PMID- 28386186
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1319-562X (Print)
IS  - 2213-7106 (Electronic)
IS  - 2213-7106 (Linking)
VI  - 24
IP  - 3
DP  - 2017 Mar
TI  - Mechanistic prediction of food effects for Compound A tablet using PBPK model.
PG  - 603-609
LID - 10.1016/j.sjbs.2017.01.032 [doi]
AB  - Physiologically based pharmacokinetic (PBPK) modeling has been extensively used 
      to study the factors of effect drug absorption, distribution, metabolize and 
      extraction progress in human. In this study, Compound A(CPD A) is a BCS Class II 
      drug, which has been extensive applied in clinical as lipid-lowering drug, 
      administered orally after food, they displayed positive food effects in human, A 
      PBPK model was built to mechanistic investigate the food effect of CPD A tablet 
      in our study. By using gastroplus software, the PBPK models accurately predicted 
      the results of food effects and predicted data were within 2-fold error of the 
      observed results. The PBPK model mechanistic illuminated the changes of 
      pharmacokinetic values for the positive food effects of the compound in human. 
      Here in, the PBPK modeling which were combined with ACAT absorption models in it, 
      successfully simulated the food effect in human of the drug. The simulation 
      results were proved that PBPK model can be able to serve as a potential tool to 
      predict the food effect on certain oral drugs.
FAU - Li, Xueqing
AU  - Li X
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Shi, Lei
AU  - Shi L
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Tang, Xiuling
AU  - Tang X
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Wang, Qinghui
AU  - Wang Q
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Zhou, Lun
AU  - Zhou L
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Song, Wei
AU  - Song W
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Feng, Zhijun
AU  - Feng Z
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Ge, Jie
AU  - Ge J
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Li, Jian Kang
AU  - Li JK
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Yang, Lin
AU  - Yang L
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Wen, Aidong
AU  - Wen A
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
LA  - eng
PT  - Journal Article
DEP - 20170211
PL  - Saudi Arabia
TA  - Saudi J Biol Sci
JT  - Saudi journal of biological sciences
JID - 101543796
PMC - PMC5372427
OTO - NOTNLM
OT  - ACAT
OT  - Food effects
OT  - PBPK
OT  - Pharmacokinetic
OT  - Prediction
EDAT- 2017/04/08 06:00
MHDA- 2017/04/08 06:01
PMCR- 2017/02/11
CRDT- 2017/04/08 06:00
PHST- 2016/09/04 00:00 [received]
PHST- 2016/12/30 00:00 [revised]
PHST- 2017/01/08 00:00 [accepted]
PHST- 2017/04/08 06:00 [entrez]
PHST- 2017/04/08 06:00 [pubmed]
PHST- 2017/04/08 06:01 [medline]
PHST- 2017/02/11 00:00 [pmc-release]
AID - S1319-562X(17)30041-4 [pii]
AID - 10.1016/j.sjbs.2017.01.032 [doi]
PST - ppublish
SO  - Saudi J Biol Sci. 2017 Mar;24(3):603-609. doi: 10.1016/j.sjbs.2017.01.032. Epub 
      2017 Feb 11.