PMID- 28384399 OWN - NLM STAT- MEDLINE DCOM- 20180314 LR - 20200108 IS - 1934-8258 (Electronic) IS - 1934-8258 (Linking) VI - 93 DP - 2017 Apr 6 TI - Molecular Analysis of Genetic Markers for Non-Hodgkin Lymphomas. PG - 10.14.1-10.14.29 LID - 10.1002/cphg.37 [doi] AB - Molecular analysis complements the clinical and histopathologic tools used to diagnose and subclassify hematologic malignancies. The presence of clonal antigen-receptor gene rearrangements can help to confirm the diagnosis of a B or T cell lymphoma and can serve as a fingerprint of that neoplasm to be used in identifying concurrent disease at disparate sites or recurrence at future time points. Certain lymphoid malignancies harbor a characteristic chromosomal translocation, a finding that may have significant implications for an individual's prognosis or response to therapy. The polymerase chain reaction (PCR) is typically used to detect antigen-receptor gene rearrangements as well as specific translocations that can be supplemented by fluorescence in situ hybridization (FISH) and karyotype analysis. (c) 2017 by John Wiley & Sons, Inc. CI - Copyright (c) 2017 John Wiley & Sons, Inc. FAU - Sholl, Lynette M AU - Sholl LM AD - Brigham and Women's Hospital, Boston, Massachusetts. FAU - Longtine, Janina AU - Longtine J AD - Yale New Haven Hospital, New Haven, Connecticut. FAU - Kuo, Frank C AU - Kuo FC AD - Brigham and Women's Hospital, Boston, Massachusetts. LA - eng PT - Journal Article DEP - 20170406 PL - United States TA - Curr Protoc Hum Genet JT - Current protocols in human genetics JID - 101287858 RN - 0 (Genetic Markers) SB - IM MH - DNA Mutational Analysis/*methods MH - Gene Rearrangement/genetics MH - Genetic Markers/*genetics MH - Humans MH - In Situ Hybridization, Fluorescence MH - Lymphoma, Non-Hodgkin/*genetics MH - Polymerase Chain Reaction MH - Translocation, Genetic/genetics OTO - NOTNLM OT - antigen receptor gene rearrangements OT - lymphoma OT - translocations EDAT- 2017/04/07 06:00 MHDA- 2018/03/15 06:00 CRDT- 2017/04/07 06:00 PHST- 2017/04/07 06:00 [entrez] PHST- 2017/04/07 06:00 [pubmed] PHST- 2018/03/15 06:00 [medline] AID - 10.1002/cphg.37 [doi] PST - epublish SO - Curr Protoc Hum Genet. 2017 Apr 6;93:10.14.1-10.14.29. doi: 10.1002/cphg.37.