PMID- 28384257
OWN - NLM
STAT- MEDLINE
DCOM- 20170907
LR  - 20240327
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 4
DP  - 2017
TI  - Serum Th1 and Th17 related cytokines and autoantibodies in patients with 
      Posner-Schlossman syndrome.
PG  - e0175519
LID - 10.1371/journal.pone.0175519 [doi]
LID - e0175519
AB  - Posner-Schlossman syndrome (PSS) shares some clinical features with uveitis and 
      open angle glaucoma. Cytokines and autoantibodies have been associated with 
      uveitis and open angle glaucoma. However, the role of serum cytokines and 
      autoantibodies in the pathogenesis of PSS remains unknown. This study aimed to 
      evaluate the associations of type 1 T helper (Th1) and Th17 related cytokines and 
      autoantibodies with PSS. Peripheral blood serum samples were collected from 81 
      patients with PSS and 97 gender- and age-matched healthy blood donors. Th1 and 
      Th17 related cytokines, including interleukin-1beta (IL-1beta), IL-12, tumor necrosis 
      factor-alpha (TNF-alpha), interferon- gamma (IFN-gamma), IL-6 and IL-17, and glucose-6-phosphate 
      isomerase (GPI) were determined by double antibody sandwich ELISA. Anti-nuclear 
      antibody (ANA), anti-keratin antibody (AKA) and anti-neutrophil cytoplasmic 
      antibody (ANCA) were detected by indirect immunofluorescence assay. 
      Anti-cardiolipin antibody (ACA)-IgG, ACA-IgM, ACA-IgA, anti-double stranded DNA 
      (anti-dsDNA) and anti-cyclic citrullinated peptide antibody (anti-CCP) were 
      detected by indirect ELISA. Serum levels of IL-1beta, IL-12 and IL-6 in PSS patients 
      were significantly lower than those in controls (P < 0.003), and these 
      associations survived the Bonferroni correction (Pc < 0.018). There was no 
      significant difference in serum levels of TNF-alpha, IFN-gamma and IL-17 between the PSS 
      and control groups (Pc > 0.12). Positive rate of serum anti-dsDNA in PSS patients 
      was significantly higher than that in the control group (P = 0.002, Pc = 0.018), 
      while positive rates of serum ANA, AKA, ANCA, ACA-IgG, ACA-IgM, ACA-IgA, GPI and 
      anti-CCP in the PSS group were not significantly different from those in the 
      control group (Pc > 0.09). These results suggest that anti-dsDNA may contribute 
      to the pathogenesis of PSS, while Th1 and Th17 related cytokines and other 
      autoantibodies may not be major contributors to PSS.
FAU - Zhao, Jun
AU  - Zhao J
AD  - Shenzhen Key Laboratory of Ophthalmology, Shenzhen Eye Hospital Affiliated to 
      Jinan University, Shenzhen, Guangdong, China.
AD  - School of Ophthalmology & Optometry Affiliated to Shenzhen University, Shenzhen, 
      Guangdong, China.
FAU - Chen, Wenchieh
AU  - Chen W
AD  - Shenzhen Key Laboratory of Ophthalmology, Shenzhen Eye Hospital Affiliated to 
      Jinan University, Shenzhen, Guangdong, China.
FAU - Huang, Xiaosheng
AU  - Huang X
AD  - Shenzhen Key Laboratory of Ophthalmology, Shenzhen Eye Hospital Affiliated to 
      Jinan University, Shenzhen, Guangdong, China.
FAU - Peng, Shiming
AU  - Peng S
AD  - Shenzhen Key Laboratory of Ophthalmology, Shenzhen Eye Hospital Affiliated to 
      Jinan University, Shenzhen, Guangdong, China.
FAU - Zhu, Tianhui
AU  - Zhu T
AD  - Shenzhen Key Laboratory of Ophthalmology, Shenzhen Eye Hospital Affiliated to 
      Jinan University, Shenzhen, Guangdong, China.
FAU - Deng, Zhihui
AU  - Deng Z
AD  - Immunogenetics Laboratory, Shenzhen Blood Center, Shenzhen, Guangdong, China.
FAU - Liang, Ping
AU  - Liang P
AD  - School of Ophthalmology & Optometry Affiliated to Shenzhen University, Shenzhen, 
      Guangdong, China.
FAU - Chang, Hui
AU  - Chang H
AD  - Shenzhen Key Laboratory of Ophthalmology, Shenzhen Eye Hospital Affiliated to 
      Jinan University, Shenzhen, Guangdong, China.
FAU - Fan, Bao Jian
AU  - Fan BJ
AUID- ORCID: 0000-0002-6851-2737
AD  - Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear 
      Infirmary, Boston, Massachusetts, United States of America.
LA  - eng
PT  - Journal Article
DEP - 20170406
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Autoantibodies)
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - Autoantibodies/*blood
MH  - Case-Control Studies
MH  - Cytokines/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glaucoma, Open-Angle/*blood/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Syndrome
MH  - Th1 Cells/*immunology
MH  - Th17 Cells/*immunology
MH  - Uveitis/*blood/immunology
PMC - PMC5383301
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/04/07 06:00
MHDA- 2017/09/08 06:00
PMCR- 2017/04/06
CRDT- 2017/04/07 06:00
PHST- 2016/12/29 00:00 [received]
PHST- 2017/03/27 00:00 [accepted]
PHST- 2017/04/07 06:00 [entrez]
PHST- 2017/04/07 06:00 [pubmed]
PHST- 2017/09/08 06:00 [medline]
PHST- 2017/04/06 00:00 [pmc-release]
AID - PONE-D-16-51431 [pii]
AID - 10.1371/journal.pone.0175519 [doi]
PST - epublish
SO  - PLoS One. 2017 Apr 6;12(4):e0175519. doi: 10.1371/journal.pone.0175519. 
      eCollection 2017.