PMID- 28392271
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20180816
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 93
DP  - 2017 Jul
TI  - Brain-derived neurotrophic factor (BDNF) serum basal levels is not affected by 
      power training in mobility-limited older adults - A randomized controlled trial.
PG  - 29-35
LID - S0531-5565(16)30340-0 [pii]
LID - 10.1016/j.exger.2017.03.019 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a potential important factor involved 
      in neuroplasticity, and may be a mediator for eliciting adaptations in 
      neuromuscular function and physical function in older individuals following 
      physical training. As power training taxes the neural system to a very high 
      extent, it may be particularly effective in terms of eliciting increases in 
      systemic BDNF levels. We examined the effects of 12weeks of power training on 
      mature BDNF (mBDNF) and total BDNF (tBDNF) in mobility-limited older adults from 
      the Healthy Ageing Network of Competence (HANC) study. We included 47 older men 
      and women: n=22 in the training group (TG: progressive high intensity power 
      training, 2 sessions per week; age 82.7+/-5.4years, 55% women) and n=25 in the 
      control group (CG: no interventions; age 82.2+/-4.5years, 76% women). Following 
      overnight fasting, basal serum levels of mBDNF and tBDNF were assessed (human 
      ELISA kits) at baseline and post-intervention. At baseline, mBDNF and tBDNF 
      levels were comparable in the two groups, TG and CG. Post-intervention, no 
      significant within-group or between-group changes were observed in mBDNF or 
      tBDNF. Moreover, when divided into responder tertiles based upon changes in mBDNF 
      and tBDNF (i.e. decliners, maintainers, improvers), respectively, comparable 
      findings were observed for TG and CG. Altogether, basal systemic levels of serum 
      mBDNF and tBDNF are not affected in mobility-limited older adults following 
      12-weeks of power training, and do not appear to be a major mechanistic factor 
      mediating neuroplasticity in mobility-limited older adults.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Hvid, L G
AU  - Hvid LG
AD  - Department of Sports Science and Clinical Biomechanics, University of Southern 
      Denmark (SDU), Odense, Denmark. Electronic address: lhvid@health.sdu.dk.
FAU - Nielsen, M K F
AU  - Nielsen MKF
AD  - Department of Sports Science and Clinical Biomechanics, University of Southern 
      Denmark (SDU), Odense, Denmark.
FAU - Simonsen, C
AU  - Simonsen C
AD  - Department of Sports Science and Clinical Biomechanics, University of Southern 
      Denmark (SDU), Odense, Denmark.
FAU - Andersen, M
AU  - Andersen M
AD  - Department of Endocrinology, Odense University Hospital, Odense, Denmark.
FAU - Caserotti, P
AU  - Caserotti P
AD  - Department of Sports Science and Clinical Biomechanics, University of Southern 
      Denmark (SDU), Odense, Denmark; National Institutes of Health, National Institute 
      on Aging, Laboratory of Epidemiology and Population Sciences (LPES), Bethesda, 
      MD, United States.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170407
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Mobility Limitation
MH  - Neuronal Plasticity/physiology
MH  - Resistance Training/*methods
MH  - Single-Blind Method
OTO - NOTNLM
OT  - Aging
OT  - Brain-derived neurotrophic factor (BDNF)
OT  - Neuroplasticity
OT  - Power training
EDAT- 2017/04/11 06:00
MHDA- 2018/01/06 06:00
CRDT- 2017/04/11 06:00
PHST- 2016/09/12 00:00 [received]
PHST- 2017/01/28 00:00 [revised]
PHST- 2017/03/13 00:00 [accepted]
PHST- 2017/04/11 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
PHST- 2017/04/11 06:00 [entrez]
AID - S0531-5565(16)30340-0 [pii]
AID - 10.1016/j.exger.2017.03.019 [doi]
PST - ppublish
SO  - Exp Gerontol. 2017 Jul;93:29-35. doi: 10.1016/j.exger.2017.03.019. Epub 2017 Apr 
      7.