PMID- 28392387
OWN - NLM
STAT- MEDLINE
DCOM- 20180312
LR  - 20180312
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 102
DP  - 2017 Sep
TI  - Functionally modified polyacrylamide-graft-gum karaya pH-sensitive spray dried 
      microspheres for colon targeting of an anti-cancer drug.
PG  - 829-839
LID - S0141-8130(16)32774-X [pii]
LID - 10.1016/j.ijbiomac.2017.04.023 [doi]
AB  - An effort was made to formulate and evaluate pH-sensitive spray dried 
      microspheres using hydrolyzed polyacrylamide-graft-gum karaya (PAAm-g-GK) for 
      colon specific delivery of an anti-cancer agent, capecitabine. The synthesis of 
      pH-sensitive PAAm-g-GK copolymer was done by free radical polymerization followed 
      by alkaline hydrolysis and characterized satisfactorily. The microspheres were 
      spherical in shape; drug entrapment efficiency was found to be in the range of 
      77.30% to 88.74%. Pulsatile swelling study indicates that the PAAm-g-GK consists 
      of considerable pH-sensitivity. The in-vitro drug release suggested that the 
      microspheres prepared using native GK were incapable to retard the drug release 
      within 5h in the environment of stomach and small intestine. While, those 
      microspheres prepared using pH-sensitive PAAm-g-GK copolymer having crosslinked 
      with glutaraldehyde (GA), released little amount of drug within 5h, but maximum 
      amount of drug was targeted to colonic region in a controlled manner up to 24h. 
      For example, GK10 Microspheres showed only 19.16% drug release at the end of 5th 
      h, while about 80.14% of drug was targeted to colonic region. Cross-linking with 
      GA reduced the early drug release in the upper part of gastrointestinal tract and 
      guaranteed maximum drug release in the colonic region. A rapid enhancement in 
      drug release was witnessed in rat caecal content medium due to the action of 
      colonic bacteria on PAAm-g-GK copolymer.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Alange, Vijaykumar V
AU  - Alange VV
AD  - Department of Pharmaceutics, BLDEA's SSM College of Pharmacy and Research Centre, 
      BLDE University Campus, Vijayapur (Bijapur), 586103, Karnataka, India.
FAU - Birajdar, Ravindra P
AU  - Birajdar RP
AD  - Department of Pharmaceutics, BLDEA's SSM College of Pharmacy and Research Centre, 
      BLDE University Campus, Vijayapur (Bijapur), 586103, Karnataka, India.
FAU - Kulkarni, Raghavendra V
AU  - Kulkarni RV
AD  - Department of Pharmaceutics, BLDEA's SSM College of Pharmacy and Research Centre, 
      BLDE University Campus, Vijayapur (Bijapur), 586103, Karnataka, India. Electronic 
      address: pharma_75raghu@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20170406
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Acrylic Resins)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
RN  - 6804DJ8Z9U (Capecitabine)
RN  - 9000-36-6 (Karaya Gum)
RN  - 9003-05-8 (polyacrylamide)
SB  - IM
MH  - Acrylic Resins/*chemistry
MH  - Animals
MH  - Antineoplastic Agents/*chemistry/*metabolism
MH  - Capecitabine/chemistry/metabolism
MH  - Cecum/metabolism
MH  - Colon/*metabolism
MH  - Drug Carriers/*chemistry
MH  - Drug Liberation
MH  - Hydrogen-Ion Concentration
MH  - Karaya Gum/*chemistry
MH  - *Microspheres
MH  - Rats
OTO - NOTNLM
OT  - Capecitabine
OT  - Colon targeting
OT  - Gum karaya
OT  - Spray drying
OT  - pH-sensitive graft copolymer
EDAT- 2017/04/11 06:00
MHDA- 2018/03/13 06:00
CRDT- 2017/04/11 06:00
PHST- 2016/12/05 00:00 [received]
PHST- 2017/03/26 00:00 [revised]
PHST- 2017/04/05 00:00 [accepted]
PHST- 2017/04/11 06:00 [pubmed]
PHST- 2018/03/13 06:00 [medline]
PHST- 2017/04/11 06:00 [entrez]
AID - S0141-8130(16)32774-X [pii]
AID - 10.1016/j.ijbiomac.2017.04.023 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2017 Sep;102:829-839. doi: 10.1016/j.ijbiomac.2017.04.023. 
      Epub 2017 Apr 6.