0000000000003887 [doi]
PST - ppublish
SO  - Neurology. 2017 May 2;88(18):1736-1743. doi: 10.1212/WNL.0000000000003887. Epub 
      2017 Apr 5.