PMID- 28397057
OWN - NLM
STAT- MEDLINE
DCOM- 20170613
LR  - 20220801
IS  - 1993-1352 (Electronic)
IS  - 1672-0733 (Linking)
VI  - 37
IP  - 2
DP  - 2017 Apr
TI  - Clinical application analysis of andrographolide total ester sulfonate injection, 
      a traditional Chinese medicine licensed in China.
PG  - 293-299
LID - 10.1007/s11596-017-1730-z [doi]
AB  - Andrographolide total ester sulfonate (ATES) injection is one of the products of 
      traditional Chinese medicine (TCM) currently used against viral infection in 
      China. ATES injection was approved for manufacturing and marketing in January 
      2002. It is indicated for acute respiratory infections, tonsillitis, chronic 
      obstructive pulmonary disease, influenza, foot and mouth disease, bronchiolitis, 
      herpangina, mumps, infectious mononucleosis and psychosis. However, its usage 
      also carries risk. We investigated the use of ATES at the Wuhan Union Hospital 
      from January 2014 to December 2014 and evaluated its real-world clinical 
      application using the hospital centralized monitoring method. A total of 848 
      cases were enrolled in this study. In these cases, it was mainly used for 
      postoperative anti-inflammation and treating upper respiratory infection, 
      pneumonia and bronchitis. Among them, 39.86% were contraindicated. Irregular 
      medication of adults and children accounted for 1.91% and 23.38%, respectively. 
      Improper choice of solvent accounted for 3.18%. The choice of intravenous drip 
      versus aerosol inhalation was reasonable. A case of adverse events (AEs) was 
      observed in the monitoring period, and the incidence of adverse drug reaction 
      (ADR) of ATES injection was 0.12%. ATES injection in our hospital is relatively 
      safe with a low incidence of adverse reactions. The study assesses the clinical 
      usage and adverse reactions of ATES injection, and provides suggestions for 
      rational use in clinical practice.
FAU - Zhao, Ying
AU  - Zhao Y
AD  - Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Huang, Pu
AU  - Huang P
AD  - Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Chen, Zhe
AU  - Chen Z
AD  - Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Zheng, Si-Wei
AU  - Zheng SW
AD  - Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Yu, Jin-Yang
AU  - Yu JY
AD  - Center for ADR Monitoring of Guangdong, Guangzhou, 510000, China.
FAU - Shi, Chen
AU  - Shi C
AD  - Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China. 29136909@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20170411
PL  - China
TA  - J Huazhong Univ Sci Technolog Med Sci
JT  - Journal of Huazhong University of Science and Technology. Medical sciences = Hua 
      zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. 
      Yixue Yingdewen ban
JID - 101169627
RN  - 0 (Diterpenes)
RN  - 410105JHGR (andrographolide)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Diterpenes/*administration & dosage/adverse effects
MH  - Drug Utilization
MH  - Female
MH  - Hospitals
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Injections
MH  - Male
MH  - Medicine, Chinese Traditional
MH  - Middle Aged
MH  - Respiratory Tract Infections/*drug therapy
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - adverse reaction
OT  - andrographolide total ester sulfonate
OT  - clinical use
OT  - hospital centralized monitoring
OT  - post-marketing reassessment
EDAT- 2017/04/12 06:00
MHDA- 2017/06/14 06:00
CRDT- 2017/04/12 06:00
PHST- 2016/04/06 00:00 [received]
PHST- 2016/10/26 00:00 [revised]
PHST- 2017/04/12 06:00 [entrez]
PHST- 2017/04/12 06:00 [pubmed]
PHST- 2017/06/14 06:00 [medline]
AID - 10.1007/s11596-017-1730-z [pii]
AID - 10.1007/s11596-017-1730-z [doi]
PST - ppublish
SO  - J Huazhong Univ Sci Technolog Med Sci. 2017 Apr;37(2):293-299. doi: 
      10.1007/s11596-017-1730-z. Epub 2017 Apr 11.