PMID- 28385300 OWN - NLM STAT- MEDLINE DCOM- 20170721 LR - 20180518 IS - 1549-4713 (Electronic) IS - 0161-6420 (Linking) VI - 124 IP - 7 DP - 2017 Jul TI - Quality of Life and Functional Vision in Children with Glaucoma. PG - 1048-1055 LID - S0161-6420(16)31931-5 [pii] LID - 10.1016/j.ophtha.2017.02.024 [doi] AB - PURPOSE: To evaluate the effect of glaucoma on functional vision and on vision-related (VR) and health-related (HR) quality of life (QoL) in children up to 16 years of age. DESIGN: Cross-sectional observational study. PARTICIPANTS: One hundred nineteen children 2 to 16 years of age (mean age, 9.4 years; standard deviation [SD], 4.56 years) with glaucoma and their parents. METHODS: Completion of 3 validated instruments for children to assess (1) functional visual ability (FVA) with the Cardiff Visual Ability Questionnaire for Children (CVAQC), (2) VR QoL with the Impact of Vision Impairment for Children (IVI-C), and (3) HR QoL with the Pediatric Quality of Life Inventory (PedsQL) version 4.0. MAIN OUTCOME MEASURES: Cardiff Visual Ability Questionnaire for Children, IVI-C, and PedsQL scores. RESULTS: Scores for FVA, VR QoL, and HR QoL were reduced in children with glaucoma: median CVAQC score, -1.24 (interquartile range [IQR], -2.2 to -0.11; range, -3.00 higher visual ability to +2.80 lower visual ability); mean IVI-C score, 67.3 (SD, 14.4; normal VR QoL, 96); median PedsQL self-report, 78.8 (IQR, 67.4-90.2); parent report, 71.2 (IQR, 55.7-85.8); and family impact score, 74.3 (IQR, 56.9-88.5; normal HR QoL, 100). Psychosocial subscores were lower than physical subscores on the PedsQL. Older children reported less impairment on CVAQC, IVI-C, and PedsQL than younger children. Parents reported greater impact on their child's HR QoL than children reported themselves. CONCLUSIONS: Glaucoma and its management have a marked impact on a child's FVA and QoL. Children with glaucoma report HR QoL scores similar to those described by children with severe congenital cardiac defects, who have undergone liver transplants, or who have acute lymphoblastic leukemia. CI - Copyright (c) 2017 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved. FAU - Dahlmann-Noor, Annegret AU - Dahlmann-Noor A AD - National Institute of Health Research Biomedical Research Centre for Ophthalmology, University College London Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom; Paediatric Service, Moorfields Eye Hospital, London, United Kingdom. Electronic address: annegret.dahlmann-noor@moorfields.nhs.uk. FAU - Tailor, Vijay AU - Tailor V AD - National Institute of Health Research Biomedical Research Centre for Ophthalmology, University College London Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom. FAU - Bunce, Catey AU - Bunce C AD - National Institute of Health Research Biomedical Research Centre for Ophthalmology, University College London Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom; London School of Hygiene & Tropical Medicine, London, United Kingdom; Primary Care & Public Health Sciences, King's College London, London, United Kingdom. FAU - Abou-Rayyah, Yassir AU - Abou-Rayyah Y AD - National Institute of Health Research Biomedical Research Centre for Ophthalmology, University College London Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom; Adnexal Service, Moorfields Eye Hospital, London, United Kingdom. FAU - Adams, Gillian AU - Adams G AD - National Institute of Health Research Biomedical Research Centre for Ophthalmology, University College London Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom; Paediatric Service, Moorfields Eye Hospital, London, United Kingdom. FAU - Brookes, John AU - Brookes J AD - National Institute of Health Research Biomedical Research Centre for Ophthalmology, University College London Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom; Glaucoma Service, Moorfields Eye Hospital, London, United Kingdom. FAU - Khaw, Peng T AU - Khaw PT AD - National Institute of Health Research Biomedical Research Centre for Ophthalmology, University College London Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom; Glaucoma Service, Moorfields Eye Hospital, London, United Kingdom. FAU - Papadopoulos, Maria AU - Papadopoulos M AD - National Institute of Health Research Biomedical Research Centre for Ophthalmology, University College London Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom; Glaucoma Service, Moorfields Eye Hospital, London, United Kingdom. LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20170404 PL - United States TA - Ophthalmology JT - Ophthalmology JID - 7802443 SB - IM MH - *Activities of Daily Living MH - Adolescent MH - Child MH - Child, Preschool MH - Cross-Sectional Studies MH - Female MH - Glaucoma/physiopathology/*psychology MH - Humans MH - Intraocular Pressure/physiology MH - Male MH - *Quality of Life MH - *Self Report MH - *Surveys and Questionnaires MH - Visual Acuity/*physiology EDAT- 2017/04/08 06:00 MHDA- 2017/07/22 06:00 CRDT- 2017/04/08 06:00 PHST- 2016/11/09 00:00 [received] PHST- 2017/02/17 00:00 [revised] PHST- 2017/02/17 00:00 [accepted] PHST- 2017/04/08 06:00 [pubmed] PHST- 2017/07/22 06:00 [medline] PHST- 2017/04/08 06:00 [entrez] AID - S0161-6420(16)31931-5 [pii] AID - 10.1016/j.ophtha.2017.02.024 [doi] PST - ppublish SO - Ophthalmology. 2017 Jul;124(7):1048-1055. doi: 10.1016/j.ophtha.2017.02.024. Epub 2017 Apr 4.