PMID- 28397230
OWN - NLM
STAT- MEDLINE
DCOM- 20170914
LR  - 20221207
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 34
IP  - 2
DP  - 2017 Apr 10
TI  - [Identification of a novel HLA allele HLA-B*46:01:18].
PG  - 247-250
LID - 10.3760/cma.j.issn.1003-9406.2017.02.022 [doi]
AB  - OBJECTIVE: To report on a novel human leukocyte antigen (HLA) allele. METHODS: 
      Polymerase chain reaction-sequence based typing was used for routine HLA typing. 
      For one sample, the result of B locus typing showed mismatch of one base with 
      B*46:01:01, B*15:25:01 at locus 384. The group specific sequencing primers, which 
      target at B*46 and B*15, were used to confirm the difference between the novel 
      allele and the highest homologous allele. RESULTS: The sequencing results showed 
      that the highest homologous allele to the novel allele was B*46:01:01. The two 
      sequences only differed for position 384 within the exon 3 (384G>T), which 
      resulted in a codon change (GGG>GGT), though the amino acid sequence of the novel 
      allele at position 104 was still Glycine (G). Investigation of the family showed 
      that the novel allele was inherited from the father. CONCLUSION: The novel HLA-B 
      allele, discovered in ethnic Zhuangs from Guangxi, has been designated as HLA-B 
      *46:01:18 by the World Health Organization (WHO) HLA Nomenclature Committee.
FAU - Pei, Yongfeng
AU  - Pei Y
AD  - Nanning Institute of Transfusion Medicine, Nanning, Guangxi 530007, China. 
      shenweidong1960@sohu.com.
FAU - Huang, Huini
AU  - Huang H
FAU - Li, Hengcong
AU  - Li H
FAU - Shen, Weidong
AU  - Shen W
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Asian People/*genetics
MH  - Base Sequence
MH  - China
MH  - Exons
MH  - Female
MH  - HLA-B Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Molecular Sequence Data
MH  - Young Adult
EDAT- 2017/04/12 06:00
MHDA- 2017/09/15 06:00
CRDT- 2017/04/12 06:00
PHST- 2017/04/12 06:00 [entrez]
PHST- 2017/04/12 06:00 [pubmed]
PHST- 2017/09/15 06:00 [medline]
AID - 940634053 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2017.02.022 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017 Apr 10;34(2):247-250. doi: 
      10.3760/cma.j.issn.1003-9406.2017.02.022.