PMID- 2839962
OWN - NLM
STAT- MEDLINE
DCOM- 19880819
LR  - 20190824
IS  - 0065-4299 (Print)
IS  - 0065-4299 (Linking)
VI  - 23
IP  - 3-4
DP  - 1988 Apr
TI  - Antihistaminic activity of stobadine in the peripheral and central nervous 
      system.
PG  - 257-9
AB  - Stobadine in low doses induced hyperpolarization, and in high doses 
      depolarization and inhibition of transmission in the cat superior cervical 
      ganglion. The ganglionic depolarizing action of histamine was inhibited by 
      stobadine in low doses. Stobadine partially depressed ganglionic responses to 
      isoprenaline, serotonin, M1 muscarinic agonist McN-A-343 and clonidine only in 
      high doses. Stobadine administered into the third cerebral ventricle of 
      anaesthetized cats evoked dose-dependent hypotension without changes in heart 
      rate. Intracerebroventricular (i.c.v.) administration of histamine evoked 
      hypertension followed by hypotension. Both effects were inhibited by i.c.v. 
      pretreatment with stobadine. These results indicate that in nervous tissue 
      stobadine antagonises histamine responses presumably due to H1-receptor 
      stimulation.
FAU - Lukovic, L
AU  - Lukovic L
AD  - Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, 
      Czechoslovakia.
FAU - Machova, J
AU  - Machova J
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Agents Actions
JT  - Agents and actions
JID - 0213341
RN  - 0 (Carbolines)
RN  - 0 (Histamine Antagonists)
RN  - Y0EA50IJ3V (dicarbine)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Carbolines/*pharmacology
MH  - Cats
MH  - Female
MH  - *Histamine Antagonists
MH  - Male
MH  - Membrane Potentials/drug effects
MH  - Nervous System/*drug effects
MH  - Nervous System Physiological Phenomena
MH  - Synaptic Transmission/drug effects
EDAT- 1988/04/01 00:00
MHDA- 1988/04/01 00:01
CRDT- 1988/04/01 00:00
PHST- 1988/04/01 00:00 [pubmed]
PHST- 1988/04/01 00:01 [medline]
PHST- 1988/04/01 00:00 [entrez]
AID - 10.1007/BF02142557 [doi]
PST - ppublish
SO  - Agents Actions. 1988 Apr;23(3-4):257-9. doi: 10.1007/BF02142557.