PMID- 2839106
OWN - NLM
STAT- MEDLINE
DCOM- 19880729
LR  - 20041117
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 23
IP  - 5
DP  - 1988 May
TI  - Peripheral neuropathy in the acquired immunodeficiency syndrome.
PG  - 485-92
AB  - The histopathological and immunopathological features of peripheral neuropathy 
      were investigated in 21 patients with the acquired immunopathological syndrome 
      (AIDS) or AIDS-related complex (ARC). Clinical syndromes observed in the 11 (52%) 
      symptomatic patients included distal symmetrical polyneuropathy (DSPN) and 
      chronic inflammatory demyelinative polyneuropathy (CIDP). Specimens from 19 of 20 
      patients (95%), both symptomatic and asymptomatic, had histopathological evidence 
      of moderate or severe demyelination (79%), axonal degeneration (36%), and 
      mononuclear cell inflammation (37%). Nerves from patients with CIDP and DSPN 
      showed similar degrees of demyelination and axonal degeneration, but inflammation 
      was more intense in CIDP. Immunohistochemical staining identified the majority of 
      inflammatory cells as T lymphocytes or macrophages, with a predominance of CD8+ 
      cytotoxic/suppressor cells. Diffuse immunostaining for human leukocyte antigen 
      (HLA)-DR was present on endothelial cells, mononuclear inflammatory cells, and 
      Schwann cells, and variable patchy immunostaining for HLA-DR was present on nerve 
      fibers. Control nerve specimens showed staining for HLA-DR limited to 
      endothelial, and a few mononuclear cells. The patterns of immunostaining were 
      similar for AIDS and ARC patients. Human immunodeficiency virus (HIV) was 
      cultured from peripheral nerve in 3 patients, but HIV antigen was not detected by 
      immunohistochemical staining of 8 specimens. The findings implicate HIV infection 
      in nerve, with T cell- and macrophage-mediated tissue destruction as the 
      pathogenetic mechanism of the AIDS/ARC neuropathy.
FAU - de la Monte, S M
AU  - de la Monte SM
AD  - Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 
      Boston 02114.
FAU - Gabuzda, D H
AU  - Gabuzda DH
FAU - Ho, D D
AU  - Ho DD
FAU - Brown, R H Jr
AU  - Brown RH Jr
FAU - Hedley-Whyte, E T
AU  - Hedley-Whyte ET
FAU - Schooley, R T
AU  - Schooley RT
FAU - Hirsch, M S
AU  - Hirsch MS
FAU - Bhan, A K
AU  - Bhan AK
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
SB  - IM
MH  - AIDS-Related Complex/*complications/immunology/pathology
MH  - Acquired Immunodeficiency Syndrome/*complications/immunology/pathology
MH  - Adult
MH  - Aged
MH  - HIV/isolation & purification
MH  - Humans
MH  - Leukocytes/immunology
MH  - Lymphocytes/immunology
MH  - Male
MH  - Middle Aged
MH  - Nervous System Diseases/etiology/pathology
MH  - Opportunistic Infections/etiology
MH  - Peripheral Nervous System Diseases/*etiology/microbiology/pathology
MH  - Pneumonia, Pneumocystis/etiology
EDAT- 1988/05/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1988/05/01 00:00
PHST- 1988/05/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1988/05/01 00:00 [entrez]
AID - 10.1002/ana.410230510 [doi]
PST - ppublish
SO  - Ann Neurol. 1988 May;23(5):485-92. doi: 10.1002/ana.410230510.