PMID- 28395808
OWN - NLM
STAT- MEDLINE
DCOM- 20171122
LR  - 20211204
IS  - 1876-7753 (Electronic)
IS  - 1873-5061 (Linking)
VI  - 18
DP  - 2017 Jan
TI  - Generation of non-integrated induced pluripotent stem cells from a 59-year-old 
      female with multiple endocrine neoplasia type 1 syndrome.
PG  - 64-66
LID - S1873-5061(16)30203-3 [pii]
LID - 10.1016/j.scr.2016.12.009 [doi]
AB  - Urine resource cells were collected from a 59-year-old female patient with 
      multiple endocrine neoplasia type 1 syndrome (MEN1) for generating iPS cells with 
      episomal plasmids carrying Oct4, Sox2, Klf4 and miR-302-367. The patient 
      sustained a heterozygous G>T transition mutation on the exon 9 of Men1 gene that 
      was confirmed by sequencing analysis on the obtained iPSC lines. Karyotyping 
      indicated the chromosomes with normal appearances and numbers. Their pluripotency 
      was demonstrated by gene expression, as well as their abilities for 
      differentiating into three germ layers. This cell line provides an ideal model 
      for studying MEN1.
CI  - Copyright (c) 2016 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Guo, Dongsheng
AU  - Guo D
AD  - Institute of Public Health, Guangzhou Institutes of Biomedicine and Health, 
      Chinese Academy of Sciences, Guangzhou, China; South China Institute for Stem 
      Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and 
      Health, Chinese Academy of Sciences, Guangzhou, China.
FAU - Wu, Feima
AU  - Wu F
AD  - Institute of Public Health, Guangzhou Institutes of Biomedicine and Health, 
      Chinese Academy of Sciences, Guangzhou, China; South China Institute for Stem 
      Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and 
      Health, Chinese Academy of Sciences, Guangzhou, China.
FAU - Liu, Haikun
AU  - Liu H
AD  - Institute of Public Health, Guangzhou Institutes of Biomedicine and Health, 
      Chinese Academy of Sciences, Guangzhou, China; South China Institute for Stem 
      Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and 
      Health, Chinese Academy of Sciences, Guangzhou, China.
FAU - Gao, Ge
AU  - Gao G
AD  - Institute of Public Health, Guangzhou Institutes of Biomedicine and Health, 
      Chinese Academy of Sciences, Guangzhou, China; South China Institute for Stem 
      Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and 
      Health, Chinese Academy of Sciences, Guangzhou, China.
FAU - Kou, Shanglong
AU  - Kou S
AD  - Institute of Public Health, Guangzhou Institutes of Biomedicine and Health, 
      Chinese Academy of Sciences, Guangzhou, China; South China Institute for Stem 
      Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and 
      Health, Chinese Academy of Sciences, Guangzhou, China.
FAU - Yang, Fan
AU  - Yang F
AD  - Institute of Public Health, Guangzhou Institutes of Biomedicine and Health, 
      Chinese Academy of Sciences, Guangzhou, China; South China Institute for Stem 
      Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and 
      Health, Chinese Academy of Sciences, Guangzhou, China.
FAU - Abbas, Nasir
AU  - Abbas N
AD  - Institute of Public Health, Guangzhou Institutes of Biomedicine and Health, 
      Chinese Academy of Sciences, Guangzhou, China; South China Institute for Stem 
      Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and 
      Health, Chinese Academy of Sciences, Guangzhou, China.
FAU - Zhou, Tiancheng
AU  - Zhou T
AD  - South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou 
      Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 
      China.
FAU - Cai, Xiujuan
AU  - Cai X
AD  - South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou 
      Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 
      China.
FAU - Zhang, Hui
AU  - Zhang H
AD  - South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou 
      Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 
      China.
FAU - Qin, Dajiang
AU  - Qin D
AD  - South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou 
      Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 
      China.
FAU - Li, Jialiang
AU  - Li J
AD  - Guangzhou Fuda Cancer Hospital, Guangzhou City, Guangdong Province, China.
FAU - Xu, Kecheng
AU  - Xu K
AD  - Guangzhou Fuda Cancer Hospital, Guangzhou City, Guangdong Province, China. 
      Electronic address: xukc@vip.163.com.
FAU - Li, Yin-Xiong
AU  - Li YX
AD  - Institute of Public Health, Guangzhou Institutes of Biomedicine and Health, 
      Chinese Academy of Sciences, Guangzhou, China; South China Institute for Stem 
      Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and 
      Health, Chinese Academy of Sciences, Guangzhou, China; Guangdong Provincial Key 
      Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, 
      Chinese Academy of Sciences, Guangzhou, China. Electronic address: 
      li_yinxiong@gibh.ac.cn.
LA  - eng
PT  - Journal Article
DEP - 20161209
PL  - England
TA  - Stem Cell Res
JT  - Stem cell research
JID - 101316957
RN  - 0 (KLF4 protein, human)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Base Sequence
MH  - Cell Culture Techniques/methods
MH  - Cell Differentiation
MH  - Cell Line
MH  - *Cellular Reprogramming
MH  - DNA Mutational Analysis
MH  - Embryoid Bodies/metabolism/pathology
MH  - Exons
MH  - Female
MH  - Heterozygote
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology/metabolism/transplantation
MH  - Karyotype
MH  - Kruppel-Like Factor 4
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/genetics/metabolism/*pathology
MH  - Polymorphism, Single Nucleotide
MH  - Proto-Oncogene Proteins/*genetics
MH  - Transcription Factors/genetics/metabolism
MH  - Urine/cytology
EDAT- 2017/04/12 06:00
MHDA- 2017/11/29 06:00
CRDT- 2017/04/12 06:00
PHST- 2016/11/04 00:00 [received]
PHST- 2016/12/05 00:00 [accepted]
PHST- 2017/04/12 06:00 [entrez]
PHST- 2017/04/12 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
AID - S1873-5061(16)30203-3 [pii]
AID - 10.1016/j.scr.2016.12.009 [doi]
PST - ppublish
SO  - Stem Cell Res. 2017 Jan;18:64-66. doi: 10.1016/j.scr.2016.12.009. Epub 2016 Dec 
      9.