PMID- 28381513
OWN - NLM
STAT- MEDLINE
DCOM- 20170526
LR  - 20220409
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 88
IP  - 18
DP  - 2017 May 2
TI  - Outcome of intracerebral hemorrhage associated with different oral 
      anticoagulants.
PG  - 1693-1700
LID - 10.1212/WNL.0000000000003886 [doi]
AB  - OBJECTIVE: In an international collaborative multicenter pooled analysis, we 
      compared mortality, functional outcome, intracerebral hemorrhage (ICH) volume, 
      and hematoma expansion (HE) between non-vitamin K antagonist oral 
      anticoagulation-related ICH (NOAC-ICH) and vitamin K antagonist-associated ICH 
      (VKA-ICH). METHODS: We compared all-cause mortality within 90 days for NOAC-ICH 
      and VKA-ICH using a Cox proportional hazards model adjusted for age; sex; 
      baseline Glasgow Coma Scale score, ICH location, and log volume; intraventricular 
      hemorrhage volume; and intracranial surgery. We addressed heterogeneity using a 
      shared frailty term. Good functional outcome was defined as discharge modified 
      Rankin Scale score </=2 and investigated in multivariable logistic regression. ICH 
      volume was measured by ABC/2 or a semiautomated planimetric method. HE was 
      defined as an ICH volume increase >33% or >6 mL from baseline within 72 hours. 
      RESULTS: We included 500 patients (97 NOAC-ICH and 403 VKA-ICH). Median baseline 
      ICH volume was 14.4 mL (interquartile range [IQR] 3.6-38.4) for NOAC-ICH vs 10.6 
      mL (IQR 4.0-27.9) for VKA-ICH (p = 0.78). We did not find any difference between 
      NOAC-ICH and VKA-ICH for all-cause mortality within 90 days (33% for NOAC-ICH vs 
      31% for VKA-ICH [p = 0.64]; adjusted Cox hazard ratio (for NOAC-ICH vs VKA-ICH) 
      0.93 [95% confidence interval (CI) 0.52-1.64] [p = 0.79]), the rate of HE 
      (NOAC-ICH n = 29/48 [40%] vs VKA-ICH n = 93/140 [34%] [p = 0.45]), or functional 
      outcome at hospital discharge (NOAC-ICH vs VKA-ICH odds ratio 0.47; 95% CI 
      0.18-1.19 [p = 0.11]). CONCLUSIONS: In our international collaborative 
      multicenter pooled analysis, baseline ICH volume, hematoma expansion, 90-day 
      mortality, and functional outcome were similar following NOAC-ICH and VKA-ICH.
CI  - Copyright (c) 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on 
      behalf of the American Academy of Neurology.
FAU - Wilson, Duncan
AU  - Wilson D
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Seiffge, David J
AU  - Seiffge DJ
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Traenka, Christopher
AU  - Traenka C
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Basir, Ghazala
AU  - Basir G
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Purrucker, Jan C
AU  - Purrucker JC
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Rizos, Timolaos
AU  - Rizos T
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Sobowale, Oluwaseun A
AU  - Sobowale OA
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Sallinen, Hanne
AU  - Sallinen H
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Yeh, Shin-Joe
AU  - Yeh SJ
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Wu, Teddy Y
AU  - Wu TY
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Ferrigno, Marc
AU  - Ferrigno M
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Houben, Rik
AU  - Houben R
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Schreuder, Floris H B M
AU  - Schreuder FHBM
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Perry, Luke A
AU  - Perry LA
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Tanaka, Jun
AU  - Tanaka J
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Boulanger, Marion
AU  - Boulanger M
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Al-Shahi Salman, Rustam
AU  - Al-Shahi Salman R
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Jager, Hans R
AU  - Jager HR
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Ambler, Gareth
AU  - Ambler G
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Shakeshaft, Clare
AU  - Shakeshaft C
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Yakushiji, Yusuke
AU  - Yakushiji Y
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Choi, Philip M C
AU  - Choi PMC
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Staals, Julie
AU  - Staals J
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Cordonnier, Charlotte
AU  - Cordonnier C
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Jeng, Jiann-Shing
AU  - Jeng JS
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Veltkamp, Roland
AU  - Veltkamp R
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Dowlatshahi, Dar
AU  - Dowlatshahi D
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Engelter, Stefan T
AU  - Engelter ST
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Parry-Jones, Adrian R
AU  - Parry-Jones AR
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Meretoja, Atte
AU  - Meretoja A
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland.
FAU - Werring, David J
AU  - Werring DJ
AD  - From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological 
      Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute 
      of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; 
      Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, 
      University of Basel, Switzerland; Ottawa Hospital Research Institute and 
      University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., 
      T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health 
      Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; 
      Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; 
      Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of 
      Neurology, National Taiwan University Hospital, Taipei; Department of Medicine 
      and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of 
      Melbourne, Parkville, Australia; U1171-Degenerative & Vascular Cognitive 
      Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of 
      Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the 
      Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, 
      Melbourne, Australia; Division of Neurology, Department of Internal Medicine 
      (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical 
      Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of 
      Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, 
      Division of Brain Sciences (R.V.), Imperial College London, UK; and 
      Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for 
      Medicine of Aging, Felix Platter Hospital, Switzerland. d.werring@ucl.ac.uk.
CN  - And the CROMIS-2 collaborators
LA  - eng
GR  - G1002605/MRC_/Medical Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
DEP - 20170405
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Anticoagulants)
RN  - 12001-79-5 (Vitamin K)
SB  - IM
CIN - Neurology. 2017 May 2;88(18):1686-1687. PMID: 28381509
EIN - Neurology. 2018 Jun 5;90(23):1084. PMID: 29866942
MH  - Administration, Oral
MH  - Anticoagulants/*administration & dosage
MH  - Cerebral Hemorrhage/*drug therapy/*mortality/pathology/surgery
MH  - Female
MH  - Glasgow Coma Scale
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Multivariate Analysis
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Registries
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Treatment Outcome
MH  - Vitamin K/antagonists & inhibitors
PMC - PMC5409844
FIR - Shaw, Louise
IR  - Shaw L
FIR - Sword, Jane
IR  - Sword J
FIR - Mohd, Azlisham
IR  - Mohd A
FIR - Sharma, Pankaj
IR  - Sharma P
FIR - Kelly, Deborah
IR  - Kelly D
FIR - Harrington, Frances
IR  - Harrington F
FIR - Sprigg, Nikola
IR  - Sprigg N
FIR - Randall, Marc
IR  - Randall M
FIR - Smith, Matthew
IR  - Smith M
FIR - Mahawish, Karim
IR  - Mahawish K
FIR - Elmarim, Abduelbaset
IR  - Elmarim A
FIR - Esisi, Bernard
IR  - Esisi B
FIR - Cullen, Claire
IR  - Cullen C
FIR - Nallasivam, Arumug
IR  - Nallasivam A
FIR - Price, Christopher
IR  - Price C
FIR - Barry, Adrian
IR  - Barry A
FIR - Roffe, Christine
IR  - Roffe C
FIR - Coyle, John
IR  - Coyle J
FIR - Hassan, Ahamad
IR  - Hassan A
FIR - Lovelock, Caroline
IR  - Lovelock C
FIR - Birns, Jonathan
IR  - Birns J
FIR - Cohen, David
IR  - Cohen D
FIR - Sekaran, L
IR  - Sekaran L
FIR - Parry-Jones, Adrian
IR  - Parry-Jones A
FIR - Parry, Anthea
IR  - Parry A
FIR - Hargroves, David
IR  - Hargroves D
FIR - Proschel, Harald
IR  - Proschel H
FIR - Datta, Prabel
IR  - Datta P
FIR - Darawil, Khaled
IR  - Darawil K
FIR - Manoj, Aravindakshan
IR  - Manoj A
FIR - Burn, Mathew
IR  - Burn M
FIR - Patterson, Chris
IR  - Patterson C
FIR - Giallombardo, Elio
IR  - Giallombardo E
FIR - Smyth, Nigel
IR  - Smyth N
FIR - Mansoor, Syed
IR  - Mansoor S
FIR - Anwar, Ijaz
IR  - Anwar I
FIR - Marsh, Rachel
IR  - Marsh R
FIR - Ispoglou, Sissi
IR  - Ispoglou S
FIR - Chadha, Dinesh
IR  - Chadha D
FIR - Prabhakaran, Mathuri
IR  - Prabhakaran M
FIR - Meenakishundaram, Sanjeevikumar
IR  - Meenakishundaram S
FIR - O'Connell, Janice
IR  - O'Connell J
FIR - Scott, Jon
IR  - Scott J
FIR - Krishnamurthy, Vinodh
IR  - Krishnamurthy V
FIR - Aghoram, Prasanna
IR  - Aghoram P
FIR - McCormick, Michael
IR  - McCormick M
FIR - O'Mahony, Paul
IR  - O'Mahony P
FIR - Cooper, Martin
IR  - Cooper M
FIR - Choy, Lillian
IR  - Choy L
FIR - Wilkinson, Peter
IR  - Wilkinson P
FIR - Leach, Simon
IR  - Leach S
FIR - Caine, Sarah
IR  - Caine S
FIR - Burger, Ilse
IR  - Burger I
FIR - Gunathilagan, Gunaratam
IR  - Gunathilagan G
FIR - Guyler, Paul
IR  - Guyler P
FIR - Emsley, Hedley
IR  - Emsley H
FIR - Davis, Michelle
IR  - Davis M
FIR - Manawadu, Dulka
IR  - Manawadu D
FIR - Pasco, Kath
IR  - Pasco K
FIR - Mamun, Maam
IR  - Mamun M
FIR - Luder, Robert
IR  - Luder R
FIR - Sajid, Mahmud
IR  - Sajid M
FIR - Anwar, Ijaz
IR  - Anwar I
FIR - Okwera, James
IR  - Okwera J
FIR - Staals, Julie
IR  - Staals J
FIR - Warburton, Elizabeth
IR  - Warburton E
FIR - Saastamoinen, Kari
IR  - Saastamoinen K
FIR - England, Timothy
IR  - England T
FIR - Putterill, Janet
IR  - Putterill J
FIR - Flossman, Enrico
IR  - Flossman E
FIR - Power, Michael
IR  - Power M
FIR - Dani, Krishna
IR  - Dani K
FIR - Mangion, David
IR  - Mangion D
FIR - Corrigan, John
IR  - Corrigan J
FIR - Suman, Appu
IR  - Suman A
FIR - Corrigan, John
IR  - Corrigan J
FIR - Lawrence, Enas
IR  - Lawrence E
FIR - Vahidassr, Djamil
IR  - Vahidassr D
EDAT- 2017/04/07 06:00
MHDA- 2017/05/27 06:00
PMCR- 2017/05/02
CRDT- 2017/04/07 06:00
PHST- 2016/07/10 00:00 [received]
PHST- 2017/01/18 00:00 [accepted]
PHST- 2017/04/07 06:00 [pubmed]
PHST- 2017/05/27 06:00 [medline]
PHST- 2017/04/07 06:00 [entrez]
PHST- 2017/05/02 00:00 [pmc-release]
AID - WNL.0000000000003886 [pii]
AID - NEUROLOGY2016757070 [pii]
AID - 10.1212/WNL.0000000000003886 [doi]
PST - ppublish
SO  - Neurology. 2017 May 2;88(18):1693-1700. doi: 10.1212/WNL.0000000000003886. Epub 
      2017 Apr 5.