PMID- 28392404
OWN - NLM
STAT- MEDLINE
DCOM- 20171225
LR  - 20180703
IS  - 1873-2194 (Electronic)
IS  - 0163-7827 (Linking)
VI  - 66
DP  - 2017 Apr
TI  - A global perspective on FOXO1 in lipid metabolism and lipid-related diseases.
PG  - 42-49
LID - S0163-7827(16)30048-0 [pii]
LID - 10.1016/j.plipres.2017.04.002 [doi]
AB  - Lipid metabolism is a complex physiological process that is involved in nutrient 
      adjustment, hormone regulation, and homeostasis. An unhealthy lifestyle and 
      chronic nutrient overload can cause lipid metabolism disorders, which may lead to 
      serious lipid-related diseases, including obesity, non-alcoholic fatty liver 
      disease (NAFLD), and type 2 diabetes mellitus (T2DM). Therefore, tools for 
      preventing dysfunctional lipid metabolism are urgently needed. The transcription 
      factor forkhead box protein O1 (FOXO1) is involved in lipid metabolism and plays 
      a critical role in the development of lipid-related diseases. In this review, we 
      provide a global perspective on the role of FOXO1 in lipid metabolism and 
      lipid-related diseases. The information included here may be useful for the 
      design of future studies and advancing investigations of FOXO1 as a therapeutic 
      target.
CI  - Copyright (c) 2017. Published by Elsevier Ltd.
FAU - Li, Yue
AU  - Li Y
AD  - Department of Thoracic and Cardiovascular Surgery, Affiliated Drum Tower Hospital 
      of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, 
      Jiangsu, China; Department of Biomedical Engineering, The Fourth Military Medical 
      University, 169 Changle West Road, Xi'an 710032, China.
FAU - Ma, Zhiqiang
AU  - Ma Z
AD  - Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical 
      University, 1 Xinsi Road, Xi'an 710038, China.
FAU - Jiang, Shuai
AU  - Jiang S
AD  - Department of Aerospace Medicine, The Fourth Military Medical University, 169 
      Changle West Road, Xi'an 710032, China.
FAU - Hu, Wei
AU  - Hu W
AD  - Department of Biomedical Engineering, The Fourth Military Medical University, 169 
      Changle West Road, Xi'an 710032, China.
FAU - Li, Tian
AU  - Li T
AD  - Department of Biomedical Engineering, The Fourth Military Medical University, 169 
      Changle West Road, Xi'an 710032, China.
FAU - Di, Shouyin
AU  - Di S
AD  - Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical 
      University, 1 Xinsi Road, Xi'an 710038, China.
FAU - Wang, Dongjin
AU  - Wang D
AD  - Department of Thoracic and Cardiovascular Surgery, Affiliated Drum Tower Hospital 
      of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, 
      Jiangsu, China. Electronic address: dongjinwang210@163.com.
FAU - Yang, Yang
AU  - Yang Y
AD  - Department of Thoracic and Cardiovascular Surgery, Affiliated Drum Tower Hospital 
      of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, 
      Jiangsu, China; Department of Biomedical Engineering, The Fourth Military Medical 
      University, 169 Changle West Road, Xi'an 710032, China. Electronic address: 
      yang200214yy@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170406
PL  - England
TA  - Prog Lipid Res
JT  - Progress in lipid research
JID - 7900832
RN  - 0 (Forkhead Box Protein O1)
SB  - IM
MH  - Adipocytes/cytology/pathology
MH  - Animals
MH  - *Disease
MH  - Forkhead Box Protein O1/*metabolism
MH  - Gene Expression Regulation
MH  - Humans
MH  - *Lipid Metabolism
MH  - Lipolysis
OTO - NOTNLM
OT  - Forkhead box protein O1
OT  - Lipid metabolism
OT  - Lipid-related diseases
EDAT- 2017/04/11 06:00
MHDA- 2017/12/26 06:00
CRDT- 2017/04/11 06:00
PHST- 2016/11/04 00:00 [received]
PHST- 2017/03/29 00:00 [revised]
PHST- 2017/04/05 00:00 [accepted]
PHST- 2017/04/11 06:00 [pubmed]
PHST- 2017/12/26 06:00 [medline]
PHST- 2017/04/11 06:00 [entrez]
AID - S0163-7827(16)30048-0 [pii]
AID - 10.1016/j.plipres.2017.04.002 [doi]
PST - ppublish
SO  - Prog Lipid Res. 2017 Apr;66:42-49. doi: 10.1016/j.plipres.2017.04.002. Epub 2017 
      Apr 6.