PMID- 28399791 OWN - NLM STAT- MEDLINE DCOM- 20190115 LR - 20190115 IS - 1476-8305 (Electronic) IS - 1028-415X (Linking) VI - 21 IP - 7 DP - 2018 Sep TI - Highly palatable food access during adolescence increased anxiety-/depression-like behaviors in male, but not in female, rats. PG - 502-510 LID - 10.1080/1028415X.2017.1313583 [doi] AB - OBJECTIVES: This study was conducted to examine the sexual dimorphic effects of highly palatable food (HPF) access during adolescence on the neurochemistry and depression-/anxiety-like behaviors of rats. METHODS: Male and female Sprague-Dawley pups had free access to chocolate cookie rich in fat (HPF) from postnatal day 28 in addition to ad libitum chow, and the control groups received only chow. The food conditions were continued throughout the entire experimental period, and the neurochemical and behavioral measurements were performed during young adulthood. Rats were subjected to the ambulatory activity, elevated plus maze, and forced swim tests. Corticosterone levels during 2 h of restraint stress were analyzed with radioimmunoassay, and DeltaFosB and brain-derived neurotrophic factor (BDNF) expression in the nucleus accumbens (NAc) with Western blot analysis. RESULTS: Cookie access did not affect body weight gain and total caloric intake in both sexes; however, it increased retroperitoneal fat depot only in males. The time spent in open arms during elevated plus maze test was decreased and immobility during forced swim test was increased in cookie-fed males, but not in cookie-fed females. Main effect of food condition on the stress-induced corticosterone increase was observed in males, but not in females, and cookie access increased BDNF expression in the NAc only in males. CONCLUSIONS: Increased BDNF expression in the NAc and fat depot, in addition to the stress axis dysfunction, may play roles in the pathophysiology of depression- and/or anxiety-like behaviors induced by cookie access. FAU - Kim, Jin Young AU - Kim JY AD - a Department of Oral and Maxillofacial Surgery , Dental Research Institute, Seoul National University School of Dentistry , Seoul 110-768 , Korea. FAU - Kim, Doyun AU - Kim D AD - a Department of Oral and Maxillofacial Surgery , Dental Research Institute, Seoul National University School of Dentistry , Seoul 110-768 , Korea. AD - b Department of Brain Science , Daegu Gyeongbuk Institute of Science & Technology , Dae Gu 711-873 , Korea. FAU - Park, Kyungpyo AU - Park K AD - c Department of Physiology , Dental Research Institute, Seoul National University School of Dentistry , Seoul 110-768 , Korea. FAU - Lee, Jong-Ho AU - Lee JH AD - a Department of Oral and Maxillofacial Surgery , Dental Research Institute, Seoul National University School of Dentistry , Seoul 110-768 , Korea. FAU - Jahng, Jeong Won AU - Jahng JW AD - a Department of Oral and Maxillofacial Surgery , Dental Research Institute, Seoul National University School of Dentistry , Seoul 110-768 , Korea. LA - eng PT - Journal Article DEP - 20170411 PL - England TA - Nutr Neurosci JT - Nutritional neuroscience JID - 100892202 RN - 0 (Bdnf protein, rat) RN - 0 (Brain-Derived Neurotrophic Factor) RN - W980KJ009P (Corticosterone) SB - IM MH - Animals MH - Anxiety/*blood/etiology MH - Behavior, Animal MH - Brain-Derived Neurotrophic Factor/genetics/metabolism MH - Corticosterone/blood MH - Depression/*blood/etiology MH - *Diet MH - Disease Models, Animal MH - Female MH - Male MH - Maze Learning MH - Nucleus Accumbens/metabolism MH - Physical Conditioning, Animal MH - Rats MH - Rats, Sprague-Dawley MH - *Sex Factors MH - Stress, Psychological/blood/complications MH - Weight Gain OTO - NOTNLM OT - Corticosterone OT - Food intake OT - Nucleus accumbens OT - Stress EDAT- 2017/04/13 06:00 MHDA- 2019/01/16 06:00 CRDT- 2017/04/13 06:00 PHST- 2017/04/13 06:00 [pubmed] PHST- 2019/01/16 06:00 [medline] PHST- 2017/04/13 06:00 [entrez] AID - 10.1080/1028415X.2017.1313583 [doi] PST - ppublish SO - Nutr Neurosci. 2018 Sep;21(7):502-510. doi: 10.1080/1028415X.2017.1313583. Epub 2017 Apr 11.