PMID- 28396009
OWN - NLM
STAT- MEDLINE
DCOM- 20180322
LR  - 20181005
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1665
DP  - 2017 Jun 15
TI  - Molecular mechanisms of brain-derived neurotrophic factor in neuro-protection: 
      Recent developments.
PG  - 1-21
LID - S0006-8993(17)30144-0 [pii]
LID - 10.1016/j.brainres.2017.03.029 [doi]
AB  - Neuronal cell injury, as a consequence of acute or chronic neurological trauma, 
      is a significant cause of mortality around the world. On a molecular level, the 
      condition is characterized by widespread cell death and poor regeneration, which 
      can result in severe morbidity in survivors. Potential therapeutics are of major 
      interest, with a promising candidate being brain-derived neurotrophic factor 
      (BDNF), a ubiquitous agent in the brain which has been associated with neural 
      development and may facilitate protective and regenerative effects following 
      injury. This review summarizes the available information on the potential 
      benefits of BDNF and the molecular mechanisms involved in several pathological 
      conditions, including hypoxic brain injury, stroke, Alzheimer's disease and 
      Parkinson's disease. It further explores the methods in which BDNF can be applied 
      in clinical and therapeutic settings, and the potential challenges to overcome.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Zhao, Hailin
AU  - Zhao H
AD  - Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, 
      Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, 
      London, UK.
FAU - Alam, Azeem
AU  - Alam A
AD  - Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, 
      Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, 
      London, UK.
FAU - San, Chun-Yin
AU  - San CY
AD  - Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, 
      Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, 
      London, UK.
FAU - Eguchi, Shiori
AU  - Eguchi S
AD  - Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, 
      Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, 
      London, UK.
FAU - Chen, Qian
AU  - Chen Q
AD  - Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, 
      Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, 
      London, UK; Department of Anaesthesiology, Southwest Hospital, Third Military 
      Medical University, Chongqing, China.
FAU - Lian, Qingquan
AU  - Lian Q
AD  - Department of Anesthesiology, Second Affiliated Hospital, Wenzhou Medical 
      University, Wenzhou, China. Electronic address: lianqingquanmz@163.com.
FAU - Ma, Daqing
AU  - Ma D
AD  - Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, 
      Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, 
      London, UK. Electronic address: d.ma@imperial.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170407
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Alzheimer Disease/*metabolism/therapy
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Humans
MH  - Hypoxia, Brain/metabolism/therapy
MH  - Neurons/*metabolism
MH  - Parkinson Disease/metabolism/therapy
OTO - NOTNLM
OT  - Brain injury
OT  - Brain-derived neurotrophic factor
OT  - Neuroprotection
EDAT- 2017/04/12 06:00
MHDA- 2018/03/23 06:00
CRDT- 2017/04/12 06:00
PHST- 2016/10/19 00:00 [received]
PHST- 2017/03/02 00:00 [revised]
PHST- 2017/03/28 00:00 [accepted]
PHST- 2017/04/12 06:00 [pubmed]
PHST- 2018/03/23 06:00 [medline]
PHST- 2017/04/12 06:00 [entrez]
AID - S0006-8993(17)30144-0 [pii]
AID - 10.1016/j.brainres.2017.03.029 [doi]
PST - ppublish
SO  - Brain Res. 2017 Jun 15;1665:1-21. doi: 10.1016/j.brainres.2017.03.029. Epub 2017 
      Apr 7.