PMID- 28392959
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2093-6966 (Print)
IS  - 2234-6856 (Electronic)
IS  - 2093-6966 (Linking)
VI  - 20
IP  - 1
DP  - 2017 Mar
TI  - Restricted Blood Flow Exercise in Sedentary, Overweight African-American Females 
      May Increase Muscle Strength and Decrease Endothelial Function and Vascular 
      Autoregulation.
PG  - 23-28
LID - 10.3831/KPI.2017.20.002 [doi]
AB  - OBJECTIVES: Exercise with partially restricted blood flow is a low-load, 
      low-intensity resistance training regimen which may have the potential to 
      increase muscle strength in the obese, elderly and frail who are unable to do 
      high-load training. Restricted blood flow exercise has also been shown to affect 
      blood vessel function variably and can, therefore, contribute to blood vessel 
      dysfunction. This pilot study tests the hypothesis that unilateral resistance 
      training of the leg extensors with partially restricted blood flow increases 
      muscle strength and decreases vascular autoregulation. METHODS: The subjects were 
      nine normotensive, overweight, young adult African-Americans with low 
      cardiorespiratory fitness who underwent unilateral training of the quadriceps' 
      femoris muscles with partially restricted blood flow at 30% of the 1-repetition 
      maximum (1-RM) load for 3 weeks. The 1-RM load and post-occlusion blood flow to 
      the lower leg (calf) were measured during reactive hyperemia. RESULTS: The 1-RM 
      load increased in the trained legs from 77 +/- 3 to 84 +/- 4 kg (P < 0.05) in the 
      absence of a significant effect on the 1-RM load in the contralateral untrained 
      legs (P > 0.1). Post-occlusion blood flow decreased significantly in the trained 
      legs from 19 +/- 2 to 13 +/- 2 mL. min(-1). dL(-1) (P < 0.05) and marginally in the 
      contralateral untrained legs from 18 +/- 2 to 16 +/- 1 mL. min(-1). dL(-1) (P = 
      0.09). Changes in post-occlusion blood flow to the skin overlying the trained and 
      the contralateral untrained muscles were not significant. CONCLUSION: These 
      results demonstrate that restricted blood flow exercise, which results in 
      significant gains in muscle strength, may produce decrements in endothelial 
      dysfunction and vascular autoregulation. Future studies should determine whether 
      pharmacopuncture plays a role in treatments for such blood vessel dysfunction.
FAU - Bond, Vernon
AU  - Bond V
AD  - Department of Recreation, Human Performance & Leisure Studies and Exercise 
      Science & Human Nutrition Laboratory, Howard University Cancer Centre, Washington 
      DC, United States of America.
FAU - Curry, Bryan Heath
AU  - Curry BH
AD  - Department of Medicine, Division of Cardiology, Howard College of Medicine & 
      Howard University Hospital, Washington DC, United States of America.
FAU - Kumar, Krishna
AU  - Kumar K
AD  - Department of Pharmaceutical Sciences, Howard University Hospital, Washington DC, 
      United States of America.
FAU - Pemminati, Sudhakar
AU  - Pemminati S
AD  - Department of Medical Pharmacology, AUA College of Medicine & Manipal University, 
      Antigua and Barbuda.
FAU - Gorantla, Vasavi Rakesh
AU  - Gorantla VR
AD  - Department of Behavioural Sciences and Neuroscience, AUA College of Medicine, 
      Antigua and Barbuda.
FAU - Kadur, Kishan
AU  - Kadur K
AD  - Department of Medical Physiology, AUA College of Medicine, Antigua and Barbuda.
FAU - Millis, Richard Mark
AU  - Millis RM
AD  - Department of Medical Physiology, AUA College of Medicine, Antigua and Barbuda.
LA  - eng
GR  - G12 MD007597/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PL  - Korea (South)
TA  - J Pharmacopuncture
JT  - Journal of pharmacopuncture
JID - 101572812
PMC - PMC5374335
OTO - NOTNLM
OT  - quadriceps femoris
OT  - resistance training
OT  - skeletal muscle
OT  - Kaatsu
COIS- Conflict of interest The authors declare that there are no conflicts of interest.
EDAT- 2017/04/11 06:00
MHDA- 2017/04/11 06:01
PMCR- 2017/03/01
CRDT- 2017/04/11 06:00
PHST- 2017/04/11 06:00 [entrez]
PHST- 2017/04/11 06:00 [pubmed]
PHST- 2017/04/11 06:01 [medline]
PHST- 2017/03/01 00:00 [pmc-release]
AID - 10.3831/KPI.2017.20.002 [doi]
PST - ppublish
SO  - J Pharmacopuncture. 2017 Mar;20(1):23-28. doi: 10.3831/KPI.2017.20.002.