PMID- 28396037
OWN - NLM
STAT- MEDLINE
DCOM- 20180124
LR  - 20240326
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 94
DP  - 2017 Jun
TI  - Antecedents and correlates of blood concentrations of neurotrophic growth factors 
      in very preterm newborns.
PG  - 21-28
LID - S1043-4666(17)30074-1 [pii]
LID - 10.1016/j.cyto.2017.03.012 [doi]
AB  - AIM: To identify the antecedents and very early correlates of low concentrations 
      of neurotrophic growth factors in the blood of extremely preterm newborns during 
      the first postnatal month. METHODS: Using an immunobead assay, we measured the 
      concentrations of neurotrophin 4 (NT4), brain-derived neurotrophic factor (BDNF), 
      and basic fibroblast growth factor (bFGF) in blood spots collected on postnatal 
      days 1 (N=1062), 7 (N=1087), 14 (N=989), 21 (N=940) and 28 (N=880) from infants 
      born before the 28th week of gestation. We then sought the correlates of 
      measurements in the top and bottom quartiles for gestational age and day the 
      specimen was collected. RESULTS: The concentrations of 2 neurotrophic proteins, 
      NT4 and BDNF, were low among children delivered for medical (maternal or fetal) 
      indications, and among those who were growth restricted. Children who had top 
      quartile concentrations of NT4, BDNF, and bFGF tended to have elevated 
      concentrations of inflammation-related proteins that day. This pattern persisted 
      for much of the first postnatal month. CONCLUSIONS: Delivery for medical 
      indications and fetal growth restriction are associated with a relative paucity 
      of NT4 and BDNF concentrations during the first 24 h after very preterm birth. 
      Elevated blood concentrations of NT4, BDNF, and bFGF tended to co-occur with 
      indicators of systemic inflammation on the same day.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Leviton, Alan
AU  - Leviton A
AD  - Boston Children's Hospital, and Harvard Medical School, Boston, MA, United 
      States. Electronic address: alan.leviton@childrens.harvard.edu.
FAU - Allred, Elizabeth N
AU  - Allred EN
AD  - Boston Children's Hospital, and Harvard Medical School, Boston, MA, United 
      States.
FAU - Yamamoto, Hidemi
AU  - Yamamoto H
AD  - Brigham and Women's Hospital, Boston, MA, United States.
FAU - Fichorova, Raina N
AU  - Fichorova RN
AD  - Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United 
      States.
FAU - Kuban, Karl
AU  - Kuban K
AD  - Boston Medical Center and Boston University, Boston, MA, United States.
FAU - O'Shea, T Michael
AU  - O'Shea TM
AD  - University of North Carolina, Chapel Hill, NC, United States.
FAU - Dammann, Olaf
AU  - Dammann O
AD  - Tufts University School of Medicine, Boston, MA, United States; Hannover Medical 
      School, Hannover, Germany.
CN  - ELGAN Study Investigators
LA  - eng
GR  - P30 HD018655/HD/NICHD NIH HHS/United States
GR  - R01 EY021820/EY/NEI NIH HHS/United States
GR  - U01 NS040069/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
DEP - 20170407
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (Nerve Growth Factors)
RN  - 62031-54-3 (Fibroblast Growth Factors)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cytokines/blood
MH  - Female
MH  - *Fetal Development
MH  - Fetus/physiology
MH  - Fibroblast Growth Factors/*blood
MH  - Gestational Age
MH  - Humans
MH  - Infant, Extremely Premature/*blood
MH  - Infant, Newborn
MH  - Inflammation/*blood
MH  - Neovascularization, Physiologic
MH  - Nerve Growth Factors/*blood
MH  - Prospective Studies
PMC - PMC5464409
MID - NIHMS866910
OTO - NOTNLM
OT  - Angiogenesis
OT  - Cytokines
OT  - Infant, newborn
OT  - Infant, premature/blood
OT  - Inflammation
OT  - Neurotrophic factors
EDAT- 2017/04/12 06:00
MHDA- 2018/01/25 06:00
PMCR- 2018/06/01
CRDT- 2017/04/12 06:00
PHST- 2016/10/05 00:00 [received]
PHST- 2017/01/18 00:00 [revised]
PHST- 2017/03/31 00:00 [accepted]
PHST- 2017/04/12 06:00 [pubmed]
PHST- 2018/01/25 06:00 [medline]
PHST- 2017/04/12 06:00 [entrez]
PHST- 2018/06/01 00:00 [pmc-release]
AID - S1043-4666(17)30074-1 [pii]
AID - 10.1016/j.cyto.2017.03.012 [doi]
PST - ppublish
SO  - Cytokine. 2017 Jun;94:21-28. doi: 10.1016/j.cyto.2017.03.012. Epub 2017 Apr 7.