PMID- 28382274
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2233-601X (Print)
IS  - 2093-6516 (Electronic)
IS  - 2233-601X (Linking)
VI  - 50
IP  - 2
DP  - 2017 Apr
TI  - Circulating Aneuploid Cells Detected in the Blood of Patients with Infectious 
      Lung Diseases.
PG  - 126-129
LID - 10.5090/kjtcs.2017.50.2.126 [doi]
AB  - The identification of circulating tumor cells (CTCs) is clinically important for 
      diagnosing cancer. We have previously developed a size-based filtration platform 
      followed by epithelial cell adhesion molecule immunofluorescence staining for 
      detecting CTCs. To characterize CTCs independently of cell surface protein 
      expression, we incorporated a chromosomal fluorescence in situ hybridization 
      (FISH) assay to detect abnormal copy numbers of chromosomes in cells collected 
      from peripheral blood samples by the size-based filtration platform. Aneuploid 
      cells were detected in the peripheral blood of patients with lung cancer. 
      Unexpectedly, aneuploid cells were also detected in the control group, which 
      consisted of peripheral blood samples from patients with benign lung diseases, 
      such as empyema necessitatis and non-tuberculous mycobacterial lung disease. 
      These findings suggest that chromosomal abnormalities are observed not only in 
      tumor cells, but also in benign infectious diseases. Thus, our findings present 
      new considerations and bring into light the possibility of false positives when 
      using FISH for cancer diagnosis.
FAU - Kim, Hongsun
AU  - Kim H
AD  - Department of Thoracic and Cardiovascular Surgery, Sungkyunkwan University School 
      of Medicine.
FAU - Cho, Jong Ho
AU  - Cho JH
AD  - Department of Thoracic and Cardiovascular Surgery, Sungkyunkwan University School 
      of Medicine.
FAU - Sonn, Chung-Hee
AU  - Sonn CH
AD  - Samsung Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan 
      University School of Medicine.
FAU - Kim, Jae-Won
AU  - Kim JW
AD  - Samsung Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan 
      University School of Medicine.
FAU - Choi, Yul
AU  - Choi Y
AD  - Department of Thoracic and Cardiovascular Surgery, Sungkyunkwan University School 
      of Medicine.
FAU - Lee, Jinseon
AU  - Lee J
AD  - Samsung Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan 
      University School of Medicine.
FAU - Kim, Jhingook
AU  - Kim J
AD  - Department of Thoracic and Cardiovascular Surgery, Sungkyunkwan University School 
      of Medicine; Samsung Biomedical Research Institute, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine.
LA  - eng
PT  - Case Reports
DEP - 20170405
PL  - Korea (South)
TA  - Korean J Thorac Cardiovasc Surg
JT  - The Korean journal of thoracic and cardiovascular surgery
JID - 101563922
EIN - Korean J Thorac Cardiovasc Surg. 2017 Jun;50(3):228. PMID: 28593163
PMC - PMC5380208
OTO - NOTNLM
OT  - Circulating neoplastic cells
OT  - Fluorescent in situ hybridization
OT  - Lung neoplasms
EDAT- 2017/04/07 06:00
MHDA- 2017/04/07 06:01
PMCR- 2017/04/01
CRDT- 2017/04/07 06:00
PHST- 2016/07/13 00:00 [received]
PHST- 2016/12/03 00:00 [revised]
PHST- 2016/12/13 00:00 [accepted]
PHST- 2017/04/07 06:00 [entrez]
PHST- 2017/04/07 06:00 [pubmed]
PHST- 2017/04/07 06:01 [medline]
PHST- 2017/04/01 00:00 [pmc-release]
AID - kjtcvs-50-126 [pii]
AID - 10.5090/kjtcs.2017.50.2.126 [doi]
PST - ppublish
SO  - Korean J Thorac Cardiovasc Surg. 2017 Apr;50(2):126-129. doi: 
      10.5090/kjtcs.2017.50.2.126. Epub 2017 Apr 5.