PMID- 28393395
OWN - NLM
STAT- MEDLINE
DCOM- 20180514
LR  - 20210109
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 32
IP  - 1
DP  - 2018 Jan
TI  - Prevalence of hyperhomocysteinemia during routine physical examination in Guangxi 
      Province, China and related risk factors.
LID - 10.1002/jcla.22178 [doi]
LID - e22178
AB  - BACKGROUND: Studies on homocysteine (Hcy) have mainly focused on the correlation 
      between the homocysteine concentration and disease development. Few 
      epidemiological investigations have been performed. This study was conducted to 
      investigate the prevalence of hyperhomocysteinemia (HHcy) during routine physical 
      examination in Guangxi Province, China and the correlation of serum Hcy with 
      gender, age, serum uric acid (UA), total cholesterol (TC), triglycerides (TG), 
      high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol 
      (LDL-C), and blood glucose (GLU) to provide evidence for preventing and treating 
      HHcy. METHODS: Data of 8043 patients who underwent physical examinations at the 
      First Affiliated Hospital of Guangxi Medical University, China from 2015 to 2016 
      were collected. These data included gender, age, and the serum Hcy, UA, GLU, TC, 
      TG, HDL-C, and LDL-C concentrations. RESULTS: The overall prevalence of HHcy was 
      50.8% (52.3% in males, 48.1% in females). Age, UA, TC, TG, and LDL-C were 
      significantly higher and HDL-C was significantly lower in patients with than 
      without HHcy, regardless of gender (all P<.05). The Hcy level was positively 
      correlated with UA, TC, TG, and LDL-C but negatively correlated with HDL-C. 
      Gender, age, UA, TC, and TG were independent risk factors for HHcy. CONCLUSION: 
      The prevalence of HHcy was very high during routine physical examination in 
      Guangxi Province, China. HHcy was related to gender, age, high concentrations of 
      UA, TC, TG, and LDL-C; and low concentrations of HDL-C. Strengthening early 
      intervention of HHcy can reduce the risk of cardiovascular disease.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Qin, Yuan-Yuan
AU  - Qin YY
AD  - Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi 
      Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
FAU - Wang, Peng
AU  - Wang P
AD  - Department of Medical Center, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi Zhuang Autonomous Region, China.
FAU - Qin, Jin-Qiu
AU  - Qin JQ
AD  - Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi 
      Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
FAU - Wei, Ai-Qiu
AU  - Wei AQ
AD  - Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi 
      Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
FAU - Huang, Ping
AU  - Huang P
AD  - Department of Medical Center, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi Zhuang Autonomous Region, China.
FAU - Lai, Zhan-Feng
AU  - Lai ZF
AD  - Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi 
      Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
FAU - Lin, Fa-Quan
AU  - Lin FQ
AUID- ORCID: 0000-0002-8631-4339
AD  - Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi 
      Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
LA  - eng
PT  - Journal Article
DEP - 20170410
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 0 (Blood Glucose)
RN  - 0 (Lipids)
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/blood/*epidemiology
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Physical Examination
MH  - Prevalence
MH  - Risk Factors
MH  - Uric Acid/blood
MH  - Young Adult
PMC - PMC6817046
OTO - NOTNLM
OT  - blood glucose
OT  - blood lipid
OT  - homocysteine
OT  - hyperhomocysteinemia
OT  - uric acid
EDAT- 2017/04/11 06:00
MHDA- 2018/05/15 06:00
PMCR- 2017/04/10
CRDT- 2017/04/11 06:00
PHST- 2016/11/18 00:00 [received]
PHST- 2017/01/20 00:00 [accepted]
PHST- 2017/04/11 06:00 [pubmed]
PHST- 2018/05/15 06:00 [medline]
PHST- 2017/04/11 06:00 [entrez]
PHST- 2017/04/10 00:00 [pmc-release]
AID - JCLA22178 [pii]
AID - 10.1002/jcla.22178 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2018 Jan;32(1):e22178. doi: 10.1002/jcla.22178. Epub 2017 Apr 
      10.