PMID- 28385062
OWN - NLM
STAT- MEDLINE
DCOM- 20180622
LR  - 20190202
IS  - 1557-9042 (Electronic)
IS  - 0897-7151 (Linking)
VI  - 34
IP  - 21
DP  - 2017 Nov 1
TI  - Diffusion Tensor Imaging Parameter Obtained during Acute Blunt Cervical Spinal 
      Cord Injury in Predicting Long-Term Outcome.
PG  - 2964-2971
LID - 10.1089/neu.2016.4901 [doi]
AB  - There are no reliable neuroimaging biomarkers to predict long-term outcome after 
      spinal cord injury. This prospective longitudinal study evaluates diffusion 
      tensor imaging (DTI) in predicting long-term outcome after cervical spinal cord 
      injury (CSCI). We investigate the admission DTI parameters measured in 30 
      patients with CSCI, with 16 of them followed up to one year, and 15 volunteers 
      serving as controls. All magnetic resonance imaging examinations were performed 
      within 24 h of injury. The DTI parameters were measured in patients and controls, 
      avoiding areas of hemorrhage in patients and at corresponding upper/middle/lower 
      regions of the spinal cord in controls. Stepwise regression analysis was 
      performed to find relevant parameters (normalized DTI values, age, sex, 
      hemorrhagic contusion [HC or non-HC]) that correlated with two primary outcome 
      measures: patient International Standards for Neurological Classification of 
      Spinal Cord Injury (ISNCSCI) motor and Spinal Cord Independence Measure (SCIM 
      III) scores at one year. Among all DTI measures, axial diffusivity (AD) most 
      strongly correlated with both motor (r(2) = 0.76, p < 0.01) and SCIM III scores 
      (r(2) = 0.77, p < 0.01) at one year. Further stepwise regression indicated that 
      including AD (p = 0.0001) and presence of HC (p < 0.0001) in the regression model 
      provided the best model fit for one year ISNCSCI (r(2) = 0.93). The AD is a more 
      specific parameter for axonal injury than radial diffusivity; this may indicate 
      that axonal injury in the cord is the main factor affecting patient recovery. Our 
      study demonstrates DTI measurement at the CSCI is a potential neuroimaging 
      biomarker in predicting long-term neurological and functional outcome in blunt 
      CSCI.
FAU - Shanmuganathan, Kathirkamanathan
AU  - Shanmuganathan K
AD  - 1 Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland 
      School of Medicine , Baltimore, Maryland.
FAU - Zhuo, Jaichen
AU  - Zhuo J
AD  - 1 Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland 
      School of Medicine , Baltimore, Maryland.
FAU - Chen, Hegang H
AU  - Chen HH
AD  - 2 Department of Epidemiology and Public Health, University of Maryland School of 
      Medicine , Baltimore, Maryland.
FAU - Aarabi, Bizhan
AU  - Aarabi B
AD  - 3 Department of Neurosurgery, University of Maryland School of Medicine , 
      Baltimore, Maryland.
FAU - Adams, Jason
AU  - Adams J
AD  - 4 Department of Rehabilitation Services, University of Maryland School of 
      Medicine , Baltimore, Maryland.
FAU - Miller, Catriona
AU  - Miller C
AD  - 5 Department of Aeromedical Research, U.S. Air Force School of Aerospace 
      Medicine, Research Initiatives, US Air Force c-STARS Baltimore, Baltimore, 
      Maryland.
FAU - Menakar, Jay
AU  - Menakar J
AD  - 6 R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine 
      , Baltimore, Maryland.
FAU - Gullapalli, Rao P
AU  - Gullapalli RP
AD  - 1 Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland 
      School of Medicine , Baltimore, Maryland.
FAU - Mirvis, Stuart E
AU  - Mirvis SE
AD  - 1 Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland 
      School of Medicine , Baltimore, Maryland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170628
PL  - United States
TA  - J Neurotrauma
JT  - Journal of neurotrauma
JID - 8811626
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cervical Vertebrae
MH  - Diffusion Tensor Imaging/*methods
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Recovery of Function
MH  - Spinal Cord Injuries/*diagnostic imaging/pathology
MH  - Time Factors
MH  - Young Adult
OTO - NOTNLM
OT  - cervical spine
OT  - diffusion tensor imaging
OT  - magnetic resonance
OT  - traumatic spinal cord injury
EDAT- 2017/04/08 06:00
MHDA- 2018/06/23 06:00
CRDT- 2017/04/08 06:00
PHST- 2017/04/08 06:00 [pubmed]
PHST- 2018/06/23 06:00 [medline]
PHST- 2017/04/08 06:00 [entrez]
AID - 10.1089/neu.2016.4901 [doi]
PST - ppublish
SO  - J Neurotrauma. 2017 Nov 1;34(21):2964-2971. doi: 10.1089/neu.2016.4901. Epub 2017 
      Jun 28.