PMID- 28398495
OWN - NLM
STAT- MEDLINE
DCOM- 20171004
LR  - 20201209
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 102
IP  - 7
DP  - 2017 Jul 1
TI  - A Histological Study of Fulminant Type 1 Diabetes Mellitus Related to Human 
      Cytomegalovirus Reactivation.
PG  - 2394-2400
LID - 10.1210/jc.2016-4029 [doi]
AB  - CONTEXT: Fulminant type 1 diabetes mellitus (T1DM) is thought to be partly caused 
      by virus infection. OBJECTIVE: This study investigated the mechanism of beta cell 
      destruction in fulminant T1DM after drug-induced hypersensitivity syndrome 
      (DIHS). METHODS: We determined the localization of human cytomegalovirus (HCMV), 
      human herpesvirus 6 (HHV-6), and Epstein-Barr virus (EBV) and the expression of 
      interferon regulatory factor 3 (IRF3) and viral receptors of Z-DNA binding 
      protein 1 (ZBP1) and retinoic acid-inducible gene I (RIG-I), together with 
      inflammatory cells, by immunohistochemistry of the autopsy pancreas of a patient 
      with fulminant T1DM with DIHS and in seven subjects with normal glucose tolerance 
      who underwent pancreatectomy. RESULTS: HCMV-positive cells were detected in 
      islets and exocrine areas in the patient with fulminant T1DM. Greater numbers of 
      macrophages and CD4+ and CD8+ T lymphocytes had infiltrated into HCMV-positive 
      islets than into HCMV-negative islets, and 52.6% of HCMV-positive cells were also 
      positive for IRF3. alpha Cells expressed IRF3, ZBP1, or RIG-I. No HCMV-positive cells 
      were detected in the control subjects. HHV-6-positive, but not EBV-positive, 
      cells were present in the patient and the control subjects. CONCLUSIONS: These 
      findings indicate that the immunoresponse caused by HCMV infection was associated 
      with beta cell injury.
CI  - Copyright (c) 2017 Endocrine Society
FAU - Yoneda, Sho
AU  - Yoneda S
AD  - Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 
      Suita "565-0871", Japan.
FAU - Imagawa, Akihisa
AU  - Imagawa A
AD  - Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 
      Suita "565-0871", Japan.
AD  - Department of Internal Medicine (I), Osaka Medical College, Takatsuki "569-8686", 
      Japan.
FAU - Fukui, Kenji
AU  - Fukui K
AD  - Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 
      Suita "565-0871", Japan.
FAU - Uno, Sae
AU  - Uno S
AD  - Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 
      Suita "565-0871", Japan.
FAU - Kozawa, Junji
AU  - Kozawa J
AD  - Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 
      Suita "565-0871", Japan.
FAU - Sakai, Makoto
AU  - Sakai M
AD  - Internal Medicine, Konan Hospital, Kobe "658-0064", Japan.
FAU - Yumioka, Toshiki
AU  - Yumioka T
AD  - Internal Medicine, Konan Hospital, Kobe "658-0064", Japan.
FAU - Iwahashi, Hiromi
AU  - Iwahashi H
AD  - Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 
      Suita "565-0871", Japan.
FAU - Shimomura, Iichiro
AU  - Shimomura I
AD  - Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 
      Suita "565-0871", Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Interferon Regulatory Factor-3)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (ZBP1 protein, human)
SB  - IM
MH  - Aged
MH  - Biopsy, Needle
MH  - Case-Control Studies
MH  - Cells, Cultured
MH  - Cytomegalovirus/*pathogenicity
MH  - Cytomegalovirus Infections/*physiopathology
MH  - DNA-Binding Proteins/metabolism
MH  - Diabetes Mellitus, Type 1/*pathology/physiopathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Insulin-Secreting Cells/*metabolism/virology
MH  - Interferon Regulatory Factor-3/*metabolism
MH  - Male
MH  - RNA-Binding Proteins
MH  - Reference Values
MH  - Severity of Illness Index
MH  - Statistics, Nonparametric
MH  - *Virus Activation
EDAT- 2017/04/12 06:00
MHDA- 2017/10/05 06:00
CRDT- 2017/04/12 06:00
PHST- 2016/12/26 00:00 [received]
PHST- 2017/04/05 00:00 [accepted]
PHST- 2017/04/12 06:00 [pubmed]
PHST- 2017/10/05 06:00 [medline]
PHST- 2017/04/12 06:00 [entrez]
AID - 3111245 [pii]
AID - 10.1210/jc.2016-4029 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2017 Jul 1;102(7):2394-2400. doi: 10.1210/jc.2016-4029.