PMID- 28386917 OWN - NLM STAT- MEDLINE DCOM- 20181016 LR - 20220408 IS - 1879-0844 (Electronic) IS - 1388-9842 (Linking) VI - 19 IP - 12 DP - 2017 Dec TI - Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry. PG - 1574-1585 LID - 10.1002/ejhf.813 [doi] AB - AIMS: The objectives of the present study were to describe epidemiology and outcomes in ambulatory heart failure (HF) patients stratified by left ventricular ejection fraction (LVEF) and to identify predictors for mortality at 1 year in each group. METHODS AND RESULTS: The European Society of Cardiology Heart Failure Long-Term Registry is a prospective, observational study collecting epidemiological information and 1-year follow-up data in 9134 HF patients. Patients were classified according to baseline LVEF into HF with reduced EF [EF <40% (HFrEF)], mid-range EF [EF 40-50% (HFmrEF)] and preserved EF [EF >50% (HFpEF)]. In comparison with HFpEF subjects, patients with HFrEF were younger (64 years vs. 69 years), more commonly male (78% vs. 52%), more likely to have an ischaemic aetiology (49% vs. 24%) and left bundle branch block (24% vs. 9%), but less likely to have hypertension (56% vs. 67%) or atrial fibrillation (18% vs. 32%). The HFmrEF group resembled the HFrEF group in some features, including age, gender and ischaemic aetiology, but had less left ventricular and atrial dilation. Mortality at 1 year differed significantly between HFrEF and HFpEF (8.8% vs. 6.3%); HFmrEF patients experienced intermediate rates (7.6%). Age, New York Heart Association (NYHA) class III/IV status and chronic kidney disease predicted mortality in all LVEF groups. Low systolic blood pressure and high heart rate were predictors for mortality in HFrEF and HFmrEF. A lower body mass index was independently associated with mortality in HFrEF and HFpEF patients. Atrial fibrillation predicted mortality in HFpEF patients. CONCLUSIONS: Heart failure patients stratified according to different categories of LVEF represent diverse phenotypes of demography, clinical presentation, aetiology and outcomes at 1 year. Differences in predictors for mortality might improve risk stratification and management goals. CI - (c) 2017 The Authors. European Journal of Heart Failure (c) 2017 European Society of Cardiology. FAU - Chioncel, Ovidiu AU - Chioncel O AD - University of Medicine Carol Davila, Bucuresti; Institutul de Urgente Boli Cardiovasculare C.C.Iliescu, Bucuresti, Romania. FAU - Lainscak, Mitja AU - Lainscak M AD - Department of Cardiology, General Hospital Celje, Slovenia. FAU - Seferovic, Petar M AU - Seferovic PM AD - Department of Internal Medicine, Belgrade University School of Medicine and Heart Failure Centre, Belgrade University Medical Centre, Belgrade, Serbia. FAU - Anker, Stefan D AU - Anker SD AD - Innovative Clinical Trials, Department of Cardiology and Pneumology, University Medical Center Gottingen (UMG), Gottingen, Germany. FAU - Crespo-Leiro, Maria G AU - Crespo-Leiro MG AD - Unidad de Insuficiencia Cardiaca Avanzada y Trasplante Cardiaco, Complexo Hospitalario Universitario A Coruna, CHUAC, LaCoruna, Spain. FAU - Harjola, Veli-Pekka AU - Harjola VP AD - Emergency Medicine, Helsinki University, Department of Emergency Medicine and Services, Helsinki University Hospital, Helsinki, Finland. FAU - Parissis, John AU - Parissis J AD - Attikon University Hospital, Athens, Greece. FAU - Laroche, Cecile AU - Laroche C AD - EURObservational Research Programme, European Society of Cardiology, Sophia-Antipolis, France. FAU - Piepoli, Massimo Francesco AU - Piepoli MF AD - Heart Failure Unit, Cardiac Department, Guglielmo da Saliceto Hospital, AUSL Piacenza, Italy. FAU - Fonseca, Candida AU - Fonseca C AD - Heart Failure Unit, S. Francisco Xavier Hospital, Centro Hospitalar Lisboa Ocidental. NOVA Medical School, Faculdade de Ciencias Medicas, Universidade Nova de Lisboa, Portugal. FAU - Mebazaa, Alexandre AU - Mebazaa A AD - University Paris Diderot, Sorbonne Paris Cite, Paris, France; 4APHP, Department of Anaesthesia and Critical Care, Hopitaux Universitaires Saint Louis-Lariboisiere, Paris, France. FAU - Lund, Lars AU - Lund L AD - Karolinska Institutet, Department of Medicine and Karolinska University Hospital, Stockholm, Sweden. FAU - Ambrosio, Giuseppe A AU - Ambrosio GA AD - University of Perugia School of Medicine, Perugia, Italy. FAU - Coats, Andrew J AU - Coats AJ AD - Monash University, Australia and University of Warwick, Coventry, UK. FAU - Ferrari, Roberto AU - Ferrari R AD - Department of Cardiology and LTTA Centre, University Hospital of Ferrara and Maria Cecilia Hospital, GVM Care and Research, ES Health Science Foundation, Cotignola, Italy. FAU - Ruschitzka, Frank AU - Ruschitzka F AD - Department of Cardiology, Heart Failure Clinic and Transplantation, University Heart Centre Zurich, Zurich, Switzerland. FAU - Maggioni, Aldo P AU - Maggioni AP AD - ANMCO Research Center, Florence, Italy. FAU - Filippatos, Gerasimos AU - Filippatos G AD - National and Kapodistrian University of Athens, School of Medicine, University Hospital Attikon, Athens, Greece. LA - eng PT - Journal Article PT - Multicenter Study PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20170406 PL - England TA - Eur J Heart Fail JT - European journal of heart failure JID - 100887595 SB - IM CIN - Heart. 2017 Jul;103(13):979-981. PMID: 28456754 MH - Aged MH - Cardiology MH - Cause of Death/trends MH - Europe/epidemiology MH - Female MH - Follow-Up Studies MH - Heart Failure/*epidemiology/physiopathology MH - Hospitalization/trends MH - Humans MH - Incidence MH - Male MH - Middle Aged MH - Prognosis MH - Prospective Studies MH - *Registries MH - Severity of Illness Index MH - Societies, Medical MH - *Stroke Volume MH - Time Factors MH - Ventricular Function, Left/*physiology OTO - NOTNLM OT - Ambulatory OT - Chronic OT - Heart failure OT - Left ventricular ejection fraction OT - Outcomes EDAT- 2017/04/08 06:00 MHDA- 2018/10/17 06:00 CRDT- 2017/04/08 06:00 PHST- 2016/10/21 00:00 [received] PHST- 2017/02/06 00:00 [revised] PHST- 2017/02/21 00:00 [accepted] PHST- 2017/04/08 06:00 [pubmed] PHST- 2018/10/17 06:00 [medline] PHST- 2017/04/08 06:00 [entrez] AID - 10.1002/ejhf.813 [doi] PST - ppublish SO - Eur J Heart Fail. 2017 Dec;19(12):1574-1585. doi: 10.1002/ejhf.813. Epub 2017 Apr 6.