PMID- 28397071
OWN - NLM
STAT- MEDLINE
DCOM- 20180419
LR  - 20181202
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 42
IP  - 8
DP  - 2017 Aug
TI  - Taurine Promotes the Cartilaginous Differentiation of Human Umbilical 
      Cord-Derived Mesenchymal Stem Cells in Vitro.
PG  - 2344-2353
LID - 10.1007/s11064-017-2252-6 [doi]
AB  - Taurine has been reported to influence osteogenic differentiation, but the role 
      of taurine on cartilaginous differentiation using human umbilical cord-derived 
      mesenchymal stem cells (hUC-MSCs) remains unclear. In this study, we investigated 
      the effect of taurine (0, 1, 5 and 10 mM) on the proliferation and chondrogenesis 
      of hUC-MSCs by analyzing cell proliferation, accumulation of glycosaminoglycans 
      and expression of cartilage specific mRNA. The results show though taurine did 
      not affected the proliferation of hUC-MSCs, 5 mM of taurine is sufficient to 
      enhanced the accumulation of glycosaminoglycans and up-regulate cartilage 
      specific mRNA expression, namely collagen type II, aggrecan and SOX9. Taurine 
      also inhibits chondrocyte dedifferentiation by reducing expression of collagen 
      type I mRNA. Taken together, our study reveals that taurine promotes and 
      maintains the chondrogenesis of hUC-MSCs.
FAU - Yao, Xiuhua
AU  - Yao X
AD  - Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, 
      Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, No. 6, JiZhao Road, 
      Hexi district, Tianjin, 300350, People's Republic of China.
FAU - Huang, Huiling
AU  - Huang H
AD  - Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, 
      Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, No. 6, JiZhao Road, 
      Hexi district, Tianjin, 300350, People's Republic of China. huanghuiling@126.com.
FAU - Li, Zhou
AU  - Li Z
AD  - NewScen Coast Bio-Pharmaceutical Co., Ltd., 65 sixth Ave., TEDA, Tianjin, 300457, 
      People's Republic of China.
FAU - Liu, Xiaohua
AU  - Liu X
AD  - Arthro-Anda Tianjin Biologic Technology Co., Ltd., 2F Building No. 2, Tian Bao 
      Industrial Park, Xi Qi Road, Tianjin Airport Industrial Park, Tianjin, 300308, 
      People's Republic of China.
FAU - Fan, Weijia
AU  - Fan W
AD  - Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, 
      Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, No. 6, JiZhao Road, 
      Hexi district, Tianjin, 300350, People's Republic of China.
FAU - Wang, Xinping
AU  - Wang X
AD  - Departement of Neurology, Tianjin Huanhu Hospital, No. 6, JiZhao Road, Hexi 
      district, Tianjin, 300350, People's Republic of China.
FAU - Sun, Xuelian
AU  - Sun X
AD  - Arthro-Anda Tianjin Biologic Technology Co., Ltd., 2F Building No. 2, Tian Bao 
      Industrial Park, Xi Qi Road, Tianjin Airport Industrial Park, Tianjin, 300308, 
      People's Republic of China.
FAU - Zhu, Jianmin
AU  - Zhu J
AD  - Arthro-Anda Tianjin Biologic Technology Co., Ltd., 2F Building No. 2, Tian Bao 
      Industrial Park, Xi Qi Road, Tianjin Airport Industrial Park, Tianjin, 300308, 
      People's Republic of China.
FAU - Zhou, Hongrui
AU  - Zhou H
AD  - NewScen Coast Bio-Pharmaceutical Co., Ltd., 65 sixth Ave., TEDA, Tianjin, 300457, 
      People's Republic of China.
FAU - Wei, Huaying
AU  - Wei H
AD  - Arthro-Anda Tianjin Biologic Technology Co., Ltd., 2F Building No. 2, Tian Bao 
      Industrial Park, Xi Qi Road, Tianjin Airport Industrial Park, Tianjin, 300308, 
      People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20170410
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 1EQV5MLY3D (Taurine)
SB  - IM
MH  - Cell Proliferation/drug effects/physiology
MH  - Cells, Cultured
MH  - Chondrogenesis/drug effects/*physiology
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Mesenchymal Stem Cells/drug effects/*physiology
MH  - Osteogenesis/drug effects/physiology
MH  - Taurine/*pharmacology
MH  - Umbilical Cord/*cytology/drug effects/*physiology
OTO - NOTNLM
OT  - Chondrogenesis
OT  - Human mesenchymal stem cells
OT  - Taurine
OT  - Umbilical cord
EDAT- 2017/04/12 06:00
MHDA- 2018/04/20 06:00
CRDT- 2017/04/12 06:00
PHST- 2016/11/14 00:00 [received]
PHST- 2017/03/29 00:00 [accepted]
PHST- 2017/02/16 00:00 [revised]
PHST- 2017/04/12 06:00 [pubmed]
PHST- 2018/04/20 06:00 [medline]
PHST- 2017/04/12 06:00 [entrez]
AID - 10.1007/s11064-017-2252-6 [pii]
AID - 10.1007/s11064-017-2252-6 [doi]
PST - ppublish
SO  - Neurochem Res. 2017 Aug;42(8):2344-2353. doi: 10.1007/s11064-017-2252-6. Epub 
      2017 Apr 10.