PMID- 28386507
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240324
IS  - 2090-6900 (Print)
IS  - 2090-6919 (Electronic)
VI  - 2017
DP  - 2017
TI  - An Unusual Case of Resistant Hypokalaemia in a Patient with Large Bowel 
      Obstruction Secondary to Neuroendocrine Carcinoma of the Prostate.
PG  - 2394365
LID - 10.1155/2017/2394365 [doi]
LID - 2394365
AB  - Neuroendocrine Carcinoma of the Prostate (NECP) is rare and only few cases have 
      been reported, constituting less than 0.5% of prostatic malignancies. We report a 
      rare case of large bowel obstruction from NECP posing a further challenge in 
      management due to resistant hypokalaemia. A 70-year-old man presented with 
      clinical signs of large bowel obstruction who was known to have prostatic 
      carcinoma three years ago, treated initially with hormone therapy then 
      chemoradiation. The blood profile showed a severe hypokalaemia and CT scan 
      revealed liver and lung metastases apart from confirming large bowel obstruction 
      from local invasion of NECP. Severe hypokalaemia was believed to be caused by 
      paraneoplastic syndrome from tumor burden or by recent administration of 
      Etoposide. Intensive potassium correction through a central venous access in 
      maximal doses of 150 mmol/24 hours under cardiac monitoring finally raised serum 
      potassium to 3.8 mmol/L. This safe period allowed us to perform a trephine 
      colostomy at the left iliac fossa. The postoperative period was relatively 
      uneventful. This first case report is presenting a rare cause of large bowel 
      obstruction from a neuroendocrine carcinoma of prostate and highlights the 
      importance of an early, intensive correction of electrolytes in patients with 
      large tumor burden from NECP.
FAU - Mathuram Thiyagarajan, Umasankar
AU  - Mathuram Thiyagarajan U
AUID- ORCID: 0000-0001-7272-5252
AD  - Department of Hepatobiliary Surgery, Royal Free Hospital, Pond Street, London NW3 
      2QG, UK.
FAU - Ponnuswamy, A
AU  - Ponnuswamy A
AUID- ORCID: 0000-0002-6704-1347
AD  - Department of Paediatrics, Eastbourne District General Hospital, Eastbourne BN21 
      2UD, UK.
FAU - Bagul, A
AU  - Bagul A
AD  - Department of Transplantation, Leicester General Hospital, Leicester LE5 4PW, UK.
FAU - Gupta, A
AU  - Gupta A
AD  - Department of General Surgery, St Helier Hospital, Carshalton SM5 1AA, UK.
LA  - eng
PT  - Case Reports
DEP - 20170313
PL  - United States
TA  - Case Rep Surg
JT  - Case reports in surgery
JID - 101580191
PMC - PMC5366774
EDAT- 2017/04/08 06:00
MHDA- 2017/04/08 06:01
PMCR- 2017/03/13
CRDT- 2017/04/08 06:00
PHST- 2016/07/29 00:00 [received]
PHST- 2017/02/14 00:00 [revised]
PHST- 2017/02/20 00:00 [accepted]
PHST- 2017/04/08 06:00 [entrez]
PHST- 2017/04/08 06:00 [pubmed]
PHST- 2017/04/08 06:01 [medline]
PHST- 2017/03/13 00:00 [pmc-release]
AID - 10.1155/2017/2394365 [doi]
PST - ppublish
SO  - Case Rep Surg. 2017;2017:2394365. doi: 10.1155/2017/2394365. Epub 2017 Mar 13.