PMID- 28400914
OWN - NLM
STAT- MEDLINE
DCOM- 20170504
LR  - 20220408
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2017
DP  - 2017
TI  - Physical Exercise on Inflammatory Markers in Type 2 Diabetes Patients: A 
      Systematic Review of Randomized Controlled Trials.
PG  - 8523728
LID - 10.1155/2017/8523728 [doi]
LID - 8523728
AB  - Background. Type 2 diabetes mellitus (T2DM) is a serious disease associated with 
      high morbidity and mortality. Scientific findings showed that physical exercise 
      is an option for treatment of these patients. This study's objective is to 
      investigate the effects of supervised aerobic and/or resistance physical training 
      on inflammatory markers in subjects with T2DM. Methods. A systematic review was 
      conducted on four databases, MEDLINE, CENTRAL, LILACS, and Scopus, and manual 
      search from 21 to 30 November 2016. Randomized clinical trials involving 
      individuals diagnosed with T2DM, who have undergone supervised training 
      protocols, were selected in this study. Results. Eleven studies were included. 
      Studies that evaluated control group versus aerobic exercise reported 
      controversial results about the effectiveness of physical training in modifying 
      C-reactive protein (CRP) and cytokine levels. The only variable analyzed by the 
      six studies in comparison to the control group versus resistance exercise was 
      CRP. This protein showed no significant difference between groups. Between the 
      two modes of exercise (aerobic and resistance), only one study demonstrated that 
      aerobic exercise was more effective in reducing CRP. Conclusion. The evidence was 
      insufficient to prove that aerobic or resistance exercise improves systemic 
      levels of inflammatory markers in patients with T2DM.
FAU - Melo, Luciana Costa
AU  - Melo LC
AD  - Programa de Pos-Graduacao em Ciencias da Saude, Instituto de Ciencias Biologicas 
      e da Saude, Universidade Federal de Alagoas, Campus A. C. Simoes, Av. Lourival 
      Melo Mota, s/n, Tabuleiro do Martins, 57072-900 Maceio, AL, Brazil; Laboratorio 
      de Reatividade Cardiovascular, Setor de Fisiologia, Nucleo de Sindrome 
      Metabolica, Instituto de Ciencias Biologicas e da Saude, Universidade Federal de 
      Alagoas, Maceio, AL, Brazil; Instituto Nacional de Ciencia e Tecnologia em 
      Nanobiofarmaceutica (N-BIOFAR), Belo Horizonte, MG, Brazil.
FAU - Dativo-Medeiros, Jaime
AU  - Dativo-Medeiros J
AD  - Programa de Pos-Graduacao em Ciencias da Saude, Instituto de Ciencias Biologicas 
      e da Saude, Universidade Federal de Alagoas, Campus A. C. Simoes, Av. Lourival 
      Melo Mota, s/n, Tabuleiro do Martins, 57072-900 Maceio, AL, Brazil; Laboratorio 
      de Reatividade Cardiovascular, Setor de Fisiologia, Nucleo de Sindrome 
      Metabolica, Instituto de Ciencias Biologicas e da Saude, Universidade Federal de 
      Alagoas, Maceio, AL, Brazil; Instituto Nacional de Ciencia e Tecnologia em 
      Nanobiofarmaceutica (N-BIOFAR), Belo Horizonte, MG, Brazil.
FAU - Menezes-Silva, Carlos Eduardo
AU  - Menezes-Silva CE
AD  - Programa de Pos-Graduacao em Ciencias da Saude, Instituto de Ciencias Biologicas 
      e da Saude, Universidade Federal de Alagoas, Campus A. C. Simoes, Av. Lourival 
      Melo Mota, s/n, Tabuleiro do Martins, 57072-900 Maceio, AL, Brazil; Laboratorio 
      de Reatividade Cardiovascular, Setor de Fisiologia, Nucleo de Sindrome 
      Metabolica, Instituto de Ciencias Biologicas e da Saude, Universidade Federal de 
      Alagoas, Maceio, AL, Brazil; Instituto Nacional de Ciencia e Tecnologia em 
      Nanobiofarmaceutica (N-BIOFAR), Belo Horizonte, MG, Brazil.
FAU - Barbosa, Fabiano Timbo
AU  - Barbosa FT
AUID- ORCID: 0000-0001-6630-0629
AD  - Programa de Pos-Graduacao em Ciencias da Saude, Instituto de Ciencias Biologicas 
      e da Saude, Universidade Federal de Alagoas, Campus A. C. Simoes, Av. Lourival 
      Melo Mota, s/n, Tabuleiro do Martins, 57072-900 Maceio, AL, Brazil.
FAU - de Sousa-Rodrigues, Celio Fernando
AU  - de Sousa-Rodrigues CF
AD  - Programa de Pos-Graduacao em Ciencias da Saude, Instituto de Ciencias Biologicas 
      e da Saude, Universidade Federal de Alagoas, Campus A. C. Simoes, Av. Lourival 
      Melo Mota, s/n, Tabuleiro do Martins, 57072-900 Maceio, AL, Brazil.
FAU - Rabelo, Luiza A
AU  - Rabelo LA
AUID- ORCID: 0000-0001-9280-6527
AD  - Programa de Pos-Graduacao em Ciencias da Saude, Instituto de Ciencias Biologicas 
      e da Saude, Universidade Federal de Alagoas, Campus A. C. Simoes, Av. Lourival 
      Melo Mota, s/n, Tabuleiro do Martins, 57072-900 Maceio, AL, Brazil; Laboratorio 
      de Reatividade Cardiovascular, Setor de Fisiologia, Nucleo de Sindrome 
      Metabolica, Instituto de Ciencias Biologicas e da Saude, Universidade Federal de 
      Alagoas, Maceio, AL, Brazil; Instituto Nacional de Ciencia e Tecnologia em 
      Nanobiofarmaceutica (N-BIOFAR), Belo Horizonte, MG, Brazil; Max Delbruck Center 
      for Molecular Medicine, Berlin, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20170319
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Biomarkers/analysis
MH  - C-Reactive Protein/analysis
MH  - Databases, Factual
MH  - Diabetes Mellitus, Type 2/metabolism/*pathology
MH  - *Exercise
MH  - Humans
MH  - Randomized Controlled Trials as Topic
PMC - PMC5376457
EDAT- 2017/04/13 06:00
MHDA- 2017/05/05 06:00
PMCR- 2017/03/19
CRDT- 2017/04/13 06:00
PHST- 2016/10/15 00:00 [received]
PHST- 2016/12/07 00:00 [revised]
PHST- 2017/02/23 00:00 [accepted]
PHST- 2017/04/13 06:00 [entrez]
PHST- 2017/04/13 06:00 [pubmed]
PHST- 2017/05/05 06:00 [medline]
PHST- 2017/03/19 00:00 [pmc-release]
AID - 10.1155/2017/8523728 [doi]
PST - ppublish
SO  - Oxid Med Cell Longev. 2017;2017:8523728. doi: 10.1155/2017/8523728. Epub 2017 Mar 
      19.