PMID- 2839686
OWN - NLM
STAT- MEDLINE
DCOM- 19880819
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 62
IP  - 8
DP  - 1988 Aug
TI  - Biological characterization of a simian immunodeficiency virus-like retrovirus 
      (HTLV-IV): evidence for CD4-associated molecules required for infection.
PG  - 2557-68
AB  - We have analyzed a number of biological features of HTLV-IV, a retrovirus 
      indistinguishable from a macaque isolate of simian immunodeficiency virus (SIV), 
      and compared this virus with several strains of human immunodeficiency virus type 
      1 (HIV-1). Although HTLV-IV was found to be similar to HIV-1 in its tropism for 
      CD4+ lymphocytes, its effects on CD4 expression and the ability of its 
      externalized envelope molecule to form a complex directly with the CD4 molecule, 
      a number of striking differences were noted. Unlike with HIV-1, the range of 
      cells susceptible to HTLV-IV infection and syncytia formation was restricted to a 
      subset of CD4+ cell lines, particularly those that coexpressed CD4 with human 
      leukocyte antigen (HLA) class II antigens. An analysis of the patterns of HTLV-IV 
      infection with B x T somatic cell hybrids indicated that for this virus, 
      molecules in addition to CD4 were probably required to facilitate infection and 
      cell fusion. Additional studies of HTLV-IV infection of Sup-T1 cells, which are 
      exquisitely sensitive to cytopathic effects induced by HIV-1, demonstrated that 
      HTLV-IV infection could occur in the absence of cytopathic effects and, 
      remarkably, with minimal or no downmodulation of the CD4 molecule from the cell 
      surface. The failure of HTLV-IV infection to reduce the expression of several CD4 
      epitopes suggested that the HTLV-IV envelope produced by Sup-T1 cells was altered 
      in its ability to interact with or bind to CD4. Additional differences were also 
      noted in the size of the transmembrane envelope molecule of HTLV-IV produced by 
      Sup-T1 cells, indicating that cell-specific alterations in processing of the 
      HTLV-IV envelope occurred during the production of virus in this cell line. 
      Understanding the basis for these biological differences between HTLV-IV and the 
      HIV-1 viruses may help to elucidate more general mechanisms for pathogenesis of 
      other members of the SIV and HIV families of retroviruses.
FAU - Hoxie, J A
AU  - Hoxie JA
AD  - Hematology-Oncology Section, Hospital of the University of Pennsylvania, 
      Philadelphia 19104.
FAU - Haggarty, B S
AU  - Haggarty BS
FAU - Bonser, S E
AU  - Bonser SE
FAU - Rackowski, J L
AU  - Rackowski JL
FAU - Shan, H
AU  - Shan H
FAU - Kanki, P J
AU  - Kanki PJ
LA  - eng
GR  - P01 A125380-01/PHS HHS/United States
GR  - UO1 A12360-01/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (HLA-D Antigens)
RN  - 0 (Receptors, Virus)
RN  - 0 (Viral Envelope Proteins)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/immunology
MH  - Antigens, Differentiation, T-Lymphocyte/*physiology
MH  - Cell Fusion
MH  - Cell Line
MH  - Cytopathogenic Effect, Viral
MH  - Deltaretrovirus/*physiology
MH  - HIV/physiology
MH  - HLA-D Antigens/analysis
MH  - Haplorhini/microbiology
MH  - Humans
MH  - Receptors, Virus/*physiology
MH  - Species Specificity
MH  - T-Lymphocytes/*microbiology
MH  - Viral Envelope Proteins/physiology
MH  - Virus Replication
PMC - PMC253685
EDAT- 1988/08/01 00:00
MHDA- 1988/08/01 00:01
PMCR- 1988/08/01
CRDT- 1988/08/01 00:00
PHST- 1988/08/01 00:00 [pubmed]
PHST- 1988/08/01 00:01 [medline]
PHST- 1988/08/01 00:00 [entrez]
PHST- 1988/08/01 00:00 [pmc-release]
AID - 10.1128/JVI.62.8.2557-2568.1988 [doi]
PST - ppublish
SO  - J Virol. 1988 Aug;62(8):2557-68. doi: 10.1128/JVI.62.8.2557-2568.1988.