PMID- 28384582
OWN - NLM
STAT- MEDLINE
DCOM- 20180730
LR  - 20181202
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 595
DP  - 2017 Oct 1
TI  - Dioxins/furans and PCBs in Canadian human milk: 2008-2011.
PG  - 269-278
LID - S0048-9697(17)30678-2 [pii]
LID - 10.1016/j.scitotenv.2017.03.157 [doi]
AB  - Human milk was collected between 2008 and 2011 as part of the Maternal - Infant 
      Research on Environmental Chemicals (MIREC) study that was initiated to establish 
      Canadian national estimates of maternal and infant exposure to a broad suite of 
      environmental contaminants (e.g., persistent organic pollutants [POPs], trace 
      elements, phthalates, etc.). Among the 1017 human milk samples collected, 298 
      were analysed for polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans 
      (PCDFs) and polychlorinated biphenyls (PCBs). World Health Organization (WHO) 
      toxic equivalency concentrations (WHO TEQ(2005)) for PCDD/F+dioxin-like (DL) PCB 
      ranged from 2.2pg TEQ(2005) g(-1) lipid to 27pg TEQ(2005) g(-1) lipid. The 
      relative contribution of PCDDs to the overall WHO TEQ(2005) (PCDD/F+DL PCB) has 
      decreased from earlier investigations into POP levels in Canadian human milk. 
      Significantly higher PCB concentrations were observed in milk from women born in 
      Europe relative to those born in Canada (p<0.001), in contrast to results for the 
      PCDD/Fs (p=0.496). Age was found to significantly impact milk  summation operatorPCB concentrations 
      (p=0.018), with elevated concentrations observed in milk from women >30years 
      relative to those <30years of age. While this trend was also observed for the 
      PCDD/Fs, this relationship was impacted by parity. WHO TEQ(2005) concentrations 
      were significantly higher in milk from primiparous women (p=0.019) and those 
      >30years relative to those <30years of age (p<0.001). No significant differences 
      were associated with education level or pre-pregnancy body mass index. PCB and 
      PCDD/F concentrations have continued to decline in Canadian human milk since the 
      last sampling of human milk was performed.
CI  - Crown Copyright (c) 2017. Published by Elsevier B.V. All rights reserved.
FAU - Rawn, Dorothea F K
AU  - Rawn DFK
AD  - Food Research Division, Bureau of Chemical Safety, Health Products and Food 
      Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick 
      Banting Driveway, 2203C, Tunney's Pasture, Ottawa, ON K1A 0K9, Canada. Electronic 
      address: thea.rawn@hc-sc.gc.ca.
FAU - Sadler, Amy R
AU  - Sadler AR
AD  - Food Research Division, Bureau of Chemical Safety, Health Products and Food 
      Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick 
      Banting Driveway, 2203C, Tunney's Pasture, Ottawa, ON K1A 0K9, Canada.
FAU - Casey, Valerie A
AU  - Casey VA
AD  - Food Research Division, Bureau of Chemical Safety, Health Products and Food 
      Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick 
      Banting Driveway, 2203C, Tunney's Pasture, Ottawa, ON K1A 0K9, Canada.
FAU - Breton, Francois
AU  - Breton F
AD  - Food Research Division, Bureau of Chemical Safety, Health Products and Food 
      Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick 
      Banting Driveway, 2203C, Tunney's Pasture, Ottawa, ON K1A 0K9, Canada.
FAU - Sun, Wing-Fung
AU  - Sun WF
AD  - Food Research Division, Bureau of Chemical Safety, Health Products and Food 
      Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick 
      Banting Driveway, 2203C, Tunney's Pasture, Ottawa, ON K1A 0K9, Canada.
FAU - Arbuckle, Tye E
AU  - Arbuckle TE
AD  - Environmental Health Science and Research Bureau, Environmental and Radiation 
      Health Sciences Directorate, Healthy Environments and Consumer Safety Branch, 
      Health Canada, 50 Colombine Driveway, 0801A, Ottawa, ON K1A 0K9, Canada.
FAU - Fraser, William D
AU  - Fraser WD
AD  - CHU Sainte-Justine, Centre de recherche, Universite de Montreal, Montreal, QC, 
      Canada.
LA  - eng
PT  - Journal Article
DEP - 20170404
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Benzofurans)
RN  - 0 (Dibenzofurans, Polychlorinated)
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Furans)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Benzofurans
MH  - Canada
MH  - Dibenzofurans, Polychlorinated
MH  - Dioxins/*analysis
MH  - Environmental Pollutants/*analysis
MH  - Europe
MH  - Female
MH  - Furans/*analysis
MH  - Humans
MH  - Milk, Human/*chemistry
MH  - Polychlorinated Biphenyls/*analysis
MH  - Polychlorinated Dibenzodioxins
MH  - Pregnancy
OTO - NOTNLM
OT  - Dioxins/furans
OT  - Human milk
OT  - MIREC
OT  - PCBs
OT  - POPs
EDAT- 2017/04/07 06:00
MHDA- 2018/07/31 06:00
CRDT- 2017/04/07 06:00
PHST- 2016/12/15 00:00 [received]
PHST- 2017/02/24 00:00 [revised]
PHST- 2017/03/17 00:00 [accepted]
PHST- 2017/04/07 06:00 [pubmed]
PHST- 2018/07/31 06:00 [medline]
PHST- 2017/04/07 06:00 [entrez]
AID - S0048-9697(17)30678-2 [pii]
AID - 10.1016/j.scitotenv.2017.03.157 [doi]
PST - ppublish
SO  - Sci Total Environ. 2017 Oct 1;595:269-278. doi: 10.1016/j.scitotenv.2017.03.157. 
      Epub 2017 Apr 4.