PMID- 28397050
OWN - NLM
STAT- MEDLINE
DCOM- 20170613
LR  - 20181113
IS  - 1993-1352 (Electronic)
IS  - 1672-0733 (Linking)
VI  - 37
IP  - 2
DP  - 2017 Apr
TI  - Waist circumference-dependent peripheral monocytes change after gliclazide 
      treatment for Chinese type 2 diabetic patients.
PG  - 204-209
LID - 10.1007/s11596-017-1716-x [doi]
AB  - Gliclazide used for the treatment of type 2 diabetes mellitus (T2DM) stimulates 
      insulin secretion and influences peripheral blood monocytes. The roles of 
      gliclazide in peripheral monocytes of newly diagnosed T2DM patients were 
      investigated in this study. A total of 105 newly diagnosed T2DM patients with no 
      history of antihyperglycemic medication were treated with gliclazide-modified 
      release for 16 weeks. The total and differential leukocyte profiles of peripheral 
      blood were measured at baseline and week 16. The peripheral blood monocyte count 
      at week 16 was significantly lower than that at baseline (P=0.019). Peripheral 
      monocytes level at baseline was positively correlated with waist circumference. 
      After gliclazide treatment, the peripheral monocytes were decreased 
      [(320.09+/-15.13)x10(6)/L vs. (294.19+/-14.22)x10(6)/L] in non-abdominal obesity 
      group, but increased in abdominal obesity group [(344.36+/-17.24)x10(6)/L vs. 
      (351.87+/-16.93)x10(6)/L]. Compared with non-abdominal obese patients, abdominal 
      obese patients showed higher Deltamonocytes (P=0.046) and Deltaacute insulin secretion 
      (P=0.049), but lower DeltaHbA1c (P=0.047). There was significantly positive 
      correlation between Deltamonocytes and Deltaacute insulin secretion (P=0.015), which 
      disappeared after adjusting for age, waist circumference and dosage at baseline. 
      In conclusion, waist circumference is correlated with peripheral monocyte change 
      after gliclazide treatment in Chinese newly diagnosed T2DM patients. Peripheral 
      monocytes are decreased in non-abdominal obesity group and increased in abdominal 
      obesity group after gliclazide treatment.
FAU - Li, Qing
AU  - Li Q
AD  - Department of Endocrinology & Metabolism, Shanghai Clinical Center of Diabetes, 
      Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 
      200233, China.
FAU - Yu, Hao-Yong
AU  - Yu HY
AD  - Department of Endocrinology & Metabolism, Shanghai Clinical Center of Diabetes, 
      Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 
      200233, China.
FAU - Chen, Miao
AU  - Chen M
AD  - Department of Endocrinology & Metabolism, Shanghai Clinical Center of Diabetes, 
      Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 
      200233, China.
FAU - Jiang, Feng
AU  - Jiang F
AD  - Department of Endocrinology & Metabolism, Shanghai Clinical Center of Diabetes, 
      Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 
      200233, China.
FAU - Zhou, Jian
AU  - Zhou J
AD  - Department of Endocrinology & Metabolism, Shanghai Clinical Center of Diabetes, 
      Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 
      200233, China.
FAU - Bao, Yu-Qian
AU  - Bao YQ
AD  - Department of Endocrinology & Metabolism, Shanghai Clinical Center of Diabetes, 
      Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 
      200233, China.
FAU - Hu, Cheng
AU  - Hu C
AD  - Department of Endocrinology & Metabolism, Shanghai Clinical Center of Diabetes, 
      Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 
      200233, China. alfredhc@sjtu.edu.cn.
FAU - Jia, Wei-Ping
AU  - Jia WP
AD  - Department of Endocrinology & Metabolism, Shanghai Clinical Center of Diabetes, 
      Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 
      200233, China. wpjia@sjtu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170411
PL  - China
TA  - J Huazhong Univ Sci Technolog Med Sci
JT  - Journal of Huazhong University of Science and Technology. Medical sciences = Hua 
      zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. 
      Yixue Yingdewen ban
JID - 101169627
RN  - 0 (Hypoglycemic Agents)
RN  - G4PX8C4HKV (Gliclazide)
SB  - IM
MH  - China
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy
MH  - Drug Administration Schedule
MH  - Female
MH  - Gliclazide/*administration & dosage/pharmacology
MH  - Humans
MH  - Hypoglycemic Agents/*administration & dosage/pharmacology
MH  - Leukocyte Count
MH  - Leukocytes, Mononuclear/*cytology/drug effects
MH  - Male
MH  - Middle Aged
MH  - Obesity, Abdominal/blood
MH  - Waist Circumference/drug effects
OTO - NOTNLM
OT  - gliclazide
OT  - monocytes
OT  - obesity
OT  - type 2 diabetes
OT  - waist
EDAT- 2017/04/12 06:00
MHDA- 2017/06/14 06:00
CRDT- 2017/04/12 06:00
PHST- 2016/05/09 00:00 [received]
PHST- 2017/02/17 00:00 [revised]
PHST- 2017/04/12 06:00 [entrez]
PHST- 2017/04/12 06:00 [pubmed]
PHST- 2017/06/14 06:00 [medline]
AID - 10.1007/s11596-017-1716-x [pii]
AID - 10.1007/s11596-017-1716-x [doi]
PST - ppublish
SO  - J Huazhong Univ Sci Technolog Med Sci. 2017 Apr;37(2):204-209. doi: 
      10.1007/s11596-017-1716-x. Epub 2017 Apr 11.