PMID- 28389595
OWN - NLM
STAT- MEDLINE
DCOM- 20180220
LR  - 20220409
IS  - 1943-4456 (Electronic)
IS  - 0091-7451 (Print)
IS  - 0091-7451 (Linking)
VI  - 81
DP  - 2016
TI  - Cancer Immunogenomics: Computational Neoantigen Identification and Vaccine 
      Design.
PG  - 105-111
LID - 10.1101/sqb.2016.81.030726 [doi]
AB  - The application of modern high-throughput genomics to the study of cancer genomes 
      has exploded in the past few years, yielding unanticipated insights into the 
      myriad and complex combinations of genomic alterations that lead to the 
      development of cancers. Coincident with these genomic approaches have been 
      computational analyses that are capable of multiplex evaluations of genomic data 
      toward specific therapeutic end points. One such approach is called 
      "immunogenomics" and is now being developed to interpret protein-altering changes 
      in cancer cells in the context of predicted preferential binding of these altered 
      peptides by the patient's immune molecules, specifically human leukocyte antigen 
      (HLA) class I and II proteins. One goal of immunogenomics is to identify those 
      cancer-specific alterations that are likely to elicit an immune response that is 
      highly specific to the patient's cancer cells following stimulation by a 
      personalized vaccine. The elements of such an approach are outlined herein and 
      constitute an emerging therapeutic option for cancer patients.
CI  - (c) 2016 Hundal et al; Published by Cold Spring Harbor Laboratory Press.
FAU - Hundal, Jasreet
AU  - Hundal J
AD  - McDonnell Genome Institute at Washington University School of Medicine, St. 
      Louis, Missouri 63108.
FAU - Miller, Christopher A
AU  - Miller CA
AD  - McDonnell Genome Institute at Washington University School of Medicine, St. 
      Louis, Missouri 63108.
AD  - Department of Medicine, Division of Oncology, Washington University School of 
      Medicine, St. Louis, Missouri 63110.
FAU - Griffith, Malachi
AU  - Griffith M
AD  - McDonnell Genome Institute at Washington University School of Medicine, St. 
      Louis, Missouri 63108.
AD  - Department of Medicine, Division of Oncology, Washington University School of 
      Medicine, St. Louis, Missouri 63110.
FAU - Griffith, Obi L
AU  - Griffith OL
AD  - McDonnell Genome Institute at Washington University School of Medicine, St. 
      Louis, Missouri 63108.
AD  - Department of Medicine, Division of Oncology, Washington University School of 
      Medicine, St. Louis, Missouri 63110.
FAU - Walker, Jason
AU  - Walker J
AD  - McDonnell Genome Institute at Washington University School of Medicine, St. 
      Louis, Missouri 63108.
FAU - Kiwala, Susanna
AU  - Kiwala S
AD  - McDonnell Genome Institute at Washington University School of Medicine, St. 
      Louis, Missouri 63108.
FAU - Graubert, Aaron
AU  - Graubert A
AD  - McDonnell Genome Institute at Washington University School of Medicine, St. 
      Louis, Missouri 63108.
FAU - McMichael, Joshua
AU  - McMichael J
AD  - McDonnell Genome Institute at Washington University School of Medicine, St. 
      Louis, Missouri 63108.
FAU - Coffman, Adam
AU  - Coffman A
AD  - McDonnell Genome Institute at Washington University School of Medicine, St. 
      Louis, Missouri 63108.
FAU - Mardis, Elaine R
AU  - Mardis ER
AD  - Nationwide Children's Hospital, Institute for Genomic Medicine, Columbus, Ohio 
      43205.
LA  - eng
GR  - R00 HG007940/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20170407
PL  - United States
TA  - Cold Spring Harb Symp Quant Biol
JT  - Cold Spring Harbor symposia on quantitative biology
JID - 1256107
RN  - 0 (Peptides)
RN  - 0 (Vaccines)
RN  - 0 (Vaccines, Synthetic)
SB  - IM
MH  - Animals
MH  - Computers, Molecular
MH  - *Genomics/methods
MH  - Humans
MH  - Neoplasms/*immunology
MH  - Peptides/immunology
MH  - *Vaccines/therapeutic use
MH  - Vaccines, Synthetic/*immunology
PMC - PMC5702270
MID - NIHMS915058
EDAT- 2017/04/09 06:00
MHDA- 2018/02/21 06:00
PMCR- 2017/11/25
CRDT- 2017/04/09 06:00
PHST- 2017/04/09 06:00 [pubmed]
PHST- 2018/02/21 06:00 [medline]
PHST- 2017/04/09 06:00 [entrez]
PHST- 2017/11/25 00:00 [pmc-release]
AID - sqb.2016.81.030726 [pii]
AID - 10.1101/sqb.2016.81.030726 [doi]
PST - ppublish
SO  - Cold Spring Harb Symp Quant Biol. 2016;81:105-111. doi: 
      10.1101/sqb.2016.81.030726. Epub 2017 Apr 7.