PMID- 28394496
OWN - NLM
STAT- MEDLINE
DCOM- 20170918
LR  - 20170918
IS  - 1757-5672 (Electronic)
IS  - 1757-5664 (Linking)
VI  - 9
IP  - 2
DP  - 2017 May
TI  - Change of Ultrasound Estimated Bladder Weight and Bladder Wall Thickness After 
      Treatment of Bladder Outlet Obstruction With Dutasteride.
PG  - 67-74
LID - 10.1111/luts.12110 [doi]
AB  - OBJECTIVES: To investigate the change of bladder wall hypertrophy to relieve 
      bladder outlet obstruction (BOO) by treatment with 5alpha-reductase inhibitor. 
      METHODS: Men who have BOO confirmed by urodynamic study (BOO index >/=40) were 
      treated with dutasteride 0.5 mg once a day for 6 months. We measured ultrasound 
      estimated bladder weight (UEBW), UEBW divided by body surface area (UEBW/BSA), 
      and bladder wall thickness (BWT) before and after treatment. Changes in LUTS 
      parameters were assessed by using the International Prostate Symptom Score, 
      uroflowmetry, residual urine volume, prostate volume, serum prostate-specific 
      antigen (PSA), and LUTS outcome scores (LOS). Correlation between the change of 
      LUTS parameters and UEBW, UEBW/BSA, and BWT were evaluated. We assessed the 
      changes of bladder wall hypertrophy according to the results of benefit, 
      satisfaction, and willingness to continue (BSW) questionnaire. RESULTS: Thirty 
      patients completed the 6-month study. The mean UEBW was 47.10 +/- 7.79 g before and 
      50.07 +/- 5.39 g after dutasteride treatment (P = 0.259). The mean UEBW/BSA was 
      26.47 +/- 4.30 g/m(2) before and 28.2 +/- 3.53 g/m(2) after treatment (P = 0.253), 
      and there was no definite change in mean BWT after treatment (P = 0.301). Most 
      LUTS parameters including LOS significantly improved. Increased BOO index value 
      was related to decreased BWT (rho = 0.361, P = 0.049). There was no definite change 
      in mean UEBW, UEBW/BSA, and BWT according to the results of the BSW 
      questionnaire. CONCLUSIONS: There was no change in UEBW, UEBW/BSA and BWT despite 
      improving most clinical parameters suggesting BOO. The changes of bladder wall 
      hypertrophy parameters still have limitations to directly reflect the relief of 
      BOO.
CI  - (c) 2015 Wiley Publishing Asia Pty Ltd.
FAU - Lee, Ha Na
AU  - Lee HN
AD  - Department of Urology, Seoul Seonam Hospital, Ewha Womans University, Seoul, 
      Korea.
FAU - Lee, Young-Suk
AU  - Lee YS
AD  - Department of Urology, Samsung Changwon Hospital, Sungkyunkwan University School 
      of Medicine, Changwon, Korea.
FAU - Han, Deok Hyun
AU  - Han DH
AD  - Department of Urology, Samsung Medical Center, Sungkyunkwan University School of 
      Medicine, Seoul, Korea.
FAU - Lee, Kyu-Sung
AU  - Lee KS
AD  - Department of Urology, Samsung Medical Center, Sungkyunkwan University School of 
      Medicine, Seoul, Korea.
AD  - Department of Medical Device Management and Research, SAIHST, Sungkyunkwan 
      University, , Seoul, Korea.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20150727
PL  - Australia
TA  - Low Urin Tract Symptoms
JT  - Lower urinary tract symptoms
JID - 101506777
RN  - 0 (5-alpha Reductase Inhibitors)
RN  - O0J6XJN02I (Dutasteride)
SB  - IM
MH  - 5-alpha Reductase Inhibitors/*therapeutic use
MH  - Aged
MH  - Aged, 80 and over
MH  - Dutasteride/*therapeutic use
MH  - Humans
MH  - Lower Urinary Tract Symptoms/diagnostic imaging/drug therapy
MH  - Male
MH  - Middle Aged
MH  - Organ Size
MH  - Prospective Studies
MH  - Prostatic Hyperplasia/diagnostic imaging/surgery
MH  - Treatment Outcome
MH  - Ultrasonography
MH  - Urinary Bladder/*pathology
MH  - Urinary Bladder Neck Obstruction/diagnostic imaging/*drug therapy/pathology
OTO - NOTNLM
OT  - 5alpha-reductase inhibitor
OT  - bladder outlet obstruction
OT  - bladder wall thickness
OT  - lower urinary tract symptom
OT  - ultrasound estimated bladder weight
EDAT- 2017/04/11 06:00
MHDA- 2017/09/19 06:00
CRDT- 2017/04/11 06:00
PHST- 2015/03/30 00:00 [received]
PHST- 2015/05/30 00:00 [revised]
PHST- 2015/06/14 00:00 [accepted]
PHST- 2017/04/11 06:00 [entrez]
PHST- 2017/04/11 06:00 [pubmed]
PHST- 2017/09/19 06:00 [medline]
AID - 10.1111/luts.12110 [doi]
PST - ppublish
SO  - Low Urin Tract Symptoms. 2017 May;9(2):67-74. doi: 10.1111/luts.12110. Epub 2015 
      Jul 27.